ENSG00000107562


Homo sapiens

Features
Gene ID: ENSG00000107562
  
Biological name :CXCL12
  
Synonyms : CXCL12 / C-X-C motif chemokine ligand 12 / P48061
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q11.21
Gene start: 44370165
Gene end: 44386493
  
Corresponding Affymetrix probe sets: 203666_at (Human Genome U133 Plus 2.0 Array)   209687_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379141
Ensembl peptide - ENSP00000379139
Ensembl peptide - ENSP00000379140
Ensembl peptide - ENSP00000339913
Ensembl peptide - ENSP00000363548
Ensembl peptide - ENSP00000363551
NCBI entrez gene - 6387     See in Manteia.
OMIM - 600835
RefSeq - NM_001033886
RefSeq - NM_000609
RefSeq - NM_001178134
RefSeq - NM_001277990
RefSeq - NM_199168
RefSeq Peptide - NP_000600
RefSeq Peptide - NP_001029058
RefSeq Peptide - NP_001171605
RefSeq Peptide - NP_001264919
RefSeq Peptide - NP_954637
swissprot - P48061
Ensembl - ENSG00000107562
  
Related genetic diseases (OMIM): 609423 - {AIDS, resistance to}, 609423
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcl12aENSDARG00000037116Danio rerio
 cxcl12bENSDARG00000055100Danio rerio
 CXCL12ENSGALG00000041346Gallus gallus
 Cxcl12ENSMUSG00000061353Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001811  Chemokine interleukin-8-like domain
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0006874 cellular calcium ion homeostasis TAS
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008015 blood circulation TAS
 biological_processGO:0008064 regulation of actin polymerization or depolymerization TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009615 response to virus TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0022029 telencephalon cell migration IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0033603 positive regulation of dopamine secretion IEA
 biological_processGO:0033622 integrin activation IDA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045785 positive regulation of cell adhesion IDA
 biological_processGO:0048842 positive regulation of axon extension involved in axon guidance IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0050966 detection of mechanical stimulus involved in sensory perception of pain IEA
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0060326 cell chemotaxis IDA
 biological_processGO:0070098 chemokine-mediated signaling pathway IDA
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IDA
 biological_processGO:0090280 positive regulation of calcium ion import TAS
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IDA
 biological_processGO:1903237 negative regulation of leukocyte tethering or rolling IDA
 biological_processGO:1990478 response to ultrasound IEA
 biological_processGO:2000406 positive regulation of T cell migration IDA
 biological_processGO:2000669 negative regulation of dendritic cell apoptotic process IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0008009 chemokine activity TAS
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042056 chemoattractant activity IBA
 molecular_functionGO:0042379 chemokine receptor binding IMP
 molecular_functionGO:0045236 CXCR chemokine receptor binding IDA


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
Signaling by ROBO receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121966 CXCR4 / P61073 / C-X-C motif chemokine receptor 4  / reaction / complex
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / complex / reaction
 ENSG00000145147 SLIT2 / O94813 / slit guidance ligand 2  / reaction / complex
 ENSG00000144476 ACKR3 / P25106 / atypical chemokine receptor 3  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr