ENSG00000124875


Homo sapiens

Features
Gene ID: ENSG00000124875
  
Biological name :CXCL6
  
Synonyms : CXCL6 / C-X-C motif chemokine ligand 6 / P80162
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q13.3
Gene start: 73836497
Gene end: 73849064
  
Corresponding Affymetrix probe sets: 206336_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000226317
Ensembl peptide - ENSP00000424819
NCBI entrez gene - 6372     See in Manteia.
OMIM - 138965
RefSeq - NM_002993
RefSeq Peptide - NP_002984
swissprot - D6RF92
swissprot - P80162
Ensembl - ENSG00000124875
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcl19ENSDARG00000102776Danio rerio
 ENSGALG00000046160Gallus gallus
 Cxcl5ENSMUSG00000029371Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CXCL5 / P42830 / C-X-C motif chemokine ligand 5ENSG0000016373580
PPBP / P02775 / pro-platelet basic proteinENSG0000016373639
CXCL1 / P09341 / C-X-C motif chemokine ligand 1ENSG0000016373938
CXCL3 / P19876 / C-X-C motif chemokine ligand 3ENSG0000016373437
CXCL2 / P19875 / C-X-C motif chemokine ligand 2ENSG0000008104136
CXCL8 / P10145 / C-X-C motif chemokine ligand 8ENSG0000016942925


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR018048  CXC chemokine, conserved site
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002446 neutrophil mediated immunity IBA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030593 neutrophil chemotaxis IDA
 biological_processGO:0042119 neutrophil activation IDA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0045236 CXCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163464 CXCR1 / P25024 / C-X-C motif chemokine receptor 1  / reaction / complex






 

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