ENSMUSG00000061353


Mus musculus

Features
Gene ID: ENSMUSG00000061353
  
Biological name :Cxcl12
  
Synonyms : Cxcl12 / P40224 / Stromal cell-derived factor 1
  
Possible biological names infered from orthology : C-X-C motif chemokine ligand 12 / P48061
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F1
Gene start: 117168535
Gene end: 117181367
  
Corresponding Affymetrix probe sets: 10541075 (MoGene1.0st)   1417574_at (Mouse Genome 430 2.0 Array)   1439084_at (Mouse Genome 430 2.0 Array)   1448823_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072800
Ensembl peptide - ENSMUSP00000108487
Ensembl peptide - ENSMUSP00000108492
NCBI entrez gene - 20315     See in Manteia.
MGI - MGI:103556
RefSeq - NM_001012477
RefSeq - NM_013655
RefSeq - NM_021704
RefSeq Peptide - NP_001012495
RefSeq Peptide - NP_038683
RefSeq Peptide - NP_068350
swissprot - P40224
swissprot - H7BX38
Ensembl - ENSMUSG00000061353
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcl12aENSDARG00000037116Danio rerio
 cxcl12bENSDARG00000055100Danio rerio
 CXCL12ENSGALG00000041346Gallus gallus
 CXCL12ENSG00000107562Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001811  Chemokine interleukin-8-like domain
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001667 ameboidal-type cell migration IMP
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007281 germ cell development IDA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008045 motor neuron axon guidance IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0008354 germ cell migration IDA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0022029 telencephalon cell migration IEA
 biological_processGO:0030334 regulation of cell migration IGI
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0033603 positive regulation of dopamine secretion IEA
 biological_processGO:0033622 integrin activation IEA
 biological_processGO:0042098 T cell proliferation IMP
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0048842 positive regulation of axon extension involved in axon guidance IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0050930 induction of positive chemotaxis IDA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0050966 detection of mechanical stimulus involved in sensory perception of pain IEA
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0071542 dopaminergic neuron differentiation IDA
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IEA
 biological_processGO:0090280 positive regulation of calcium ion import IDA
 biological_processGO:0098609 cell-cell adhesion IDA
 biological_processGO:1901741 positive regulation of myoblast fusion IMP
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:1903237 negative regulation of leukocyte tethering or rolling IEA
 biological_processGO:1990478 response to ultrasound IEA
 biological_processGO:2000406 positive regulation of T cell migration IEA
 biological_processGO:2000669 negative regulation of dendritic cell apoptotic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0008009 chemokine activity IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0042056 chemoattractant activity IBA
 molecular_functionGO:0042379 chemokine receptor binding IEA
 molecular_functionGO:0045236 CXCR chemokine receptor binding IEA


Pathways (from Reactome)
Pathway description
Signaling by ROBO receptors
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcl12tm1.1Ystz/Cxcl12tm1.2Ystz,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Ndor1Tg(UBC-cre/ERT2)1Ejb/?
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0000262 poor arterial differentiation "failure of or inadequate acquisition of the characteristics and/or functions of the arteries" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+
Genetic Background: B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL/J

Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Ndor1Tg(UBC-cre/ERT2)1Ejb/?
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Tg(Col1a1-cre)2Bek/?
Genetic Background: involves: C57BL/6 * CD-1

Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sav1tm1.1Dupa/Sav1tm1.1Dupa,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Cxcl12tm1.1Ystz/Cxcl12tm1.2Ystz,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0001602 impaired myelopoiesis "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+
Genetic Background: B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sav1tm1.1Dupa/Sav1tm1.1Dupa,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: C57BL/6 * SJL/J

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sav1tm1.1Dupa/Sav1tm1.1Dupa,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Leprtm2(cre)Rck/Lepr+
Genetic Background: involves: C57BL/6

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+
Genetic Background: B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N

 MP:0002982 abnormal germ cell migration "defects in the orderly movement of a germ cell, a cell specialized to produce haploid gametes, from one site to another during development" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ntrk2tm2Kln/Ntrk2tm2Kln,Tg(Cck-cre,-lacZ)1Mini/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+
Genetic Background: B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+
Genetic Background: B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcl12tm1.1Ystz/Cxcl12tm1.2Ystz,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+
Genetic Background: B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng

Allelic Composition: Cxcl12tm1.1Ystz/Cxcl12tm1.2Ystz,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL/J

Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Ndor1Tg(UBC-cre/ERT2)1Ejb/?
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Ndor1Tg(UBC-cre/ERT2)1Ejb/?
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sh3gl1tm1Pdc/Sh3gl1tm1Pdc,Sh3gl2tm1Pdc/Sh3gl2+,Sh3gl3tm1.2Itl/Sh3gl3tm1.2Itl
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6J * FVB/N * SJL

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL/J

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+
Genetic Background: B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng

Allelic Composition: Cxcl12tm1.1Ystz/Cxcl12tm1.2Ystz,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0008249 abnormal common lymphocyte progenitor cell morphology "any structural anomaly of a progenitor cell committed to the lymphoid lineage" [CL:0000051, PMID:10407577]
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Allelic Composition: Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+
Genetic Background: B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL/J

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+
Genetic Background: B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+
Genetic Background: B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL/J

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcl12tm3.1(HBEGF/EGFP)Tng/Cxcl12+
Genetic Background: B6.Cg-Cxcl12tm3.1(HBEGF/EGFP)Tng

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL/J

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Tg(Col1a1-cre)2Bek/?
Genetic Background: involves: C57BL/6 * CD-1

 MP:0009577 abnormal developmental vascular remodeling "any anomaly in the process by which existing vessels are reorganized during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cxcl12tm1.1Ystz/Cxcl12tm1.2Ystz,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,X/Yaa
Genetic Background: B6.Cg-Fcgr2btm1Ttk Yaa

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Coq6tm1b(EUCOMM)Hmgu/Coq6+
Genetic Background: C57BL/6N-Coq6tm1b(EUCOMM)Hmgu/J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nf1tm1Tyj/Nf1tm1Tyj,Rasa1tm1Paw/Rasa1tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0011816 decreased pre-pro B cell number "reduced number of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive" [CL:0002045, MGI:csmith]
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Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N

Allelic Composition: Cxcl12tm1Tng/Cxcl12tm1.1Link,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022883 Robo1 / roundabout guidance receptor 1 / Q9Y6N7*  / reaction / complex
 ENSMUSG00000031558 Slit2 / Q9R1B9 / slit guidance ligand 2 / O94813*  / reaction / complex
 ENSMUSG00000045382 Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*  / complex / reaction
 ENSMUSG00000044337 Ackr3 / P56485 / atypical chemokine receptor 3 / P25106*  / reaction / complex






 

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