ENSG00000163736


Homo sapiens

Features
Gene ID: ENSG00000163736
  
Biological name :PPBP
  
Synonyms : P02775 / PPBP / pro-platelet basic protein
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q13.3
Gene start: 73987038
Gene end: 73988197
  
Corresponding Affymetrix probe sets: 214146_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296028
NCBI entrez gene - 5473     See in Manteia.
OMIM - 121010
RefSeq - NM_002704
RefSeq Peptide - NP_002695
swissprot - P02775
Ensembl - ENSG00000163736
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcl19ENSDARG00000102776Danio rerio
 ENSGALG00000046160Gallus gallus
 PpbpENSMUSG00000029372Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CXCL1 / P09341 / C-X-C motif chemokine ligand 1ENSG0000016373941
CXCL2 / P19875 / C-X-C motif chemokine ligand 2ENSG0000008104139
CXCL5 / P42830 / C-X-C motif chemokine ligand 5ENSG0000016373538
CXCL3 / P19876 / C-X-C motif chemokine ligand 3ENSG0000016373438
CXCL6 / P80162 / C-X-C motif chemokine ligand 6ENSG0000012487534
CXCL8 / P10145 / C-X-C motif chemokine ligand 8ENSG0000016942931


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR018048  CXC chemokine, conserved site
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IBA
 biological_processGO:1904659 glucose transmembrane transport TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 cellular_componentGO:1904724 tertiary granule lumen TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005355 glucose transmembrane transporter activity TAS
 molecular_functionGO:0008009 chemokine activity IBA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0045236 CXCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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