ENSG00000081041


Homo sapiens

Features
Gene ID: ENSG00000081041
  
Biological name :CXCL2
  
Synonyms : CXCL2 / C-X-C motif chemokine ligand 2 / P19875
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q13.3
Gene start: 74097035
Gene end: 74099293
  
Corresponding Affymetrix probe sets: 1569203_at (Human Genome U133 Plus 2.0 Array)   209774_x_at (Human Genome U133 Plus 2.0 Array)   230101_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427279
NCBI entrez gene - 2920     See in Manteia.
OMIM - 139110
RefSeq - NM_002089
RefSeq Peptide - NP_002080
swissprot - A0A024RDD9
swissprot - P19875
Ensembl - ENSG00000081041
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcl19ENSDARG00000102776Danio rerio
 ENSGALG00000046160Gallus gallus
 Cxcl1ENSMUSG00000029380Mus musculus
 Cxcl2ENSMUSG00000058427Mus musculus
 Cxcl3ENSMUSG00000029379Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CXCL1 / P09341 / C-X-C motif chemokine ligand 1ENSG0000016373990
CXCL3 / P19876 / C-X-C motif chemokine ligand 3ENSG0000016373488
PPBP / P02775 / pro-platelet basic proteinENSG0000016373647
CXCL5 / P42830 / C-X-C motif chemokine ligand 5ENSG0000016373544
CXCL6 / P80162 / C-X-C motif chemokine ligand 6ENSG0000012487538
CXCL8 / P10145 / C-X-C motif chemokine ligand 8ENSG0000016942936


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR018048  CXC chemokine, conserved site
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002237 response to molecule of bacterial origin IDA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity TAS
 molecular_functionGO:0045236 CXCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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