Manteia

ENSDARG00000037116

Danio rerio

Features

Gene ID:	ENSDARG00000037116

Biological name :	cxcl12a

Synonyms :	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) / cxcl12a

Possible biological names infered from orthology :	CXCL12 / C-X-C motif chemokine ligand 12 / P40224 / P48061 / Stromal cell-derived factor 1

Species:	Danio rerio

Chr. number:	13
Strand:	1
Band:
Gene start:	30804367
Gene end:	30819715

Corresponding Affymetrix probe sets:	Dr.822.1.S2_at (Zebrafish Array) Dr.822.1.S3_at (Zebrafish Array)

Cross references:	Ensembl peptide - ENSDARP00000053945 NCBI entrez gene - 352944 See in Manteia. swissprot - Q8AV10 ZFIN ID - ZDB-GENE-030318-1 Ensembl - ENSDARG00000037116

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
CXCL12	ENSGALG00000041346	Gallus gallus
CXCL12	ENSG00000107562	Homo sapiens
Cxcl12	ENSMUSG00000061353	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
cxcl12b / chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) / CXCL12* / P40224* / P48061* / Stromal cell-derived factor 1 * / C-X-C motif chemokine ligand 12*	ENSDARG00000055100	73

Protein motifs (from Interpro)

Interpro ID	Name
IPR001811	Chemokine interleukin-8-like domain
IPR033899	CXC Chemokine domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000902	cell morphogenesis	IGI
biological_process	GO:0001764	neuron migration	IMP
biological_process	GO:0001946	lymphangiogenesis	IMP
biological_process	GO:0006935	chemotaxis	IMP
biological_process	GO:0006952	defense response	IEA
biological_process	GO:0006955	immune response	IEA
biological_process	GO:0007411	axon guidance	IMP
biological_process	GO:0008285	negative regulation of cell proliferation	IDA
biological_process	GO:0008354	germ cell migration	IMP
biological_process	GO:0009887	animal organ morphogenesis	IMP
biological_process	GO:0021730	trigeminal sensory nucleus development	IGI
biological_process	GO:0030239	myofibril assembly	IMP
biological_process	GO:0030335	positive regulation of cell migration	IMP
biological_process	GO:0030516	regulation of axon extension	IMP
biological_process	GO:0030900	forebrain development	IMP
biological_process	GO:0031101	fin regeneration	IMP
biological_process	GO:0031290	retinal ganglion cell axon guidance	IGI
biological_process	GO:0035701	hematopoietic stem cell migration	IGI
biological_process	GO:0042074	cell migration involved in gastrulation	IMP
biological_process	GO:0048842	positive regulation of axon extension involved in axon guidance	IDA
biological_process	GO:0048920	posterior lateral line neuromast primordium migration	IMP
biological_process	GO:0050918	positive chemotaxis	IEA
biological_process	GO:0050930	induction of positive chemotaxis	IMP
biological_process	GO:0051453	regulation of intracellular pH	IGI
biological_process	GO:0055002	striated muscle cell development	IMP
biological_process	GO:0060326	cell chemotaxis	IEA
biological_process	GO:0070098	chemokine-mediated signaling pathway	IBA
biological_process	GO:0090022	regulation of neutrophil chemotaxis	IMP
biological_process	GO:0090024	negative regulation of neutrophil chemotaxis	IGI
biological_process	GO:0097535	lymphoid lineage cell migration into thymus	IGI
biological_process	GO:0106014	regulation of inflammatory response to wounding	IMP
biological_process	GO:2000472	negative regulation of hematopoietic stem cell migration	IGI
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0009897	external side of plasma membrane	IBA
molecular_function	GO:0008009	chemokine activity	IBA
molecular_function	GO:0042056	chemoattractant activity	IMP
molecular_function	GO:0045236	CXCR chemokine receptor binding	IBA

Pathways (from Reactome)

Pathway description

Signaling by ROBO receptors

Chemokine receptors bind chemokines

G alpha (i) signalling events

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
ZFA:0000014	dorsal aorta	dorsal aorta circulating cell has extra parts of type neutrophil , abnormal	Show
ZFA:0000155	somite	somite cellular quality , abnormal somite morphology , abnormal	Show
ZFA:0000175	posterior lateral line nerve	posterior lateral line nerve axon mislocalised , abnormal	Show
ZFA:0000243	neuromast	neuromast decreased amount , abnormal	Show
ZFA:0000295	trigeminal ganglion	trigeminal ganglion axon position , abnormal	Show
ZFA:0000405	cranial nerve III	cranial nerve III mislocalised , abnormal	Show
ZFA:0000529	kidney	kidney neutrophil decreased amount , abnormal	Show
ZFA:0000563	pectoral fin musculature	pectoral fin musculature aplastic , abnormal	Show
ZFA:0000944	posterior lateral line	posterior lateral line neuromast decreased amount , abnormal	Show
ZFA:0001056	myotome	myotome cellular quality , abnormal	Show
ZFA:0001058	caudal fin	caudal fin neutrophil increased amount , abnormal	Show
ZFA:0001085	hypaxial myotome region	hypaxial myotome region aplastic , abnormal	Show
ZFA:0001157	posterior lateral line primordium	posterior lateral line primordium physical object quality , abnormal	Show
ZFA:0001269	regenerating fin	regenerating fin decreased length , abnormal regenerating fin neutrophil increased amount , abnormal regenerating fin blood vessel endothelial cell migration disrupted , abnormal regenerating fin caudal fin vasculature decreased length , abnormal regenerating fin caudal fin vasculature decreased area , abnormal	Show
ZFA:0001463	melanophore stripe	melanophore stripe melanocyte decreased amount , abnormal	Show
ZFA:0005023	hematopoietic system	hematopoietic system posterior region amount , ameliorated hematopoietic system posterior region has number of hematopoietic multipotent progenitor cell , ameliorated hematopoietic system vasculature amount , ameliorated hematopoietic system vasculature increased amount , abnormal	Show
ZFA:0005110	thoracic duct	thoracic duct lymphangiogenesis decreased process quality , abnormal	Show
ZFA:0009125	olfactory receptor cell	olfactory receptor cell mislocalised ventrally , abnormal olfactory receptor cell mislocalised medially , abnormal	Show
ZFA:0009288	primordial germ cell	primordial germ cell mislocalised , abnormal	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSDARG00000004246	slit2 / slit homolog 2 (Drosophila) / O94813* / Q9R1B9* / slit guidance ligand 2*	/ reaction / complex
ENSDARG00000062478	ackr3a / atypical chemokine receptor 3a / ACKR3* / P25106* / P56485* / atypical chemokine receptor 3*	/ complex / reaction
ENSDARG00000058179	ackr3b / atypical chemokine receptor 3b / ACKR3* / P25106* / P56485* / atypical chemokine receptor 3*	/ reaction / complex
ENSDARG00000041959	cxcr4b / chemokine (C-X-C motif), receptor 4b / CXCR4* / P61073* / C-X-C motif chemokine receptor 4* / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA.*	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr