ENSDARG00000104795


Danio rerio

Features
Gene ID: ENSDARG00000104795
  
Biological name :cxcl8a
  
Synonyms : chemokine (C-X-C motif) ligand 8a / cxcl8a
  
Possible biological names infered from orthology : CXCL8 / C-X-C motif chemokine ligand 8 / P10145
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 14253118
Gene end: 14254166
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000137520
NCBI entrez gene - 100002946     See in Manteia.
RefSeq - XM_001342570
RefSeq - XM_009306855
swissprot - A0A0G2KYH9
ZFIN ID - ZDB-GENE-081104-317
Ensembl - ENSDARG00000104795
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL8ENSGALG00000026098Gallus gallus
 IL8L1ENSGALG00000011668Gallus gallus
 CXCL8ENSG00000169429Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cxcl19 / chemokine (C-X-C motif) ligand 19 / PPBP* / CXCL2* / CXCL3* / CXCL5* / CXCL6* / CXCL1* / Q9WVL7* / Cxcl15* / P02775* / P09341* / P19875* / P19876* / P42830* / P80162* / C-X-C motif...ENSDARG0000010277633


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR028469  Interleukin-8
 IPR033899  CXC Chemokine domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IMP
 biological_processGO:0002631 regulation of granuloma formation IMP
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IBA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0009611 response to wounding IMP
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0060218 hematopoietic stem cell differentiation IMP
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0071305 cellular response to vitamin D IMP
 biological_processGO:0071621 granulocyte chemotaxis IDA
 biological_processGO:0098508 endothelial to hematopoietic transition IMP
 biological_processGO:1990266 neutrophil migration IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0008009 chemokine activity IDA
 molecular_functionGO:0045236 CXCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood neutrophil increased amount , abnormal
Show

 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm hematopoietic stem cell increased amount , abnormal
intermediate cell mass of mesoderm hematopoietic multipotent progenitor cell increased amount , abnormal
Show

 ZFA:0001058 caudal fin caudal fin neutrophil decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism decreased life span , abnormal
whole organism decreased life span , exacerbated
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel malformed , abnormal
intersegmental vessel morphology , abnormal
Show

 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel malformed , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta angioblastic mesenchymal cell decreased amount , abnormal
ventral wall of dorsal aorta has normal numbers of parts of type hematopoietic multipotent progenitor cell , ameliorated
Show

 ZFA:0009327 neutrophil neutrophil immune response process quality , abnormal
neutrophil response to bacterium process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000054975 cxcr2 / chemokine (C-X-C motif) receptor 2 / CXCR1* / P25024* / P25025* / P35343* / Q810W6* / C-X-C chemokine receptor type 1 * / C-X-C motif chemokine receptor 2* / C-X-C chemokine recepto...  / complex / reaction






 

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