Manteia

ENSMUSG00000029380

Mus musculus

Features

Gene ID:	ENSMUSG00000029380

Biological name :	Cxcl1

Synonyms :	Cxcl1 / Growth-regulated alpha protein KC(5-72) / P12850

Possible biological names infered from orthology :	CXCL2 / CXCL3 / C-X-C motif chemokine ligand 1 / C-X-C motif chemokine ligand 2 / C-X-C motif chemokine ligand 3 / P09341 / P19875 / P19876

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	E1
Gene start:	90891241
Gene end:	90893115

Corresponding Affymetrix probe sets:	10523151 (MoGene1.0st) 1419209_at (Mouse Genome 430 2.0 Array) 1441855_x_at (Mouse Genome 430 2.0 Array) 1457644_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000031327 NCBI entrez gene - 14825 See in Manteia. MGI - MGI:108068 RefSeq - NM_008176 RefSeq Peptide - NP_032202 swissprot - A2RTH0 swissprot - P12850 Ensembl - ENSMUSG00000029380

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Cxcl2 / P10889 / C-X-C motif chemokine 2 / CXCL3* / CXCL1* / P19876* / P09341* / P19875* / C-X-C motif chemokine ligand 2* / C-X-C motif chemokine ligand 3* / C-X-C motif chemokine ligand 1*	ENSMUSG00000058427	67
Cxcl3 / Q6W5C0 / C-X-C motif chemokine 3 / CXCL1* / CXCL2* / P09341* / P19875* / P19876* / C-X-C motif chemokine ligand 3* / C-X-C motif chemokine ligand 2* / C-X-C motif chemokine ligand 1*	ENSMUSG00000029379	59
Cxcl5 / P50228 / C-X-C motif chemokine 5 GCP-2(1-78) GCP-2(9-78) / CXCL6* / P80162* / P42830* / C-X-C motif chemokine ligand 6* / C-X-C motif chemokine ligand 5*	ENSMUSG00000029371	44
Ppbp / pro-platelet basic protein / P02775*	ENSMUSG00000029372	41
Cxcl15 / Q9WVL7 / C-X-C motif chemokine 15	ENSMUSG00000029375	32

Protein motifs (from Interpro)

Interpro ID	Name
IPR001089	CXC chemokine
IPR001811	Chemokine interleukin-8-like domain
IPR018048	CXC chemokine, conserved site
IPR033899	CXC Chemokine domain
IPR036048	Chemokine interleukin-8-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002237	response to molecule of bacterial origin	ISO
biological_process	GO:0006935	chemotaxis	IEA
biological_process	GO:0006952	defense response	IEA
biological_process	GO:0006954	inflammatory response	IBA
biological_process	GO:0006955	immune response	IBA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IBA
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0032496	response to lipopolysaccharide	IBA
biological_process	GO:0032930	positive regulation of superoxide anion generation	IDA
biological_process	GO:0060326	cell chemotaxis	IEA
biological_process	GO:0070098	chemokine-mediated signaling pathway	IBA
biological_process	GO:0070965	positive regulation of neutrophil mediated killing of fungus	IDA
biological_process	GO:0090023	positive regulation of neutrophil chemotaxis	IBA
biological_process	GO:1902035	positive regulation of hematopoietic stem cell proliferation	IDA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
molecular_function	GO:0005125	cytokine activity	IEA
molecular_function	GO:0008009	chemokine activity	IBA
molecular_function	GO:0008083	growth factor activity	IEA
molecular_function	GO:0045236	CXCR chemokine receptor binding	IBA

Pathways (from Reactome)

Pathway description

Chemokine receptors bind chemokines

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0005338	atherosclerotic lesions	"thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ncstn^tm1Rroz/Ncstn^tm1Rroz Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0005341	decreased susceptibility to atherosclerosis	"less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cxcl1^tm1Wabo/Cxcl1^tm1Wabo,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr