ENSG00000277632


Homo sapiens

Features
Gene ID: ENSG00000277632
  
Biological name :CCL3
  
Synonyms : CCL3 / C-C motif chemokine ligand 3 / P10147
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q12
Gene start: 36088256
Gene end: 36090169
  
Corresponding Affymetrix probe sets: 205114_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000477908
NCBI entrez gene - 6348     See in Manteia.
OMIM - 182283
RefSeq - NM_002983
RefSeq Peptide - NP_002974
swissprot - A0N0R1
swissprot - P10147
Ensembl - ENSG00000277632
  
Related genetic diseases (OMIM): 609423 - {HIV infection, resistance to}, 609423
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccl35.1ENSDARG00000103466Danio rerio
 ccl35.2ENSDARG00000070378Danio rerio
 ENSGALG00000041079Gallus gallus
 ENSGALG00000043065Gallus gallus
 ENSGALG00000014585Gallus gallus
 CCAH221ENSGALG00000027051Gallus gallus
 CCL4ENSGALG00000034478Gallus gallus
 CCL4ENSGALG00000032717Gallus gallus
 Ccl3ENSMUSG00000000982Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCL3L1 / CCL3L3 / P16619 / C-C motif chemokine ligand 3 like 1ENSG0000027608596
CCL18 / P55774 / C-C motif chemokine ligand 18ENSG0000027538561
CCL4 / P13236 / C-C motif chemokine ligand 4ENSG0000027530258
CCL5 / P13501 / C-C motif chemokine ligand 5ENSG0000027150348
CCL14 / Q16627 / C-C motif chemokine ligand 14ENSG0000027640947
CCL26 / Q9Y258 / C-C motif chemokine ligand 26ENSG0000000660637
CCL16 / O15467 / C-C motif chemokine ligand 16ENSG0000027515236
CCL4L2 / Q8NHW4 / C-C motif chemokine ligand 4 like 2ENSG0000027607036


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0001649 osteoblast differentiation IEP
 biological_processGO:0001775 cell activation IDA
 biological_processGO:0002548 monocyte chemotaxis IDA
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0006887 exocytosis IDA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007010 cytoskeleton organization IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IDA
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0009636 response to toxic substance IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010629 negative regulation of gene expression IDA
 biological_processGO:0010818 T cell chemotaxis IDA
 biological_processGO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019722 calcium-mediated signaling IDA
 biological_processGO:0023052 signaling IEP
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0030502 negative regulation of bone mineralization IDA
 biological_processGO:0030593 neutrophil chemotaxis IDA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISS
 biological_processGO:0043308 eosinophil degranulation IDA
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process ISS
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0043615 astrocyte cell migration ISS
 biological_processGO:0043922 negative regulation by host of viral transcription IDA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IDA
 biological_processGO:0048245 eosinophil chemotaxis IDA
 biological_processGO:0048246 macrophage chemotaxis ISS
 biological_processGO:0048247 lymphocyte chemotaxis IDA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion ISS
 biological_processGO:0050729 positive regulation of inflammatory response ISS
 biological_processGO:0050795 regulation of behavior IDA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IMP
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEP
 biological_processGO:0051928 positive regulation of calcium ion transport IDA
 biological_processGO:0051930 regulation of sensory perception of pain IDA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070723 response to cholesterol IDA
 biological_processGO:0071346 cellular response to interferon-gamma IEP
 biological_processGO:0071347 cellular response to interleukin-1 IEP
 biological_processGO:0071356 cellular response to tumor necrosis factor IEP
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0071621 granulocyte chemotaxis IDA
 biological_processGO:0090280 positive regulation of calcium ion import TAS
 biological_processGO:2000503 positive regulation of natural killer cell chemotaxis IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004698 calcium-dependent protein kinase C activity IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity IDA
 molecular_functionGO:0016004 phospholipase activator activity IDA
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0031726 CCR1 chemokine receptor binding IPI
 molecular_functionGO:0031730 CCR5 chemokine receptor binding IPI
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-10 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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