ENSG00000169429


Homo sapiens

Features
Gene ID: ENSG00000169429
  
Biological name :CXCL8
  
Synonyms : CXCL8 / C-X-C motif chemokine ligand 8 / P10145
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q13.3
Gene start: 73740506
Gene end: 73743716
  
Corresponding Affymetrix probe sets: 202859_x_at (Human Genome U133 Plus 2.0 Array)   211506_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000306512
Ensembl peptide - ENSP00000385908
NCBI entrez gene - 3576     See in Manteia.
OMIM - 146930
RefSeq - NM_000584
RefSeq Peptide - NP_000575
swissprot - C9J4T6
swissprot - A0A024RDA5
swissprot - P10145
Ensembl - ENSG00000169429
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcl8aENSDARG00000104795Danio rerio
 IL8ENSGALG00000026098Gallus gallus
 IL8L1ENSGALG00000011668Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PPBP / P02775 / pro-platelet basic proteinENSG0000016373640
CXCL2 / P19875 / C-X-C motif chemokine ligand 2ENSG0000008104139
CXCL1 / P09341 / C-X-C motif chemokine ligand 1ENSG0000016373939
CXCL3 / P19876 / C-X-C motif chemokine ligand 3ENSG0000016373437
CXCL5 / P42830 / C-X-C motif chemokine ligand 5ENSG0000016373531
CXCL6 / P80162 / C-X-C motif chemokine ligand 6ENSG0000012487528


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR018048  CXC chemokine, conserved site
 IPR028469  Interleukin-8
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis TAS
 biological_processGO:0002237 response to molecule of bacterial origin IDA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007050 cell cycle arrest IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019722 calcium-mediated signaling TAS
 biological_processGO:0030155 regulation of cell adhesion IDA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0036499 PERK-mediated unfolded protein response TAS
 biological_processGO:0042119 neutrophil activation IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEP
 biological_processGO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IDA
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0048566 embryonic digestive tract development IEP
 biological_processGO:0050930 induction of positive chemotaxis IGI
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071347 cellular response to interleukin-1 IEP
 biological_processGO:0071356 cellular response to tumor necrosis factor IEP
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis TAS
 biological_processGO:2000535 regulation of entry of bacterium into host cell IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005153 interleukin-8 receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity IEA


Pathways (from Reactome)
Pathway description
Senescence-Associated Secretory Phenotype (SASP)
Peptide ligand-binding receptors
Chemokine receptors bind chemokines
ATF4 activates genes
G alpha (i) signalling events
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163464 CXCR1 / P25024 / C-X-C motif chemokine receptor 1  / reaction / complex
 ENSG00000213088 ACKR1 / Q16570 / atypical chemokine receptor 1 (Duffy blood group)  / complex / reaction






 

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