ENSG00000163739


Homo sapiens

Features
Gene ID: ENSG00000163739
  
Biological name :CXCL1
  
Synonyms : CXCL1 / C-X-C motif chemokine ligand 1 / P09341
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q13.3
Gene start: 73869393
Gene end: 73871242
  
Corresponding Affymetrix probe sets: 204470_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379110
NCBI entrez gene - 2919     See in Manteia.
OMIM - 155730
RefSeq - NM_001511
RefSeq Peptide - NP_001502
swissprot - P09341
Ensembl - ENSG00000163739
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcl19ENSDARG00000102776Danio rerio
 ENSGALG00000046160Gallus gallus
 Cxcl1ENSMUSG00000029380Mus musculus
 Cxcl2ENSMUSG00000058427Mus musculus
 Cxcl3ENSMUSG00000029379Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CXCL2 / P19875 / C-X-C motif chemokine ligand 2ENSG0000008104190
CXCL3 / P19876 / C-X-C motif chemokine ligand 3ENSG0000016373487
PPBP / P02775 / pro-platelet basic proteinENSG0000016373649
CXCL5 / P42830 / C-X-C motif chemokine ligand 5ENSG0000016373544
CXCL6 / P80162 / C-X-C motif chemokine ligand 6ENSG0000012487540
CXCL8 / P10145 / C-X-C motif chemokine ligand 8ENSG0000016942936


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR018048  CXC chemokine, conserved site
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030036 actin cytoskeleton organization TAS
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:1904724 tertiary granule lumen TAS
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity TAS
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0045236 CXCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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