ENSG00000163464


Homo sapiens

Features
Gene ID: ENSG00000163464
  
Biological name :CXCR1
  
Synonyms : C-X-C motif chemokine receptor 1 / CXCR1 / P25024
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q35
Gene start: 218162845
Gene end: 218166995
  
Corresponding Affymetrix probe sets: 207094_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295683
NCBI entrez gene - 3577     See in Manteia.
OMIM - 146929
RefSeq - NM_000634
RefSeq Peptide - NP_000625
swissprot - P25024
Ensembl - ENSG00000163464
  
Related genetic diseases (OMIM): 609423 - {AIDS, slow progression to}, 609423
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcr2ENSDARG00000054975Danio rerio
 CXCR1ENSGALG00000036627Gallus gallus
 Cxcr1ENSMUSG00000048480Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CXCR2 / P25025 / C-X-C motif chemokine receptor 2ENSG0000018087177
CCR6 / P51684 / C-C motif chemokine receptor 6ENSG0000011248639
CXCR3 / P49682 / C-X-C motif chemokine receptor 3ENSG0000018681037
CXCR4 / P61073 / C-X-C motif chemokine receptor 4ENSG0000012196635
CCR4 / P51679 / C-C motif chemokine receptor 4ENSG0000018381335
CCR9 / P51686 / C-C motif chemokine receptor 9ENSG0000017358534
CXCR5 / P32302 / C-X-C motif chemokine receptor 5ENSG0000016068334
CCR7 / P32248 / C-C motif chemokine receptor 7ENSG0000012635333
CCR8 / P51685 / C-C motif chemokine receptor 8ENSG0000017993432
CCR10 / P46092 / C-C motif chemokine receptor 10ENSG0000018445132
ACKR2 / O00590 / atypical chemokine receptor 2ENSG0000014464831
CCR2 / P41597 / C-C motif chemokine receptor 2ENSG0000012180730
CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)ENSG0000016079130
ACKR4 / Q9NPB9 / atypical chemokine receptor 4ENSG0000012904829
CCR3 / P51677 / C-C motif chemokine receptor 3ENSG0000018362529
XCR1 / P46094 / X-C motif chemokine receptor 1ENSG0000017357829
CX3CR1 / P49238 / C-X3-C motif chemokine receptor 1ENSG0000016832929
CCR1 / P32246 / C-C motif chemokine receptor 1ENSG0000016382329
CXCR6 / O00574 / C-X-C motif chemokine receptor 6ENSG0000017221528


Protein motifs (from Interpro)
Interpro ID Name
 IPR000174  CXC chemokine receptor 1/2
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001355  CXC chemokine receptor 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002407 dendritic cell chemotaxis TAS
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0038112 interleukin-8-mediated signaling pathway IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004918 interleukin-8 receptor activity IDA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0004950 chemokine receptor activity TAS
 molecular_functionGO:0016494 C-X-C chemokine receptor activity IEA
 molecular_functionGO:0019959 interleukin-8 binding IPI


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169429 CXCL8 / P10145 / C-X-C motif chemokine ligand 8  / reaction / complex
 ENSG00000124875 CXCL6 / P80162 / C-X-C motif chemokine ligand 6  / reaction / complex






 

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