ENSMUSG00000079355


Mus musculus

Features
Gene ID: ENSMUSG00000079355
  
Biological name :Ackr4
  
Synonyms : Ackr4 / atypical chemokine receptor 4 / Q924I3
  
Possible biological names infered from orthology : Q9NPB9
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 104084157
Gene end: 104126933
  
Corresponding Affymetrix probe sets: 10596222 (MoGene1.0st)   1426139_a_at (Mouse Genome 430 2.0 Array)   1437668_at (Mouse Genome 430 2.0 Array)   1437669_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075507
Ensembl peptide - ENSMUSP00000140792
Ensembl peptide - ENSMUSP00000152036
NCBI entrez gene - 252837     See in Manteia.
MGI - MGI:2181676
RefSeq - XM_006511735
RefSeq - NM_145700
RefSeq - XM_006511734
RefSeq Peptide - NP_663746
swissprot - Q924I3
Ensembl - ENSMUSG00000079355
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ackr4aENSDARG00000078729Danio rerio
 ackr4bENSDARG00000040133Danio rerio
 ACKR4ENSGALG00000041491Gallus gallus
 ACKR4ENSG00000129048Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794437
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089935
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953034
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538233
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405233
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852132
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789831
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618031
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848031
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233630
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922730
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580429
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788029
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023229
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544829
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226229
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453429
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910328
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403926
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR005383  Atypical chemokine receptor 4
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity ISS
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0019956 chemokine binding IEA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

Allelic Composition: Ackr4tm1Ccbl/Ackr4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0008073 abnormal CD4-positive T cell number "anomaly in the number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0008690 increased interleukin-23 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]
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Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0010219 increased T-helper 17 cell number "increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: F9tm3Dws/Y
Genetic Background: B6.129P2-F9tm3Dws

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023235 Ccl25 / O35903 / C-C motif chemokine 25 / O15444* / C-C motif chemokine ligand 25*  / reaction / complex
 ENSMUSG00000094686 P84444 / Ccl21a / C-C motif chemokine 21a / CCL21* / O00585* / C-C motif chemokine ligand 21*  / complex / reaction
 ENSMUSG00000071005 Ccl19 / O70460 / C-C motif chemokine 19 / Q99731* / C-C motif chemokine ligand 19*  / reaction / complex
 ENSMUSG00000096596 P86792 / P86793 / Gm10591 / predicted gene 10591 / CCL21* / O00585* / C-C motif chemokine ligand 21*  / complex / reaction






 

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