Manteia

ENSGALG00000012357

Gallus gallus

Features

Gene ID:	ENSGALG00000012357

Biological name :	CXCR4

Synonyms :	C-X-C motif chemokine receptor 4 / CXCR4

Possible biological names infered from orthology :	Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073

Species:	Gallus gallus

Chr. number:	7
Strand:	-1
Band:
Gene start:	30913614
Gene end:	30916302

Corresponding Affymetrix probe sets:	Gga.2305.1.S1_at (Chicken Array)

Cross references:	Ensembl peptide - ENSGALP00000059056 Ensembl peptide - ENSGALP00000020157 NCBI entrez gene - 395324 See in Manteia. RefSeq - NM_204617 RefSeq Peptide - NP_989948 swissprot - Q9DGI1 swissprot - A0A1L1RJW9 Ensembl - ENSGALG00000012357

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
cxcr4a	ENSDARG00000057633	Danio rerio
cxcr4b	ENSDARG00000041959	Danio rerio
CXCR4	ENSG00000121966	Homo sapiens
Cxcr4	ENSMUSG00000045382	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
CCR4 / C-C motif chemokine receptor 4 / P51679* / P51680* / C-C chemokine receptor type 4 *	ENSGALG00000039146	32
CXCR1 / CXCR2* / Q810W6* / P25024* / P25025* / P35343* / C-X-C chemokine receptor type 1 * / C-X-C motif chemokine receptor 2* / C-X-C motif chemokine receptor 1* / C-X-C chemokine receptor type 2 *	ENSGALG00000036627	31
CCR8 / C-C motif chemokine receptor 8 / P51685* / P56484* / C-C chemokine receptor type 8 *	ENSGALG00000038069	31
CXCR5 / C-X-C motif chemokine receptor 5 / P32302* / Q04683* / C-X-C chemokine receptor type 5 *	ENSGALG00000007675	30
CCR8L / C-C chemokine receptor 8 like / CCR8* / P51685* / P56484* / C-C motif chemokine receptor 8* / C-C chemokine receptor type 8 *	ENSGALG00000011734	30
CCR2 / C-C chemokine receptor type 2 / CCR1* / CCR5* / CCR3* / P51681* / P51683* / P51675* / P51676* / P51677* / P51678* / P51682* / Ccr1l1* / P32246* / P41597* / C-C motif chemokine recep...	ENSGALG00000011733	30
CCR7 / C-C motif chemokine receptor 7 / P32248* / P47774* / C-C chemokine receptor type 7 *	ENSGALG00000035733	30
CCR5 / CCR1* / CCR3* / CCR2* / P51681* / P41597* / P51675* / P51676* / P51677* / P51678* / P51682* / P51683* / Ccr1l1* / P32246* / C-C motif chemokine receptor 3* / C-C chemokine receptor t...	ENSGALG00000037077	30
CCR9 / C-C chemokine receptor type 9 / P51686* / Q9WUT7* / C-C motif chemokine receptor 9*	ENSGALG00000011808	30
ACKR4 / atypical chemokine receptor 4 / Q924I3* / Q9NPB9*	ENSGALG00000041491	29
CX3CR1 / C-X3-C motif chemokine receptor 1 / P49238* / Q9Z0D9* / CX3C chemokine receptor 1 *	ENSGALG00000038000	28
CCR6 / C-C chemokine receptor type 6 / O54689* / P51684* / C-C motif chemokine receptor 6* / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA.*	ENSGALG00000011418	28
ACKR2 / atypical chemokine receptor 2 / O00590* / O08707*	ENSGALG00000005305	27
XCR1 / X-C motif chemokine receptor 1 / P46094* / chemokine (C motif) receptor 1*	ENSGALG00000011735	25
CCR10 / C-C motif chemokine receptor 10 / P46092* / Q9JL21* / C-C chemokine receptor type 10 *	ENSGALG00000028519	25

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR000355	Chemokine receptor family
IPR001277	CXC chemokine receptor 4/atypical chemokine receptor 2
IPR017452	GPCR, rhodopsin-like, 7TM
IPR022726	CXC chemokine receptor 4 N-terminal domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001666	response to hypoxia	IEA
biological_process	GO:0006935	chemotaxis	IEA
biological_process	GO:0007154	cell communication	IMP
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0014812	muscle cell migration	IMP
biological_process	GO:0019722	calcium-mediated signaling	IEA
biological_process	GO:0050920	regulation of chemotaxis	IEA
biological_process	GO:0070098	chemokine-mediated signaling pathway	IEA
biological_process	GO:0071345	cellular response to cytokine stimulus	IEA
biological_process	GO:1901863	positive regulation of muscle tissue development	IMP
biological_process	GO:1990869	cellular response to chemokine	IMP
cellular_component	GO:0005764	lysosome	IEA
cellular_component	GO:0005769	early endosome	IEA
cellular_component	GO:0005770	late endosome	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0009986	cell surface	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0031252	cell leading edge	IEA
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
cellular_component	GO:0032991	protein-containing complex	IEA
molecular_function	GO:0003779	actin binding	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0004950	chemokine receptor activity	IEA
molecular_function	GO:0019955	cytokine binding	IEA
molecular_function	GO:0019957	C-C chemokine binding	IEA
molecular_function	GO:0031625	ubiquitin protein ligase binding	IEA
molecular_function	GO:0032027	myosin light chain binding	IEA
molecular_function	GO:0043130	ubiquitin binding	IEA

Pathways (from Reactome)

Pathway description

Signaling by ROBO receptors

Chemokine receptors bind chemokines

G alpha (i) signalling events

Phenotype (from MGI, Zfin or HPO)

Phenotype

Definition

Genetic BG

No match

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSGALG00000041346	CXCL12 / C-X-C motif chemokine ligand 12 / P40224* / P48061* / Stromal cell-derived factor 1 *	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr