ENSDARG00000041959


Danio rerio

Features
Gene ID: ENSDARG00000041959
  
Biological name :cxcr4b
  
Synonyms : chemokine (C-X-C motif), receptor 4b / cxcr4b
  
Possible biological names infered from orthology : C-X-C motif chemokine receptor 4 / CXCR4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 10692905
Gene end: 10694930
  
Corresponding Affymetrix probe sets: Dr.6798.1.S1_at (Zebrafish Array)   NM_131834_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000061498
NCBI entrez gene - 114447     See in Manteia.
RefSeq - NM_131834
RefSeq Peptide - NP_571909
swissprot - Q9PTF7
ZFIN ID - ZDB-GENE-010614-1
Ensembl - ENSDARG00000041959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CXCR4ENSGALG00000012357Gallus gallus
 CXCR4ENSG00000121966Homo sapiens
 Cxcr4ENSMUSG00000045382Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cxcr4a / chemokine (C-X-C motif) receptor 4a / CXCR4* / P61073* / C-X-C motif chemokine receptor 4* / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA.*ENSDARG0000005763374
cxcr3.1 / chemokine (C-X-C motif) receptor 3, tandem duplicate 1 / CXCR3* / O88410* / P49682* / C-X-C motif chemokine receptor 3* / C-X-C chemokine receptor type 3 *ENSDARG0000000735833
ccr9a / chemokine (C-C motif) receptor 9a / CCR9* / Q9WUT7* / P51686* / C-C chemokine receptor type 9 * / C-C motif chemokine receptor 9*ENSDARG0000005518631
ackr4a / atypical chemokine receptor 4a / ACKR4* / Q924I3* / Q9NPB9* / atypical chemokine receptor 4*ENSDARG0000007872931
ccr9b / chemokine (C-C motif) receptor 9b / CCR9* / Q9WUT7* / P51686* / C-C chemokine receptor type 9 * / C-C motif chemokine receptor 9*ENSDARG0000009973831
E9QJ73 / cxcr3.2 / chemokine (C-X-C motif) receptor 3, tandem duplicate 2ENSDARG0000004104131
cxcr5 / chemokine (C-X-C motif) receptor 5 / P32302* / C-X-C motif chemokine receptor 5*ENSDARG0000001051431
ccr6a / chemokine (C-C motif) receptor 6a / CCR6* / P51684* / O54689* / C-C motif chemokine receptor 6* / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA.*ENSDARG0000008747430
cabz01093075.1 / CCR8* / P51685* / C-C motif chemokine receptor 8*ENSDARG0000008661629
ccr8.1 / chemokine (C-C motif) receptor 8.1 / CCR8* / P56484* / P51685* / C-C chemokine receptor type 8 * / C-C motif chemokine receptor 8*ENSDARG0000009578929
ccr2 / si:ch211-207g17.3 / CCR5* / CCR1* / CCR3* / CCR4* / P51675* / P51676* / P51677* / P51678* / P51679* / P51682* / P51681* / P51683* / P51680* / Ccr1l1* / P32246* / P41597* / C-C motif ...ENSDARG0000010536329
ackr4b / atypical chemokine receptor 4b / ACKR4* / Q924I3* / Q9NPB9* / atypical chemokine receptor 4*ENSDARG0000004013329
ccr6b / chemokine (C-C motif) receptor 6b / CCR6* / P51684* / O54689* / C-C motif chemokine receptor 6* / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA.*ENSDARG0000003896828
ccr7 / chemokine (C-C motif) receptor 7 / P32248* / P47774* / C-C chemokine receptor type 7 * / C-C motif chemokine receptor 7*ENSDARG0000004456128
ccr12a / chemokine (C-C motif) receptor 12aENSDARG0000003854128
ccr2 / chemokine (C-C motif) receptor 2 / CCR3* / CCR5* / CCR1* / CCR4* / P51681* / P41597* / P51675* / P51676* / P51677* / P51678* / P51679* / P51680* / P51682* / P51683* / Ccr1l1* / P3224...ENSDARG0000007982927
cxcr2 / chemokine (C-X-C motif) receptor 2 / CXCR1* / P25024* / P25025* / P35343* / Q810W6* / C-X-C chemokine receptor type 1 * / C-X-C motif chemokine receptor 2* / C-X-C chemokine recepto...ENSDARG0000005497527
si:ch73-54b5.2ENSDARG0000005208827
ccr11.1 / chemokine (C-C motif) receptor 11.1 / CCR3* / CCR2* / CCR4* / CCR5* / CCR1* / P51681* / P51683* / P41597* / P51675* / P51676* / P51677* / P51678* / P51679* / P51680* / P51682* / C...ENSDARG0000007075526
xcr1b.1 / chemokine (C motif) receptor 1b, duplicate 1 / XCR1* / P46094* / X-C motif chemokine receptor 1*ENSDARG0000005298825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR001277  CXC chemokine receptor 4/atypical chemokine receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001667 ameboidal-type cell migration IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007281 germ cell development IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0008354 germ cell migration IMP
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0021730 trigeminal sensory nucleus development IMP
 biological_processGO:0030516 regulation of axon extension IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IGI
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0042246 tissue regeneration IEP
 biological_processGO:0048920 posterior lateral line neuromast primordium migration IMP
 biological_processGO:0050918 positive chemotaxis IMP
 biological_processGO:0050930 induction of positive chemotaxis IMP
 biological_processGO:0051453 regulation of intracellular pH IMP
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0090022 regulation of neutrophil chemotaxis IMP
 biological_processGO:0090024 negative regulation of neutrophil chemotaxis IMP
 biological_processGO:0106014 regulation of inflammatory response to wounding IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001637 G-protein coupled chemoattractant receptor activity IMP
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta circulating cell has extra parts of type neutrophil , abnormal
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 ZFA:0000037 anatomical structure anatomical structure amount , ameliorated
anatomical structure increased amount , abnormal
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 ZFA:0000155 somite somite cellular quality , abnormal
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 ZFA:0000295 trigeminal ganglion trigeminal ganglion axon position , abnormal
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 ZFA:0000405 cranial nerve III cranial nerve III mislocalised , abnormal
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 ZFA:0000529 kidney kidney neutrophil decreased amount , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
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 ZFA:0001058 caudal fin caudal fin neutrophil increased amount , abnormal
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 ZFA:0001157 posterior lateral line primordium posterior lateral line primordium physical object quality , abnormal
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 ZFA:0001269 regenerating fin regenerating fin neutrophil increased amount , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel angiogenic sprout decreased amount , abnormal
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 ZFA:0005024 trunk vasculature trunk vasculature morphology , ameliorated
trunk vasculature response to bacterium process quality , abnormal
trunk vasculature response to bacterium process quality , exacerbated
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 ZFA:0005768 trigeminal sensory neuron trigeminal sensory neuron mislocalised , abnormal
trigeminal sensory neuron cell migration process quality , abnormal
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 ZFA:0009125 olfactory receptor cell olfactory receptor cell mislocalised ventrally , abnormal
olfactory receptor cell mislocalised medially , abnormal
olfactory receptor cell mislocalised , abnormal
olfactory receptor cell axon misrouted , abnormal
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 ZFA:0009288 primordial germ cell primordial germ cell mislocalised , abnormal
primordial germ cell quality , abnormal
primordial germ cell establishment of cell polarity decreased occurrence , abnormal
primordial germ cell regulation of intracellular pH process quality , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037116 cxcl12a / chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) / CXCL12* / P40224* / P48061* / Stromal cell-derived factor 1 * / C-X-C motif chemokine ligand 12*  / complex / reaction
 ENSDARG00000055100 cxcl12b / chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) / CXCL12* / P40224* / P48061* / Stromal cell-derived factor 1 * / C-X-C motif chemokine ligand 12*  / complex / reaction
 ENSDARG00000004246 slit2 / slit homolog 2 (Drosophila) / O94813* / Q9R1B9* / slit guidance ligand 2*  / reaction / complex






 

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