ENSG00000271503


Homo sapiens

Features
Gene ID: ENSG00000271503
  
Biological name :CCL5
  
Synonyms : CCL5 / C-C motif chemokine ligand 5 / P13501
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q12
Gene start: 35871491
Gene end: 35880793
  
Corresponding Affymetrix probe sets: 1405_i_at (Human Genome U133 Plus 2.0 Array)   1555759_a_at (Human Genome U133 Plus 2.0 Array)   204655_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000474141
Ensembl peptide - ENSP00000475057
Ensembl peptide - ENSP00000474412
NCBI entrez gene - 6352     See in Manteia.
OMIM - 187011
RefSeq - NM_002985
RefSeq - NM_001278736
RefSeq Peptide - NP_001265665
RefSeq Peptide - NP_002976
swissprot - P13501
swissprot - D0EI67
swissprot - A0A075B7C5
Ensembl - ENSG00000271503
  
Related genetic diseases (OMIM): 187011 - {HIV-1 disease, delayed progression of}
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccl35.1ENSDARG00000103466Danio rerio
 ccl35.2ENSDARG00000070378Danio rerio
 CCL5ENSGALG00000043603Gallus gallus
 Ccl5ENSMUSG00000035042Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCL3L1 / CCL3L3 / P16619 / C-C motif chemokine ligand 3 like 1ENSG0000027608549
CCL3 / P10147 / C-C motif chemokine ligand 3ENSG0000027763248
CCL4 / P13236 / C-C motif chemokine ligand 4ENSG0000027530246
CCL16 / O15467 / C-C motif chemokine ligand 16ENSG0000027515242
CCL26 / Q9Y258 / C-C motif chemokine ligand 26ENSG0000000660640
CCL14 / Q16627 / C-C motif chemokine ligand 14ENSG0000027640938
CCL18 / P55774 / C-C motif chemokine ligand 18ENSG0000027538537
CCL4L2 / Q8NHW4 / C-C motif chemokine ligand 4 like 2ENSG0000027607032


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR030595  C-C motif chemokine 5
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0002407 dendritic cell chemotaxis TAS
 biological_processGO:0002548 monocyte chemotaxis IC
 biological_processGO:0002676 regulation of chronic inflammatory response TAS
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0006887 exocytosis IDA
 biological_processGO:0006935 chemotaxis NAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling IDA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0009636 response to toxic substance IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010536 positive regulation of activation of Janus kinase activity TAS
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IDA
 biological_processGO:0010820 positive regulation of T cell chemotaxis IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0031328 positive regulation of cellular biosynthetic process IDA
 biological_processGO:0031584 activation of phospholipase D activity IDA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0033634 positive regulation of cell-cell adhesion mediated by integrin IDA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0034112 positive regulation of homotypic cell-cell adhesion IDA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0042119 neutrophil activation IDA
 biological_processGO:0042327 positive regulation of phosphorylation IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0043922 negative regulation by host of viral transcription IDA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEP
 biological_processGO:0045070 positive regulation of viral genome replication TAS
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045089 positive regulation of innate immune response TAS
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IDA
 biological_processGO:0045785 positive regulation of cell adhesion IDA
 biological_processGO:0045948 positive regulation of translational initiation NAS
 biological_processGO:0046427 positive regulation of JAK-STAT cascade TAS
 biological_processGO:0048245 eosinophil chemotaxis IDA
 biological_processGO:0048246 macrophage chemotaxis TAS
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IDA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050796 regulation of insulin secretion IDA
 biological_processGO:0050863 regulation of T cell activation IDA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051262 protein tetramerization IDA
 biological_processGO:0051928 positive regulation of calcium ion transport IDA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0070100 negative regulation of chemokine-mediated signaling pathway IEA
 biological_processGO:0070233 negative regulation of T cell apoptotic process IDA
 biological_processGO:0070234 positive regulation of T cell apoptotic process IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IEP
 biological_processGO:0071347 cellular response to interleukin-1 IEP
 biological_processGO:0071356 cellular response to tumor necrosis factor IEP
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IDA
 biological_processGO:1901214 regulation of neuron death IDA
 biological_processGO:2000110 negative regulation of macrophage apoptotic process IEA
 biological_processGO:2000406 positive regulation of T cell migration IDA
 biological_processGO:2000503 positive regulation of natural killer cell chemotaxis IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IDA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity IEA
 molecular_functionGO:0016004 phospholipase activator activity IDA
 molecular_functionGO:0030298 receptor signaling protein tyrosine kinase activator activity IDA
 molecular_functionGO:0031726 CCR1 chemokine receptor binding IEA
 molecular_functionGO:0031729 CCR4 chemokine receptor binding IEA
 molecular_functionGO:0031730 CCR5 chemokine receptor binding IEA
 molecular_functionGO:0042056 chemoattractant activity IDA
 molecular_functionGO:0042379 chemokine receptor binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0043621 protein self-association IDA
 molecular_functionGO:0046817 chemokine receptor antagonist activity IDA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000160791 CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)  / complex / reaction
 ENSG00000183813 CCR4 / P51679 / C-C motif chemokine receptor 4  / reaction / complex
 ENSG00000183625 CCR3 / P51677 / C-C motif chemokine receptor 3  / reaction / complex






 

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