MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)
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MP:0000273 | overriding aorta | "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826] |
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)
Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
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MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Daglatm1.1Kano/Daglatm1.1Kano Genetic Background: involves: C57BL/6 * C57BL/6N * CBA
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MP:0000275 | heart hyperplasia | "increased cell number in the heart" [J:18048] |
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Allelic Composition: Ackr3tm1Jgo/Ackr3tm1Jgo Genetic Background: involves: 129S/SvEvBrd * C57BL/6
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MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
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MP:0000281 | abnormal ventricular septum morphology | "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Mcoln3Va-J/Mcoln3+ Genetic Background: B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
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MP:0000297 | abnormal endocardial cushion morphology | "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Daglatm1.1Kano/Daglatm1.1Kano Genetic Background: involves: C57BL/6 * C57BL/6N * CBA
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MP:0001544 | abnormal cardiovascular system physiology | "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Daglatm1.1Kano/Daglatm1.1Kano Genetic Background: involves: C57BL/6 * C57BL/6N * CBA
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MP:0001575 | cyanosis | "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159] |
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Allelic Composition: Daglatm1.1Kano/Daglatm1.1Kano Genetic Background: involves: C57BL/6 * C57BL/6N * CBA
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MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cul4btm1.1Pz/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+ Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA
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MP:0001625 | cardiac hypertrophy | "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
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MP:0001855 | atrial thrombosis | "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle Genetic Background: involves: 129P2/OlaHsd
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MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Ackr3tm1Jgo/Ackr3tm1Jgo Genetic Background: involves: 129S/SvEvBrd * C57BL/6
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MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Daglatm1.1Kano/Daglatm1.1Kano Genetic Background: involves: C57BL/6 * C57BL/6N * CBA
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MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Daglatm1.1Kano/Daglatm1.1Kano Genetic Background: involves: C57BL/6 * C57BL/6N * CBA
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)
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MP:0002625 | left ventricle hypertrophy | "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
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MP:0002746 | abnormal semilunar valve morphology | "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728] |
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Allelic Composition: Mcoln3Va-J/Mcoln3+ Genetic Background: B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
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MP:0002747 | abnormal aortic valve morphology | "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)
Allelic Composition: Ackr3tm1.1Fma/Ackr3+ Genetic Background: involves: BALB/cJ * C57BL/6
Allelic Composition: Ackr3tm1Fma/Ackr3tm1Fma,Tg(Tek-cre)12Flv/? Genetic Background: involves: C3H * C57BL/6
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MP:0002748 | abnormal pulmonary valve morphology | "malformation of the valve between the right ventricle and the pulmonary trunk" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)
Allelic Composition: Ackr3tm1Fma/Ackr3tm1Fma,Tg(Tek-cre)12Flv/? Genetic Background: involves: C3H * C57BL/6
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MP:0002754 | dilated right ventricle | "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)
Allelic Composition: Ackr3tm1Fma/Ackr3tm1Fma,Tg(Tek-cre)12Flv/? Genetic Background: involves: C3H * C57BL/6
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MP:0003140 | dilated atria | "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
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MP:0003141 | cardiac fibrosis | "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Ackr3tm1Jgo/Ackr3tm1Jgo Genetic Background: involves: 129S/SvEvBrd * C57BL/6
Allelic Composition: Ackr3tm1Twb/Ackr3tm1.1Twb,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6
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MP:0004564 | enlarged myocardial fiber | "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ackr3tm1Twb/Ackr3tm1.1Twb,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6
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MP:0004566 | myocardial fiber degeneration | "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Ackr3tm1Jgo/Ackr3tm1Jgo Genetic Background: involves: 129S/SvEvBrd * C57BL/6
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MP:0006050 | pulmonary fibrosis | "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Tcf7tm1Cle/Tcf7tm1Cle Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Ackr3tm1Jgo/Ackr3tm1Jgo Genetic Background: involves: 129S/SvEvBrd * C57BL/6
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MP:0006116 | aortic valve calcification | "pathologic deposition of calcium salts in the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)
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MP:0006117 | aortic valve stenosis | "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
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MP:0006126 | abnormal outflow tract development | "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)
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MP:0006128 | pulmonary valve stenosis | "abnormal narrowing of the pulmonary valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
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MP:0008182 | decreased marginal zone B cell number | "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149] |
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)
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MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ackr3tm1Jgo/Ackr3tm1Jgo Genetic Background: involves: 129S/SvEvBrd * C57BL/6
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MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: 4932438A13Riktm1b(EUCOMM)Hmgu/4932438A13Riktm1b(EUCOMM)Hmgu Genetic Background: B6N(Cg)-4932438A13Riktm1b(EUCOMM)Hmgu/J
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MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)
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MP:0010403 | atrial septal defect | "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375] |
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)
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MP:0010418 | perimembraneous ventricular septal defect | "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com] |
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Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
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MP:0010426 | abnormal heart and great artery attachment | "any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
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MP:0010594 | thick aortic valve | "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
Allelic Composition: Ackr3tm1Twb/Ackr3tm1.1Twb,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6
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MP:0010601 | thick pulmonary valve | "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
Allelic Composition: Ackr3tm1Twb/Ackr3tm1.1Twb,Tg(Tek-cre)12Flv/0 Genetic Background: involves: 129S/SvEv * BALB/cJ * C3H * C57BL/6
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Ackr3tm1Jgo/Ackr3tm1Jgo Genetic Background: involves: 129S/SvEvBrd * C57BL/6
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
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MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)
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MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Mcoln3Va-J/Mcoln3+ Genetic Background: B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
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MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Ackr3tm1.1Twb/Ackr3tm1.1Twb Genetic Background: involves: 129S/SvEv * BALB/cJ * C57BL/6
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MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H
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