ENSMUSG00000029372


Mus musculus

Features
Gene ID: ENSMUSG00000029372
  
Biological name :Ppbp
  
Synonyms : Ppbp / pro-platelet basic protein
  
Possible biological names infered from orthology : P02775
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 90768518
Gene end: 90770063
  
Corresponding Affymetrix probe sets: 10523128 (MoGene1.0st)   1418480_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031319
NCBI entrez gene - 57349     See in Manteia.
MGI - MGI:1888712
RefSeq - NM_023785
RefSeq Peptide - NP_076274
swissprot - Q9EQI5
Ensembl - ENSMUSG00000029372
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PPBPENSG00000163736Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cxcl2 / P10889 / C-X-C motif chemokine 2 / CXCL3* / CXCL1* / P19876* / P09341* / P19875* / C-X-C motif chemokine ligand 2* / C-X-C motif chemokine ligand 3* / C-X-C motif chemokine ligand 1*ENSMUSG0000005842738
Cxcl1 / P12850 / Growth-regulated alpha protein KC(5-72) / CXCL3* / CXCL2* / P19876* / P09341* / P19875* / C-X-C motif chemokine ligand 2* / C-X-C motif chemokine ligand 1* / C-X-C motif ch...ENSMUSG0000002938035
Cxcl3 / Q6W5C0 / C-X-C motif chemokine 3 / CXCL1* / CXCL2* / P09341* / P19875* / P19876* / C-X-C motif chemokine ligand 3* / C-X-C motif chemokine ligand 2* / C-X-C motif chemokine ligand 1*ENSMUSG0000002937935
Cxcl5 / P50228 / C-X-C motif chemokine 5 GCP-2(1-78) GCP-2(9-78) / CXCL6* / P80162* / P42830* / C-X-C motif chemokine ligand 6* / C-X-C motif chemokine ligand 5*ENSMUSG0000002937132
Cxcl15 / Q9WVL7 / C-X-C motif chemokine 15 ENSMUSG0000002937527


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IMP
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0008009 chemokine activity IDA
 molecular_functionGO:0045236 CXCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Albtm1(cre/ERT2)Mtz/Albtm1(cre/ERT2)Mtz,Slc2a2tm2Thor/Slc2a2tm2Thor
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Pik3c2atm1b(EUCOMM)Hmgu/Pik3c2a+
Genetic Background: C57BL/6N-Pik3c2atm1b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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