ENSG00000129048


Homo sapiens

Features
Gene ID: ENSG00000129048
  
Biological name :ACKR4
  
Synonyms : ACKR4 / atypical chemokine receptor 4 / Q9NPB9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q22.1
Gene start: 132597237
Gene end: 132618967
  
Corresponding Affymetrix probe sets: 220351_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000249887
Ensembl peptide - ENSP00000425557
NCBI entrez gene - 51554     See in Manteia.
OMIM - 606065
RefSeq - NM_016557
RefSeq - NM_178445
RefSeq Peptide - NP_057641
RefSeq Peptide - NP_848540
swissprot - Q9NPB9
swissprot - H0Y9Z2
Ensembl - ENSG00000129048
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ackr4aENSDARG00000078729Danio rerio
 ackr4bENSDARG00000040133Danio rerio
 ACKR4ENSGALG00000041491Gallus gallus
 Ackr4ENSMUSG00000079355Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCR7 / P32248 / C-C motif chemokine receptor 7ENSG0000012635339
CCR6 / P51684 / C-C motif chemokine receptor 6ENSG0000011248634
CCR9 / P51686 / C-C motif chemokine receptor 9ENSG0000017358534
CCR10 / P46092 / C-C motif chemokine receptor 10ENSG0000018445132
CXCR6 / O00574 / C-X-C motif chemokine receptor 6ENSG0000017221532
CXCR2 / P25025 / C-X-C motif chemokine receptor 2ENSG0000018087131
CX3CR1 / P49238 / C-X3-C motif chemokine receptor 1ENSG0000016832931
CXCR4 / P61073 / C-X-C motif chemokine receptor 4ENSG0000012196631
CCR4 / P51679 / C-C motif chemokine receptor 4ENSG0000018381331
ACKR2 / O00590 / atypical chemokine receptor 2ENSG0000014464830
CCR1 / P32246 / C-C motif chemokine receptor 1ENSG0000016382330
CCR2 / P41597 / C-C motif chemokine receptor 2ENSG0000012180729
CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)ENSG0000016079129
CCR8 / P51685 / C-C motif chemokine receptor 8ENSG0000017993429
CXCR1 / P25024 / C-X-C motif chemokine receptor 1ENSG0000016346429
CXCR3 / P49682 / C-X-C motif chemokine receptor 3ENSG0000018681028
CXCR5 / P32302 / C-X-C motif chemokine receptor 5ENSG0000016068328
CCR3 / P51677 / C-C motif chemokine receptor 3ENSG0000018362527
XCR1 / P46094 / X-C motif chemokine receptor 1ENSG0000017357823


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR005383  Atypical chemokine receptor 4
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IDA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019956 chemokine binding IEA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137077 CCL21 / O00585 / C-C motif chemokine ligand 21  / complex / reaction
 ENSG00000131142 CCL25 / O15444 / C-C motif chemokine ligand 25  / reaction / complex
 ENSG00000172724 CCL19 / Q99731 / C-C motif chemokine ligand 19  / reaction / complex






 

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