ENSG00000137077


Homo sapiens

Features
Gene ID: ENSG00000137077
  
Biological name :CCL21
  
Synonyms : CCL21 / C-C motif chemokine ligand 21 / O00585
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: p13.3
Gene start: 34709005
Gene end: 34710124
  
Corresponding Affymetrix probe sets: 204606_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000259607
Ensembl peptide - ENSP00000368069
NCBI entrez gene - 6366     See in Manteia.
OMIM - 602737
RefSeq - XM_011518004
RefSeq - NM_002989
RefSeq Peptide - NP_002980
swissprot - O00585
swissprot - Q5VZ73
swissprot - Q6ICR7
Ensembl - ENSG00000137077
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ccl21aENSMUSG00000094686Mus musculus
 Ccl21bENSMUSG00000095675Mus musculus
 P86792ENSMUSG00000096596Mus musculus
 P86792ENSMUSG00000073878Mus musculus
 P86792ENSMUSG00000094065Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001811  Chemokine interleukin-8-like domain
 IPR030593  C-C motif chemokine 21
 IPR034133  Chemokine CC, DCCL motif-cointaining domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001768 establishment of T cell polarity IDA
 biological_processGO:0001771 immunological synapse formation ISS
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IDA
 biological_processGO:0002407 dendritic cell chemotaxis IDA
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010560 positive regulation of glycoprotein biosynthetic process ISS
 biological_processGO:0030838 positive regulation of actin filament polymerization IDA
 biological_processGO:0031274 positive regulation of pseudopodium assembly IDA
 biological_processGO:0031295 T cell costimulation ISS
 biological_processGO:0031529 ruffle organization IDA
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin IDA
 biological_processGO:0034695 response to prostaglandin E IDA
 biological_processGO:0035759 mesangial cell-matrix adhesion IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IDA
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0048247 lymphocyte chemotaxis IBA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis ISS
 biological_processGO:0048469 cell maturation ISS
 biological_processGO:0050921 positive regulation of chemotaxis ISS
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IDA
 biological_processGO:0051491 positive regulation of filopodium assembly IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IDA
 biological_processGO:0090630 activation of GTPase activity IDA
 biological_processGO:0097026 dendritic cell dendrite assembly ISS
 biological_processGO:1903237 negative regulation of leukocyte tethering or rolling IDA
 biological_processGO:2000147 positive regulation of cell motility IDA
 biological_processGO:2000406 positive regulation of T cell migration IDA
 biological_processGO:2000529 positive regulation of myeloid dendritic cell chemotaxis IDA
 biological_processGO:2000548 negative regulation of dendritic cell dendrite assembly ISS
 biological_processGO:2000669 negative regulation of dendritic cell apoptotic process IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity IEA
 molecular_functionGO:0031732 CCR7 chemokine receptor binding IEA
 molecular_functionGO:0042379 chemokine receptor binding IDA
 molecular_functionGO:0048020 CCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000126353 CCR7 / P32248 / C-C motif chemokine receptor 7  / reaction / complex
 ENSG00000129048 ACKR4 / Q9NPB9 / atypical chemokine receptor 4  / complex / reaction






 

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