ENSMUSG00000060735


Mus musculus

Features
Gene ID: ENSMUSG00000060735
  
Biological name :Rxfp3
  
Synonyms : Q8BGE9 / Relaxin-3 receptor 1 / Rxfp3
  
Possible biological names infered from orthology : Q9NSD7 / relaxin/insulin like family peptide receptor 3
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: A1
Gene start: 11033717
Gene end: 11037991
  
Corresponding Affymetrix probe sets: 10427766 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000062741
NCBI entrez gene - 239336     See in Manteia.
MGI - MGI:2441827
RefSeq - NM_178717
RefSeq Peptide - NP_848832
swissprot - Q5Y988
swissprot - Q8BGE9
Ensembl - ENSMUSG00000060735
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rxfp3ENSDARG00000057410Danio rerio
 RXFP3ENSGALG00000017411Gallus gallus
 RXFP3ENSG00000182631Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rxfp4 / Q7TQP4 / Relaxin-3 receptor 2 / Q8TDU9* / relaxin/insulin like family peptide receptor 4*ENSMUSG0000004974129
Agtr1a / P29754 / Type-1A angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*ENSMUSG0000004911523
Agtr1b / P29755 / Type-1B angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*ENSMUSG0000005498822
Agtr2 / P35374 / Type-2 angiotensin II receptor / P50052* / angiotensin II receptor type 2*ENSMUSG0000006812221
Aplnr / Q9WV08 / Apelin receptor / P35414*ENSMUSG0000004433820
Gpr25 / P0C5I1 / Probable G-protein coupled receptor 25 / O00155* / G protein-coupled receptor 25*ENSMUSG0000005275920
Bdkrb2 / P32299 / B2 bradykinin receptor / P30411* / bradykinin receptor B2*ENSMUSG0000002107020
Ackr3 / P56485 / atypical chemokine receptor 3 / P25106*ENSMUSG0000004433719
Bdkrb1 / Q61125 / B1 bradykinin receptor / P46663* / bradykinin receptor B1*ENSMUSG0000004134719
Gpr15 / Q0VDU3 / G-protein coupled receptor 15 / P49685*ENSMUSG0000004729318
Gpr182 / G protein-coupled receptor 182 / O15218*ENSMUSG0000005839617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IDA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IC
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004966 galanin receptor activity IBA
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IDA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Relaxin receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Scarb2tm1Psa/Scarb2tm1Psa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Scarb2tm1Psa/Scarb2tm1Psa
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045232 Rln3 / Q8CHK2 / Relaxin-3 Relaxin-3 B chain Relaxin-3 A chain / Q8WXF3* / relaxin 3*  / reaction / complex






 

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