Manteia

ENSG00000126353

Homo sapiens

Features

Gene ID:	ENSG00000126353

Biological name :	CCR7

Synonyms :	C-C motif chemokine receptor 7 / CCR7 / P32248

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	17
Strand:	-1
Band:	q21.2
Gene start:	40553769
Gene end:	40565472

Corresponding Affymetrix probe sets:	206337_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000463075 Ensembl peptide - ENSP00000246657 Ensembl peptide - ENSP00000462631 NCBI entrez gene - 1236 See in Manteia. OMIM - 600242 RefSeq - NM_001301716 RefSeq - NM_001301714 RefSeq - NM_001301717 RefSeq - NM_001301718 RefSeq - NM_001838 RefSeq Peptide - NP_001288647 RefSeq Peptide - NP_001829 RefSeq Peptide - NP_001288643 RefSeq Peptide - NP_001288645 RefSeq Peptide - NP_001288646 swissprot - J3KSS9 swissprot - P32248 swissprot - J3KTN5 swissprot - A0N0Q0 Ensembl - ENSG00000126353

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ccr7	ENSDARG00000044561	Danio rerio
CCR7	ENSGALG00000035733	Gallus gallus
Ccr7	ENSMUSG00000037944	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
CCR9 / P51686 / C-C motif chemokine receptor 9	ENSG00000173585	40
CCR6 / P51684 / C-C motif chemokine receptor 6	ENSG00000112486	39
ACKR4 / Q9NPB9 / atypical chemokine receptor 4	ENSG00000129048	36
CCR10 / P46092 / C-C motif chemokine receptor 10	ENSG00000184451	34
CCR2 / P41597 / C-C motif chemokine receptor 2	ENSG00000121807	34
CXCR2 / P25025 / C-X-C motif chemokine receptor 2	ENSG00000180871	33
CCR1 / P32246 / C-C motif chemokine receptor 1	ENSG00000163823	33
CXCR3 / P49682 / C-X-C motif chemokine receptor 3	ENSG00000186810	33
CCR4 / P51679 / C-C motif chemokine receptor 4	ENSG00000183813	32
CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)	ENSG00000160791	32
CCR3 / P51677 / C-C motif chemokine receptor 3	ENSG00000183625	31
CX3CR1 / P49238 / C-X3-C motif chemokine receptor 1	ENSG00000168329	31
CXCR1 / P25024 / C-X-C motif chemokine receptor 1	ENSG00000163464	31
CXCR5 / P32302 / C-X-C motif chemokine receptor 5	ENSG00000160683	31
CXCR6 / O00574 / C-X-C motif chemokine receptor 6	ENSG00000172215	31
CXCR4 / P61073 / C-X-C motif chemokine receptor 4	ENSG00000121966	30
ACKR2 / O00590 / atypical chemokine receptor 2	ENSG00000144648	29
CCR8 / P51685 / C-C motif chemokine receptor 8	ENSG00000179934	27
XCR1 / P46094 / X-C motif chemokine receptor 1	ENSG00000173578	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR000355	Chemokine receptor family
IPR001718	CC chemokine receptor 7
IPR017452	GPCR, rhodopsin-like, 7TM

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001768	establishment of T cell polarity	IC
biological_process	GO:0001954	positive regulation of cell-matrix adhesion	IC
biological_process	GO:0002407	dendritic cell chemotaxis	IC
biological_process	GO:0002408	myeloid dendritic cell chemotaxis	IDA
biological_process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	ISS
biological_process	GO:0002885	positive regulation of hypersensitivity	ISS
biological_process	GO:0002922	positive regulation of humoral immune response	ISS
biological_process	GO:0006935	chemotaxis	IEA
biological_process	GO:0006954	inflammatory response	IEA
biological_process	GO:0006955	immune response	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007204	positive regulation of cytosolic calcium ion concentration	TAS
biological_process	GO:0030838	positive regulation of actin filament polymerization	IC
biological_process	GO:0031274	positive regulation of pseudopodium assembly	IC
biological_process	GO:0031529	ruffle organization	IC
biological_process	GO:0032496	response to lipopolysaccharide	IEA
biological_process	GO:0032649	regulation of interferon-gamma production	ISS
biological_process	GO:0032735	positive regulation of interleukin-12 production	ISS
biological_process	GO:0034695	response to prostaglandin E	IC
biological_process	GO:0038115	chemokine (C-C motif) ligand 19 signaling pathway	IEA
biological_process	GO:0038116	chemokine (C-C motif) ligand 21 signaling pathway	IEA
biological_process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IC
biological_process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IC
biological_process	GO:0045060	negative thymic T cell selection	IEA
biological_process	GO:0045785	positive regulation of cell adhesion	IC
biological_process	GO:0045860	positive regulation of protein kinase activity	IC
biological_process	GO:0046330	positive regulation of JNK cascade	IC
biological_process	GO:0048872	homeostasis of number of cells	IEA
biological_process	GO:0050706	regulation of interleukin-1 beta secretion	ISS
biological_process	GO:0050862	positive regulation of T cell receptor signaling pathway	IEA
biological_process	GO:0051209	release of sequestered calcium ion into cytosol	IC
biological_process	GO:0051491	positive regulation of filopodium assembly	IC
biological_process	GO:0051897	positive regulation of protein kinase B signaling	IC
biological_process	GO:0070098	chemokine-mediated signaling pathway	IEA
biological_process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IC
biological_process	GO:0071345	cellular response to cytokine stimulus	IDA
biological_process	GO:0071731	response to nitric oxide	IC
biological_process	GO:0072610	interleukin-12 secretion	ISS
biological_process	GO:0090023	positive regulation of neutrophil chemotaxis	IDA
biological_process	GO:0090630	activation of GTPase activity	IC
biological_process	GO:0097022	lymphocyte migration into lymph node	TAS
biological_process	GO:0097029	mature conventional dendritic cell differentiation	ISS
biological_process	GO:2000147	positive regulation of cell motility	IC
biological_process	GO:2000510	positive regulation of dendritic cell chemotaxis	ISS
biological_process	GO:2000522	positive regulation of immunological synapse formation	ISS
biological_process	GO:2000525	positive regulation of T cell costimulation	ISS
biological_process	GO:2000526	positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	ISS
biological_process	GO:2000547	regulation of dendritic cell dendrite assembly	ISS
biological_process	GO:2000669	negative regulation of dendritic cell apoptotic process	IC
cellular_component	GO:0005622	intracellular	IDA
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005886	plasma membrane	IDA
cellular_component	GO:0009897	external side of plasma membrane	IEA
cellular_component	GO:0009986	cell surface	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0004950	chemokine receptor activity	IEA
molecular_function	GO:0016493	C-C chemokine receptor activity	IEA
molecular_function	GO:0035757	chemokine (C-C motif) ligand 19 binding	IPI
molecular_function	GO:0035758	chemokine (C-C motif) ligand 21 binding	IPI
molecular_function	GO:0038117	C-C motif chemokine 19 receptor activity	IDA
molecular_function	GO:0038121	C-C motif chemokine 21 receptor activity	IDA

Pathways (from Reactome)

Pathway description

Chemokine receptors bind chemokines

G alpha (i) signalling events

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000172724	CCL19 / Q99731 / C-C motif chemokine ligand 19	/ complex / reaction
ENSG00000137077	CCL21 / O00585 / C-C motif chemokine ligand 21	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr