ENSMUSG00000094686


Mus musculus

Features
Gene ID: ENSMUSG00000094686
  
Biological name :Ccl21a
  
Synonyms : Ccl21a / C-C motif chemokine 21a / P84444
  
Possible biological names infered from orthology : CCL21 / C-C motif chemokine ligand 21 / O00585
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 42772860
Gene end: 42773993
  
Corresponding Affymetrix probe sets: 10504127 (MoGene1.0st)   10504154 (MoGene1.0st)   10504183 (MoGene1.0st)   10512377 (MoGene1.0st)   1419426_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092732
NCBI entrez gene - 18829     See in Manteia.
MGI - MGI:1349183
RefSeq - NM_011124
RefSeq Peptide - NP_035254
swissprot - P84444
Ensembl - ENSMUSG00000094686
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCL21ENSG00000137077Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P86792 / P86793 / Gm10591 / predicted gene 10591 / CCL21* / O00585* / C-C motif chemokine ligand 21*ENSMUSG0000009659699
P86792 / P86793 / Gm21541 / predicted gene, 21541 / CCL21* / O00585* / C-C motif chemokine ligand 21*ENSMUSG0000009406599
Ccl21b / P86793 / P86792 / C-C motif chemokine 21b / CCL21* / O00585* / C-C motif chemokine ligand 21*ENSMUSG0000009567599
P86792 / P86793 / Gm13304 / predicted gene 13304 / CCL21* / O00585* / C-C motif chemokine ligand 21*ENSMUSG0000007387899


Protein motifs (from Interpro)
Interpro ID Name
 IPR001811  Chemokine interleukin-8-like domain
 IPR030593  C-C motif chemokine 21
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001768 establishment of T cell polarity ISS
 biological_processGO:0001771 immunological synapse formation IDA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion ISS
 biological_processGO:0002407 dendritic cell chemotaxis IDA
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation IDA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010560 positive regulation of glycoprotein biosynthetic process IDA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis NAS
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0030838 positive regulation of actin filament polymerization ISS
 biological_processGO:0031274 positive regulation of pseudopodium assembly ISS
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0031529 ruffle organization ISS
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin ISS
 biological_processGO:0034695 response to prostaglandin E ISS
 biological_processGO:0035759 mesangial cell-matrix adhesion ISS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISS
 biological_processGO:0045860 positive regulation of protein kinase activity ISS
 biological_processGO:0046330 positive regulation of JNK cascade ISS
 biological_processGO:0048247 lymphocyte chemotaxis IBA
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IDA
 biological_processGO:0048469 cell maturation IDA
 biological_processGO:0048535 lymph node development IMP
 biological_processGO:0050921 positive regulation of chemotaxis IDA
 biological_processGO:0050930 induction of positive chemotaxis IDA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol ISS
 biological_processGO:0051491 positive regulation of filopodium assembly ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISS
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis ISS
 biological_processGO:0090630 activation of GTPase activity ISS
 biological_processGO:0097026 dendritic cell dendrite assembly IDA
 biological_processGO:2000147 positive regulation of cell motility ISS
 biological_processGO:2000406 positive regulation of T cell migration ISO
 biological_processGO:2000529 positive regulation of myeloid dendritic cell chemotaxis ISS
 biological_processGO:2000548 negative regulation of dendritic cell dendrite assembly IDA
 biological_processGO:2000669 negative regulation of dendritic cell apoptotic process ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IDA
 molecular_functionGO:0031732 CCR7 chemokine receptor binding IPI
 molecular_functionGO:0042379 chemokine receptor binding ISO


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0012765 decreased alpha-beta T cell number "reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

 MP:0020220 decreased tear production "decreased production of the amount of fluid produced in the eye" [GOC:NV]
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Allelic Composition: Trim25tm1Mura/Trim25+,Usp15L749R/Usp15+
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000079355 Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*  / reaction / complex
 ENSMUSG00000037944 Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*  / reaction / complex






 

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