ENSG00000183813


Homo sapiens

Features
Gene ID: ENSG00000183813
  
Biological name :CCR4
  
Synonyms : C-C motif chemokine receptor 4 / CCR4 / P51679
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p22.3
Gene start: 32951574
Gene end: 32956349
  
Corresponding Affymetrix probe sets: 208376_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000332659
NCBI entrez gene - 1233     See in Manteia.
OMIM - 604836
RefSeq - XM_017005687
RefSeq - NM_005508
RefSeq Peptide - NP_005499
swissprot - P51679
swissprot - A0N0Q1
Ensembl - ENSG00000183813
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccr11.1ENSDARG00000070755Danio rerio
 ccr2ENSDARG00000105363Danio rerio
 ccr2ENSDARG00000079829Danio rerio
 CCR4ENSGALG00000039146Gallus gallus
 Ccr4ENSMUSG00000047898Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)ENSG0000016079146
CCR1 / P32246 / C-C motif chemokine receptor 1ENSG0000016382346
CCR2 / P41597 / C-C motif chemokine receptor 2ENSG0000012180744
CCR3 / P51677 / C-C motif chemokine receptor 3ENSG0000018362543
CCR8 / P51685 / C-C motif chemokine receptor 8ENSG0000017993443
CX3CR1 / P49238 / C-X3-C motif chemokine receptor 1ENSG0000016832939
ACKR2 / O00590 / atypical chemokine receptor 2ENSG0000014464838
CXCR2 / P25025 / C-X-C motif chemokine receptor 2ENSG0000018087135
CCR6 / P51684 / C-C motif chemokine receptor 6ENSG0000011248634
CCR7 / P32248 / C-C motif chemokine receptor 7ENSG0000012635334
CXCR1 / P25024 / C-X-C motif chemokine receptor 1ENSG0000016346434
CCR9 / P51686 / C-C motif chemokine receptor 9ENSG0000017358533
CXCR4 / P61073 / C-X-C motif chemokine receptor 4ENSG0000012196633
CXCR3 / P49682 / C-X-C motif chemokine receptor 3ENSG0000018681031
XCR1 / P46094 / X-C motif chemokine receptor 1ENSG0000017357831
ACKR4 / Q9NPB9 / atypical chemokine receptor 4ENSG0000012904830
CXCR5 / P32302 / C-X-C motif chemokine receptor 5ENSG0000016068329
CCR10 / P46092 / C-C motif chemokine receptor 10ENSG0000018445128
CXCR6 / O00574 / C-X-C motif chemokine receptor 6ENSG0000017221527


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR002239  CC chemokine receptor 4
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0002507 tolerance induction IEA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration TAS
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0048872 homeostasis of number of cells IEA
 biological_processGO:0050927 positive regulation of positive chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity TAS
 molecular_functionGO:0016493 C-C chemokine receptor activity IEA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000271503 CCL5 / P13501 / C-C motif chemokine ligand 5  / complex / reaction






 

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