ENSDARG00000057633


Danio rerio

Features
Gene ID: ENSDARG00000057633
  
Biological name :cxcr4a
  
Synonyms : chemokine (C-X-C motif) receptor 4a / cxcr4a
  
Possible biological names infered from orthology : C-X-C motif chemokine receptor 4 / CXCR4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 12922002
Gene end: 12923727
  
Corresponding Affymetrix probe sets: Dr.15055.1.S1_at (Zebrafish Array)   NM_131882_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000123851
Ensembl peptide - ENSDARP00000074800
NCBI entrez gene - 140747     See in Manteia.
RefSeq - NM_131882
RefSeq Peptide - NP_571957
swissprot - F8W4X7
swissprot - F1QCB2
ZFIN ID - ZDB-GENE-020102-1
Ensembl - ENSDARG00000057633
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CXCR4ENSGALG00000012357Gallus gallus
 CXCR4ENSG00000121966Homo sapiens
 Cxcr4ENSMUSG00000045382Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cxcr4b / chemokine (C-X-C motif), receptor 4b / CXCR4* / P61073* / C-X-C motif chemokine receptor 4* / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA.*ENSDARG0000004195973
E9QJ73 / cxcr3.2 / chemokine (C-X-C motif) receptor 3, tandem duplicate 2ENSDARG0000004104132
cxcr3.1 / chemokine (C-X-C motif) receptor 3, tandem duplicate 1 / CXCR3* / O88410* / P49682* / C-X-C motif chemokine receptor 3* / C-X-C chemokine receptor type 3 *ENSDARG0000000735832
cabz01093075.1 / CCR8* / P51685* / C-C motif chemokine receptor 8*ENSDARG0000008661631
ccr9b / chemokine (C-C motif) receptor 9b / CCR9* / Q9WUT7* / P51686* / C-C chemokine receptor type 9 * / C-C motif chemokine receptor 9*ENSDARG0000009973831
cxcr5 / chemokine (C-X-C motif) receptor 5 / P32302* / C-X-C motif chemokine receptor 5*ENSDARG0000001051431
ccr6a / chemokine (C-C motif) receptor 6a / CCR6* / P51684* / O54689* / C-C motif chemokine receptor 6* / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA.*ENSDARG0000008747431
ccr9a / chemokine (C-C motif) receptor 9a / CCR9* / Q9WUT7* / P51686* / C-C chemokine receptor type 9 * / C-C motif chemokine receptor 9*ENSDARG0000005518630
ackr4a / atypical chemokine receptor 4a / ACKR4* / Q924I3* / Q9NPB9* / atypical chemokine receptor 4*ENSDARG0000007872930
ccr8.1 / chemokine (C-C motif) receptor 8.1 / CCR8* / P56484* / P51685* / C-C chemokine receptor type 8 * / C-C motif chemokine receptor 8*ENSDARG0000009578930
cxcr2 / chemokine (C-X-C motif) receptor 2 / CXCR1* / P25024* / P25025* / P35343* / Q810W6* / C-X-C chemokine receptor type 1 * / C-X-C motif chemokine receptor 2* / C-X-C chemokine recepto...ENSDARG0000005497530
ackr4b / atypical chemokine receptor 4b / ACKR4* / Q924I3* / Q9NPB9* / atypical chemokine receptor 4*ENSDARG0000004013329
ccr2 / si:ch211-207g17.3 / CCR5* / CCR1* / CCR3* / CCR4* / P51675* / P51676* / P51677* / P51678* / P51679* / P51682* / P51681* / P51683* / P51680* / Ccr1l1* / P32246* / P41597* / C-C motif ...ENSDARG0000010536329
ccr7 / chemokine (C-C motif) receptor 7 / P32248* / P47774* / C-C chemokine receptor type 7 * / C-C motif chemokine receptor 7*ENSDARG0000004456129
ccr6b / chemokine (C-C motif) receptor 6b / CCR6* / P51684* / O54689* / C-C motif chemokine receptor 6* / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA.*ENSDARG0000003896828
si:ch73-54b5.2ENSDARG0000005208828
ccr2 / chemokine (C-C motif) receptor 2 / CCR3* / CCR5* / CCR1* / CCR4* / P51681* / P41597* / P51675* / P51676* / P51677* / P51678* / P51679* / P51680* / P51682* / P51683* / Ccr1l1* / P3224...ENSDARG0000007982928
ccr12a / chemokine (C-C motif) receptor 12aENSDARG0000003854127
ccr12b.1 / chemokine (C-C motif) receptor 12b, tandem duplicate 1ENSDARG0000005941026
si:cabz01093077.1 / CCR8* / P51685* / C-C motif chemokine receptor 8*ENSDARG0000010546726


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR001277  CXC chemokine receptor 4/atypical chemokine receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0002042 cell migration involved in sprouting angiogenesis IMP
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IGI
 biological_processGO:0055002 striated muscle cell development IMP
 biological_processGO:0060231 mesenchymal to epithelial transition IMP
 biological_processGO:0061053 somite development IMP
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:1903045 neural crest cell migration involved in sympathetic nervous system development IGI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000017 endoderm endoderm mislocalised anteriorly , abnormal
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 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
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 ZFA:0000112 gut gut morphology , abnormal
gut bifurcated , abnormal
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 ZFA:0000123 liver liver decreased size , abnormal
liver duplicated , abnormal
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 ZFA:0000140 pancreas pancreas morphology , abnormal
pancreas decreased size , abnormal
pancreas pancreatic B cell dispersed , abnormal
pancreas duplicated , abnormal
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 ZFA:0000155 somite somite morphology , abnormal
somite cellular quality , abnormal
somite increased amount , abnormal
somite increased distribution , abnormal
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 ZFA:0001052 primordial hindbrain channel primordial hindbrain channel angiogenic sprout mislocalised , abnormal
primordial hindbrain channel angiogenic sprout decreased amount , abnormal
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 ZFA:0001054 lateral dorsal aorta lateral dorsal aorta malformed , abnormal
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 ZFA:0001194 cranial neural crest cranial neural crest filopodium decreased length , abnormal
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 ZFA:0001260 endocrine pancreas endocrine pancreas mislocalised , abnormal
endocrine pancreas malformed , abnormal
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 ZFA:0001269 regenerating fin regenerating fin blood vessel endothelial cell migration disrupted , abnormal
regenerating fin caudal fin lacks parts or has fewer parts of type artery , abnormal
regenerating fin caudal fin vasculature decreased length , abnormal
regenerating fin caudal fin vasculature decreased area , abnormal
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 ZFA:0001338 intestine intestine duplicated , abnormal
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 ZFA:0001462 somite border somite border morphology , abnormal
somite border malformed , abnormal
somite border centrosome spatial pattern , abnormal
somite border mesenchymal to epithelial transition decreased occurrence , abnormal
somite border epithelial cell morphology , abnormal
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 ZFA:0005002 basilar artery basilar artery unlumenized , abnormal
basilar artery agenesis , abnormal
basilar artery absent , abnormal
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 ZFA:0005020 central artery central artery malformed , abnormal
central artery physical object quality , abnormal
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 ZFA:0005110 thoracic duct thoracic duct lymphangiogenesis decreased process quality , abnormal
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 ZFA:0009036 blood vessel endothelial cell blood vessel endothelial cell mislocalised , abnormal
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 ZFA:0009139 endodermal cell endodermal cell circular , abnormal
endodermal cell filopodium orientation whole organism dorsal-ventral axis, abnormal
endodermal cell filopodium decreased amount , abnormal
endodermal cell mislocalised anteriorly , abnormal
endodermal cell displaced to margin , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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