ENSG00000173578


Homo sapiens

Features
Gene ID: ENSG00000173578
  
Biological name :XCR1
  
Synonyms : P46094 / X-C motif chemokine receptor 1 / XCR1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 46017024
Gene end: 46027742
  
Corresponding Affymetrix probe sets: 1561226_at (Human Genome U133 Plus 2.0 Array)   221468_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000310405
Ensembl peptide - ENSP00000379277
NCBI entrez gene - 2829     See in Manteia.
OMIM - 600552
RefSeq - XM_017006201
RefSeq - NM_001024644
RefSeq - NM_005283
RefSeq - XM_017006197
RefSeq - XM_017006198
RefSeq - XM_017006199
RefSeq - XM_017006200
RefSeq - XM_017006196
RefSeq Peptide - NP_005274
RefSeq Peptide - NP_001019815
swissprot - P46094
swissprot - Q689E2
Ensembl - ENSG00000173578
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xcr1a.1ENSDARG00000054847Danio rerio
 xcr1b.1ENSDARG00000052988Danio rerio
 XCR1ENSGALG00000011735Gallus gallus
 Xcr1ENSMUSG00000060509Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ACKR2 / O00590 / atypical chemokine receptor 2ENSG0000014464835
CX3CR1 / P49238 / C-X3-C motif chemokine receptor 1ENSG0000016832934
CCR8 / P51685 / C-C motif chemokine receptor 8ENSG0000017993434
CCR1 / P32246 / C-C motif chemokine receptor 1ENSG0000016382334
CCR4 / P51679 / C-C motif chemokine receptor 4ENSG0000018381333
CCR3 / P51677 / C-C motif chemokine receptor 3ENSG0000018362533
CCR2 / P41597 / C-C motif chemokine receptor 2ENSG0000012180732
CXCR1 / P25024 / C-X-C motif chemokine receptor 1ENSG0000016346431
CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)ENSG0000016079131
CXCR2 / P25025 / C-X-C motif chemokine receptor 2ENSG0000018087131
CXCR4 / P61073 / C-X-C motif chemokine receptor 4ENSG0000012196629
CXCR5 / P32302 / C-X-C motif chemokine receptor 5ENSG0000016068328
CCR6 / P51684 / C-C motif chemokine receptor 6ENSG0000011248628
CXCR6 / O00574 / C-X-C motif chemokine receptor 6ENSG0000017221528
CCR10 / P46092 / C-C motif chemokine receptor 10ENSG0000018445127
CXCR3 / P49682 / C-X-C motif chemokine receptor 3ENSG0000018681027
CCR7 / P32248 / C-C motif chemokine receptor 7ENSG0000012635327
CCR9 / P51686 / C-C motif chemokine receptor 9ENSG0000017358525
ACKR4 / Q9NPB9 / atypical chemokine receptor 4ENSG0000012904824


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005393  XC chemokine receptor 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration TAS
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity TAS


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000143184 XCL1 / P47992 / X-C motif chemokine ligand 1  / complex / reaction
 ENSG00000143185 XCL2 / Q9UBD3 / X-C motif chemokine ligand 2  / reaction / complex






 

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