ENSMUSG00000029530


Mus musculus

Features
Gene ID: ENSMUSG00000029530
  
Biological name :Ccr9
  
Synonyms : C-C chemokine receptor type 9 / Ccr9 / Q9WUT7
  
Possible biological names infered from orthology : C-C motif chemokine receptor 9 / P51686
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F4
Gene start: 123678439
Gene end: 123784330
  
Corresponding Affymetrix probe sets: 10590620 (MoGene1.0st)   1421919_a_at (Mouse Genome 430 2.0 Array)   1421920_a_at (Mouse Genome 430 2.0 Array)   1427419_x_at (Mouse Genome 430 2.0 Array)   1436065_at (Mouse Genome 430 2.0 Array)   1442758_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127024
Ensembl peptide - ENSMUSP00000137144
Ensembl peptide - ENSMUSP00000107081
Ensembl peptide - ENSMUSP00000126758
Ensembl peptide - ENSMUSP00000131782
NCBI entrez gene - 12769     See in Manteia.
MGI - MGI:1341902
RefSeq - NM_001166625
RefSeq - NM_009913
RefSeq Peptide - NP_001160097
RefSeq Peptide - NP_034043
swissprot - Q9WUT7
swissprot - F8WIS0
Ensembl - ENSMUSG00000029530
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccr9aENSDARG00000055186Danio rerio
 ccr9bENSDARG00000099738Danio rerio
 CCR9ENSGALG00000011808Gallus gallus
 CCR9ENSG00000173585Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794440
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852136
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089933
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910333
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922733
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935532
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538232
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789831
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580431
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023230
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403930
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848030
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618030
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544830
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788029
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453429
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405228
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233628
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226227
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR004069  CC chemokine receptor 9
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002305 CD8-positive, gamma-delta intraepithelial T cell differentiation IMP
 biological_processGO:0006935 chemotaxis IDA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016493 C-C chemokine receptor activity IDA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mglltm1.1Rzim/Mglltm1.1Rzim
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ccl25tm1Mal/Ccl25tm1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ccr9tm1Ccb/Ccr9tm1Ccb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: C3tm1Crr/C3tm1Crr
Genetic Background: B6;129S4-C3tm1Crr/J

Allelic Composition: Ccr9tm1.1Mal/Ccr9tm1.1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Pmc/Atm+,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: C3tm1Crr/C3tm1Crr
Genetic Background: B6;129S4-C3tm1Crr/J

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

 MP:0008345 abnormal gamma-delta T cell number "anomaly in the number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: C3tm1Crr/C3tm1Crr
Genetic Background: B6;129S4-C3tm1Crr/J

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
Show

Allelic Composition: Atmtm1Pmc/Atm+,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0008349 abnormal gamma-delta intraepithelial T cell morphology "any structural anomaly of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
Show

Allelic Composition: Atmtm1Pmc/Atm+,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0008351 decreased gamma-delta intraepithelial T cell number "reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
Show

Allelic Composition: C3tm1Crr/C3tm1Crr
Genetic Background: B6;129S4-C3tm1Crr/J

Allelic Composition: Ccr9tm1.1Mal/Ccr9tm1.1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0008363 decreased CD8-positive, gamma-delta intraepithelial T cell number "reduced number of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000803, ISBN:0781735149]
Show

Allelic Composition: Atmtm1Pmc/Atm+,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0008399 abnormal alpha-beta intraepithelial T cell morphology "any structural anomaly of a alpha-beta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Ccr9tm1.1Mal/Ccr9tm1.1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023235 Ccl25 / O35903 / C-C motif chemokine 25 / O15444* / C-C motif chemokine ligand 25*  / reaction / complex






 

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