ENSMUSG00000037944


Mus musculus

Features
Gene ID: ENSMUSG00000037944
  
Biological name :Ccr7
  
Synonyms : C-C chemokine receptor type 7 / Ccr7 / P47774
  
Possible biological names infered from orthology : C-C motif chemokine receptor 7 / P32248
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 99144196
Gene end: 99155077
  
Corresponding Affymetrix probe sets: 10390763 (MoGene1.0st)   1423466_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099423
NCBI entrez gene - 12775     See in Manteia.
MGI - MGI:103011
RefSeq - NM_007719
RefSeq - NM_001301713
RefSeq Peptide - NP_001288642
RefSeq Peptide - NP_031745
swissprot - P47774
Ensembl - ENSMUSG00000037944
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccr7ENSDARG00000044561Danio rerio
 CCR7ENSGALG00000035733Gallus gallus
 CCR7ENSG00000126353Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953039
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089937
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852135
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405234
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935534
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789832
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788031
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618031
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580431
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910331
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922731
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023230
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544830
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848030
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403929
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538229
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233628
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226228
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453427
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050924


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR001718  CC chemokine receptor 7
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001768 establishment of T cell polarity TAS
 biological_processGO:0002408 myeloid dendritic cell chemotaxis IEA
 biological_processGO:0002518 lymphocyte chemotaxis across high endothelial venule TAS
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation IDA
 biological_processGO:0002649 regulation of tolerance induction to self antigen TAS
 biological_processGO:0002885 positive regulation of hypersensitivity IMP
 biological_processGO:0002922 positive regulation of humoral immune response IMP
 biological_processGO:0006935 chemotaxis IMP
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007257 activation of JUN kinase activity IC
 biological_processGO:0010759 positive regulation of macrophage chemotaxis NAS
 biological_processGO:0010820 positive regulation of T cell chemotaxis TAS
 biological_processGO:0030036 actin cytoskeleton organization TAS
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0032649 regulation of interferon-gamma production IMP
 biological_processGO:0032735 positive regulation of interleukin-12 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IC
 biological_processGO:0034695 response to prostaglandin E TAS
 biological_processGO:0038115 chemokine (C-C motif) ligand 19 signaling pathway IEA
 biological_processGO:0038116 chemokine (C-C motif) ligand 21 signaling pathway IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IC
 biological_processGO:0043547 positive regulation of GTPase activity IC
 biological_processGO:0045060 negative thymic T cell selection IMP
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation IC
 biological_processGO:0048260 positive regulation of receptor-mediated endocytosis IC
 biological_processGO:0048535 lymph node development TAS
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0050706 regulation of interleukin-1 beta secretion IMP
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IC
 biological_processGO:0050766 positive regulation of phagocytosis NAS
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IMP
 biological_processGO:0051491 positive regulation of filopodium assembly TAS
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071731 response to nitric oxide TAS
 biological_processGO:0072610 interleukin-12 secretion IMP
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 biological_processGO:0097022 lymphocyte migration into lymph node TAS
 biological_processGO:0097029 mature conventional dendritic cell differentiation IMP
 biological_processGO:2000107 negative regulation of leukocyte apoptotic process TAS
 biological_processGO:2000147 positive regulation of cell motility TAS
 biological_processGO:2000412 positive regulation of thymocyte migration TAS
 biological_processGO:2000510 positive regulation of dendritic cell chemotaxis IMP
 biological_processGO:2000522 positive regulation of immunological synapse formation IMP
 biological_processGO:2000525 positive regulation of T cell costimulation IMP
 biological_processGO:2000526 positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation IMP
 biological_processGO:2000547 regulation of dendritic cell dendrite assembly IC
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0004950 chemokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016493 C-C chemokine receptor activity IMP
 molecular_functionGO:0035757 chemokine (C-C motif) ligand 19 binding IEA
 molecular_functionGO:0035758 chemokine (C-C motif) ligand 21 binding IEA
 molecular_functionGO:0038117 C-C motif chemokine 19 receptor activity IEA
 molecular_functionGO:0038121 C-C motif chemokine 21 receptor activity IEA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001346 abnormal lacrimal gland morphology "malformation of the glands that secrete tears" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: ApcMin/Apc+,Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002343 abnormal lymph node cortex "anomaly in the outer area of the lymph node that has B and T cell domains" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002347 abnormal lymph node T cell domain "anomaly in the area of the lymph node in which T lymphocytes reside" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002363 abnormal spleen marginal sinus morphology "anomalous structure of the area of the spleen through which blood enters" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Col1a1tm1(CAG-Sirt1)Dsin/Col1a1+,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor
Genetic Background: B6.129P2-Ccr7tm1Rfor

 MP:0002392 abnormal Peyer s patch T cell area "anomalous structure or development of the Peyer s patch normally occupied by T lymphcytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Runx2tm1.1Yyon/Runx2tm1.1Yyon,Tg(Col2a1-cre)1Star/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Tyrc-Bc2/Tyrc-Bc2
Genetic Background: SELH/Bc

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd7tm1Bfh/Cd7tm1Bfh
Genetic Background: B6.129-Cd7tm1Bfh

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor
Genetic Background: B6.129P2-Ccr7tm1Rfor

 MP:0003452 abnormal parotid gland morphology "malformation of either of the largest of the major salivary glands situated below and in front of each ear and opening into the parotid duct" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94478]
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Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor
Genetic Background: B6.129P2-Ccr7tm1Rfor

 MP:0003793 abnormal submandibular gland morphology "any structural malformation of either of the large major salivary glands situated beneath the mandible" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor
Genetic Background: B6.129P2-Ccr7tm1Rfor

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Atp2b2m1Btlr/Atp2b2m1Btlr
Genetic Background: C57BL/6J-Atp2b2m1Btlr

Allelic Composition: Ccr7m1Btlr/Ccr7+
Genetic Background: C57BL/6J-Ccr7m1Btlr

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor,Tg(DO11.10)10Dlo/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor
Genetic Background: B6.129P2-Ccr7tm1Rfor

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2m1Btlr/Atp2b2m1Btlr
Genetic Background: C57BL/6J-Atp2b2m1Btlr

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Styxtm1.1Jedi/Styxtm1.1Jedi
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: C57BL/6)

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor
Genetic Background: B6.129P2-Ccr7tm1Rfor

 MP:0008879 submandibular gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor
Genetic Background: B6.129P2-Ccr7tm1Rfor

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor
Genetic Background: B6.129P2-Ccr7tm1Rfor

 MP:0010740 abnormal dendritic cell chemotaxis "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
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Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0013367 parotid gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in either of the largest of the major salivary glands situated below and in front of each ear " [MGI:Anna]
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Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor
Genetic Background: B6.129P2-Ccr7tm1Rfor

 MP:0013558 abnormal exocrine gland morphology "any structural anomaly of any of the glands of the exocrine system that secrete their essential product by way of a duct to some environment external to itself, either inside the body or on a surface of the body; the duct portion may be branched (compound) or unbranched (simple); the glandular portion may be tubular or acinar, or may be a mix of the two (tubuloacinar or tubuloalveolar); if the glandular portion branches, then the gland is called a branched gland Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas" [http://en.wikipedia.org/wiki/Exocrine_gland, MGI:Anna]
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Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor
Genetic Background: B6.129P2-Ccr7tm1Rfor

 MP:0013588 small thymus medulla "decreased size of the inner area of thymus lobules" [MGI:Anna]
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Allelic Composition: Ccr7tm1Rfor/Ccr7tm1Rfor
Genetic Background: B6.129P2-Ccr7tm1Rfor

 MP:0013649 decreased CD11b-high dendritic cell number "reduction in the number of dendritic cells expressing high levels of CD11b which usually depend on Irf4 for their development" [MGI:Saran, PMID:23516985]
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Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0013655 decreased CD103-positive CD11b-low dendritic cell number "reduction in the number of CD11b-low dendritic cells expressing CD103, a marker of tissue residency" [MGI:Saran, PMID:23516985]
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Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000096596 P86792 / P86793 / Gm10591 / predicted gene 10591 / CCL21* / O00585* / C-C motif chemokine ligand 21*  / reaction / complex
 ENSMUSG00000094686 P84444 / Ccl21a / C-C motif chemokine 21a / CCL21* / O00585* / C-C motif chemokine ligand 21*  / complex / reaction
 ENSMUSG00000071005 Ccl19 / O70460 / C-C motif chemokine 19 / Q99731* / C-C motif chemokine ligand 19*  / reaction / complex






 

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