ENSMUSG00000023235


Mus musculus

Features
Gene ID: ENSMUSG00000023235
  
Biological name :Ccl25
  
Synonyms : Ccl25 / C-C motif chemokine 25 / O35903
  
Possible biological names infered from orthology : C-C motif chemokine ligand 25 / O15444
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 4325210
Gene end: 4360020
  
Corresponding Affymetrix probe sets: 10569958 (MoGene1.0st)   10569962 (MoGene1.0st)   1418777_at (Mouse Genome 430 2.0 Array)   1458277_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117515
Ensembl peptide - ENSMUSP00000106610
Ensembl peptide - ENSMUSP00000120719
Ensembl peptide - ENSMUSP00000140747
Ensembl peptide - ENSMUSP00000024004
Ensembl peptide - ENSMUSP00000064658
Ensembl peptide - ENSMUSP00000096548
NCBI entrez gene - 20300     See in Manteia.
MGI - MGI:1099448
RefSeq - XM_011242044
RefSeq - NM_009138
RefSeq - XM_006508736
RefSeq - XM_006508739
RefSeq - XM_011242043
RefSeq Peptide - NP_033164
swissprot - O35903
swissprot - Q3U4J3
swissprot - Q3V2F3
swissprot - D3Z470
swissprot - F7C0M8
swissprot - D3YWJ1
swissprot - A0A087WRS0
Ensembl - ENSMUSG00000023235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCL25ENSG00000131142Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001811  Chemokine interleukin-8-like domain
 IPR034133  Chemokine CC, DCCL motif-cointaining domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001954 positive regulation of cell-matrix adhesion ISO
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0006935 chemotaxis IDA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0048247 lymphocyte chemotaxis IBA
 biological_processGO:0050900 leukocyte migration IDA
 biological_processGO:0060326 cell chemotaxis ISO
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 biological_processGO:1903237 negative regulation of leukocyte tethering or rolling ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity ISO
 molecular_functionGO:0031735 CCR10 chemokine receptor binding ISO
 molecular_functionGO:0042379 chemokine receptor binding ISS
 molecular_functionGO:0048020 CCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ccl25tm1Mal/Ccl25tm1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: C3tm1Crr/C3tm1Crr
Genetic Background: B6;129S4-C3tm1Crr/J

Allelic Composition: Ccl25tm1Mal/Ccl25tm1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0005232 abnormal mesenteric lymph node morphology "anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: C3tm1Crr/C3tm1Crr
Genetic Background: B6;129S4-C3tm1Crr/J

 MP:0008345 abnormal gamma-delta T cell number "anomaly in the number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: C3tm1Crr/C3tm1Crr
Genetic Background: B6;129S4-C3tm1Crr/J

 MP:0008351 decreased gamma-delta intraepithelial T cell number "reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: C3tm1Crr/C3tm1Crr
Genetic Background: B6;129S4-C3tm1Crr/J

Allelic Composition: Ccl25tm1Mal/Ccl25tm1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0008399 abnormal alpha-beta intraepithelial T cell morphology "any structural anomaly of a alpha-beta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
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Allelic Composition: Ccl25tm1Mal/Ccl25tm1Mal,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000079355 Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*  / complex / reaction
 ENSMUSG00000029530 Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*  / reaction / complex






 

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