ENSG00000275302


Homo sapiens

Features
Gene ID: ENSG00000275302
  
Biological name :CCL4
  
Synonyms : CCL4 / C-C motif chemokine ligand 4 / P13236
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q12
Gene start: 36103590
Gene end: 36105621
  
Corresponding Affymetrix probe sets: 204103_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480569
Ensembl peptide - ENSP00000482259
NCBI entrez gene - 6351     See in Manteia.
OMIM - 182284
RefSeq - NM_002984
RefSeq Peptide - NP_002975
swissprot - P13236
swissprot - Q7M4M2
Ensembl - ENSG00000275302
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccl35.1ENSDARG00000103466Danio rerio
 ccl35.2ENSDARG00000070378Danio rerio
 ENSGALG00000041079Gallus gallus
 ENSGALG00000043065Gallus gallus
 ENSGALG00000014585Gallus gallus
 CCAH221ENSGALG00000027051Gallus gallus
 CCL4ENSGALG00000034478Gallus gallus
 CCL4ENSGALG00000032717Gallus gallus
 Ccl4ENSMUSG00000018930Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCL4L2 / Q8NHW4 / C-C motif chemokine ligand 4 like 2ENSG0000027607068
CCL3L1 / CCL3L3 / P16619 / C-C motif chemokine ligand 3 like 1ENSG0000027608559
CCL3 / P10147 / C-C motif chemokine ligand 3ENSG0000027763258
CCL5 / P13501 / C-C motif chemokine ligand 5ENSG0000027150346
CCL14 / Q16627 / C-C motif chemokine ligand 14ENSG0000027640943
CCL18 / P55774 / C-C motif chemokine ligand 18ENSG0000027538542
CCL16 / O15467 / C-C motif chemokine ligand 16ENSG0000027515237
CCL26 / Q9Y258 / C-C motif chemokine ligand 26ENSG0000000660636


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007163 establishment or maintenance of cell polarity TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0009615 response to virus TAS
 biological_processGO:0009636 response to toxic substance IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0043922 negative regulation by host of viral transcription IDA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IMP
 biological_processGO:0051928 positive regulation of calcium ion transport IDA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 biological_processGO:2000503 positive regulation of natural killer cell chemotaxis IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 molecular_functionGO:0005125 cytokine activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity TAS
 molecular_functionGO:0031726 CCR1 chemokine receptor binding IPI
 molecular_functionGO:0031730 CCR5 chemokine receptor binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Interleukin-10 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000160791 CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)  / complex
 ENSG00000163823 CCR1 / P32246 / C-C motif chemokine receptor 1  / complex






 

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