ENSMUSG00000045382


Mus musculus

Features
Gene ID: ENSMUSG00000045382
  
Biological name :Cxcr4
  
Synonyms : Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA.
  
Possible biological names infered from orthology : C-X-C motif chemokine receptor 4 / P61073
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E3
Gene start: 128588199
Gene end: 128592293
  
Corresponding Affymetrix probe sets: 10357472 (MoGene1.0st)   1448710_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120153
Ensembl peptide - ENSMUSP00000053489
NCBI entrez gene - 12767     See in Manteia.
MGI - MGI:109563
RefSeq - XM_006529114
RefSeq - NM_001356509
RefSeq - NM_009911
RefSeq - XM_006529113
RefSeq Peptide - NP_001343438
RefSeq Peptide - NP_034041
swissprot - E9Q2D4
swissprot - A0A0R4J0N8
Ensembl - ENSMUSG00000045382
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcr4aENSDARG00000057633Danio rerio
 cxcr4bENSDARG00000041959Danio rerio
 CXCR4ENSGALG00000012357Gallus gallus
 CXCR4ENSG00000121966Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953033
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618032
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935532
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789832
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023232
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794431
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089931
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233630
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848030
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226230
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788030
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453429
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580429
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910328
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922728
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405228
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403927
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852127
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050926
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544826


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR001277  CXC chemokine receptor 4/atypical chemokine receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR022726  CXC chemokine receptor 4 N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0050920 regulation of chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA
 molecular_functionGO:0019955 cytokine binding IEA
 molecular_functionGO:0019957 C-C chemokine binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0032027 myosin light chain binding IEA
 molecular_functionGO:0043130 ubiquitin binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Poc1acha/Poc1acha
Genetic Background: involves: DBA/2J * M. m. castaneus

 MP:0000262 poor arterial differentiation "failure of or inadequate acquisition of the characteristics and/or functions of the arteries" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cxcr4tm1Tng/Cxcr4tm2Tng,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Poc1acha/Poc1acha
Genetic Background: involves: DBA/2J * M. m. castaneus

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Poc1acha/Poc1acha
Genetic Background: involves: DBA/2J * M. m. castaneus

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000532 kidney vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the organ of secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000533 kidney hemorrhage "bleeding in the organ of excretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Sf1Gt(XD130)Byg/Sf1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * MOLF/Ei

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0000853 absent cerebellar foliation "missing small branches of the cerebellar lobules" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

Allelic Composition: Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo
Genetic Background: Not Specified

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

 MP:0001602 impaired myelopoiesis "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

Allelic Composition: Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo
Genetic Background: Not Specified

 MP:0001603 failure of myelopoiesis "missing the process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:60896]
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Allelic Composition: Poc1acha/Poc1acha
Genetic Background: involves: DBA/2J * M. m. castaneus

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Poc1acha/Poc1acha
Genetic Background: involves: DBA/2J * M. m. castaneus

Allelic Composition: Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo
Genetic Background: Not Specified

Allelic Composition: Cxcr4tm1Tng/Cxcr4tm2Tng,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Poc1acha/Poc1acha
Genetic Background: involves: DBA/2J * M. m. castaneus

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm3.1Yzo,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnr1tm1.1Ltz/Cnr1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0002389 abnormal Peyer s patch follicle morphology "anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmo1tm2Thr/Lmo1tm2Thr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo
Genetic Background: Not Specified

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0002982 abnormal germ cell migration "defects in the orderly movement of a germ cell, a cell specialized to produce haploid gametes, from one site to another during development" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: B6.Cg-Cxcr4tm1Tng

 MP:0003090 abnormal muscle progenitor cell migration "defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hes1tm1Fgu/Hes1+,Hes5tm1Fgu/Hes5tm1Fgu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Sf1Gt(XD130)Byg/Sf1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * MOLF/Ei

 MP:0003359 hypaxial muscle hypoplasia "reduced cell number in the muscles of the limbs" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Sf1Gt(XD130)Byg/Sf1+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * MOLF/Ei

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Ccr5tm1Kuz/Ccr5tm1Kuz,Cxcr4tm1Qma/Cxcr4tm1Qma
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004017 duplex kidney "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004159 double aortic arch "defect in which the main aorta tube splits into large left and right branches (right and left aortic arches), encircling the trachea and esophagus, before becoming one tube to go to the lower body " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cnr1tm1.1Ltz/Cnr1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cxcr4tm1Tng/Cxcr4tm2Tng,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006115 aortic valve atresia "congenital closure of the aortic valve" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0008073 abnormal CD4-positive T cell number "anomaly in the number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm1Tng/Cxcr4tm2Tng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo
Genetic Background: Not Specified

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm2Yzo/Cxcr4tm2Yzo
Genetic Background: involves: 129P2/OlaHsd

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm3(Runx2)Flng/Gt(ROSA)26Sortm3(Runx2)Flng,Ihhtm1Amc/Ihhtm1Amc,Tg(Col2a1-cre)3Amc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009119 increased brown fat cell size "increase in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009298 increased mesenteric fat pad weight 
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009304 increased retroperitoneal fat pad weight 
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009577 abnormal developmental vascular remodeling "any anomaly in the process by which existing vessels are reorganized during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cxcr4tm1Tng/Cxcr4tm2Tng,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009907 decreased tongue size "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cxcr4b2b220Clo/Cxcr4b2b220Clo
Genetic Background: C57BL/6J-Cxcr4b2b220Clo

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Cxcr4b2b220Clo/Cxcr4b2b220Clo
Genetic Background: C57BL/6J-Cxcr4b2b220Clo

 MP:0010428 abnormal heart right ventricle outflow tract morphology "any structural anomaly of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

 MP:0010463 aorta stenosis "diffuse constriction or narrowing of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4b2b220Clo/Cxcr4b2b220Clo
Genetic Background: C57BL/6J-Cxcr4b2b220Clo

 MP:0010485 aortic arch hypoplasia "underdevelopment or reduced size of the aortic arch, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4b2b220Clo/Cxcr4b2b220Clo
Genetic Background: C57BL/6J-Cxcr4b2b220Clo

 MP:0010617 thick mitral valve cusps 
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

Allelic Composition: Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo
Genetic Background: Not Specified

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Chek1tm1Sje/Chek1tm1Sje
Genetic Background: Not Specified

Allelic Composition: Cxcr4tm1Tng/Cxcr4tm1Tng
Genetic Background: involves: 129P2/OlaHsd

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0011518 abnormal cell chemotaxis "any anomaly in the directed movement of a motile cell guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [GO:0060326]
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Allelic Composition: Scn4atm1.1Cann/Scn4a+
Genetic Background: involves: 129

 MP:0012568 decreased mammary gland tumor incidence in breeding females "less than the expected number of neoplams in the mammary gland in female organisms that are actively mating and producing offspring" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Trp63tm2.2Elrf/Trp63+
Genetic Background: Not Specified

 MP:0014145 increased white adipose tissue mass "increased physical bulk or volume of white adipose tissue" [MGI:csmith]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0014170 increased brown adipose tissue mass "increased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020202 abnormal macrophage cell number "an anomaly in the number of macrophages" [GOC:NV]
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Allelic Composition: Cxcr4tm2Yzo/Cxcr4tm2Yzo,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030208 abnormal intrinsic tongue muscle morphology "any structural anomaly of any of the four paired muscles that originate and insert within the tongue, running along its length; these muscles alter the shape of the tongue by lengthening and shortening it, curling and uncurling its apex and edges, and flattening and rounding its surface; they include the superior longitudinal muscle, the inferior longitudinal muscle, the vertical muscle, and the transverse muscle" [https://en.wikipedia.org/wiki/Tongue, https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Muscles-of-tongue, MGI:anna]
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Allelic Composition: Cxcr4tm1Qma/Cxcr4tm1Qma,Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022883 Robo1 / roundabout guidance receptor 1 / Q9Y6N7*  / complex / reaction
 ENSMUSG00000031558 Slit2 / Q9R1B9 / slit guidance ligand 2 / O94813*  / complex / reaction
 ENSMUSG00000061353 Cxcl12 / P40224 / Stromal cell-derived factor 1 / P48061* / C-X-C motif chemokine ligand 12*  / complex / reaction






 

1 s.

 
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