Manteia

ENSMUSG00000045232

Mus musculus

Features

Gene ID:	ENSMUSG00000045232

Biological name :	Rln3

Synonyms :	Q8CHK2 / Relaxin-3 Relaxin-3 B chain Relaxin-3 A chain / Rln3

Possible biological names infered from orthology :	Q8WXF3 / relaxin 3

Species:	Mus musculus

Chr. number:	8
Strand:	-1
Band:	C2
Gene start:	84042929
Gene end:	84045000

Corresponding Affymetrix probe sets:	10580077 (MoGene1.0st)

Cross references:	Ensembl peptide - ENSMUSP00000051392 NCBI entrez gene - 212108 See in Manteia. MGI - MGI:2158015 RefSeq - NM_173184 RefSeq Peptide - NP_775276 swissprot - Q8CHK2 Ensembl - ENSMUSG00000045232

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
rln1	ENSDARG00000103762	Danio rerio
RLN3	ENSG00000171136	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR016179	Insulin-like
IPR022352	Insulin family
IPR022353	Insulin, conserved site
IPR036438	Insulin-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0010469	regulation of signaling receptor activity	IEA
biological_process	GO:0030819	obsolete positive regulation of cAMP biosynthetic process	ISO
cellular_component	GO:0005576	extracellular region	TAS
molecular_function	GO:0001664	G-protein coupled receptor binding	IEA
molecular_function	GO:0005179	hormone activity	IBA

Pathways (from Reactome)

Pathway description

G alpha (s) signalling events

G alpha (i) signalling events

Relaxin receptors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm Genetic Background: B6.129S-Rhbdf2^tm1.1Mfm
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm Genetic Background: B6.129S-Rhbdf2^tm1.1Mfm
MP:0001360	abnormal social investigation	"altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm Genetic Background: B6.129S-Rhbdf2^tm1.1Mfm
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: Trp53^tm1Brn/Trp53^tm1Brn,Trp53^tm2Tyj/Trp53^tm2Tyj Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm Genetic Background: B6.129S-Rhbdf2^tm1.1Mfm
MP:0001488	increased startle reflex	"reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Trp53^tm1Brn/Trp53^tm1Brn,Trp53^tm2Tyj/Trp53^tm2Tyj Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
MP:0002075	abnormal coat color	"irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002573	behavioral despair	"depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]	Show Allelic Composition: Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm Genetic Background: B6.129S-Rhbdf2^tm1.1Mfm
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm Genetic Background: B6.129S-Rhbdf2^tm1.1Mfm
MP:0004807	abnormal paired pulse inhibition	"defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Trp53^tm1Brn/Trp53^tm1Brn,Trp53^tm2Tyj/Trp53^tm2Tyj Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae
MP:0004892	increased adiponectin level	"greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm Genetic Background: B6.129S-Rhbdf2^tm1.1Mfm
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm Genetic Background: B6.129S-Rhbdf2^tm1.1Mfm
MP:0005668	decreased circulating leptin level	"less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm Genetic Background: B6.129S-Rhbdf2^tm1.1Mfm
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm Genetic Background: B6.129S-Rhbdf2^tm1.1Mfm
MP:0009299	decreased mesenteric fat pad weight		Show Allelic Composition: Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm Genetic Background: B6.129S-Rhbdf2^tm1.1Mfm
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm Genetic Background: B6.129S-Rhbdf2^tm1.1Mfm
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Psph^{tm1.1(KOMP)Vlcg}/Psph^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Psph^{tm1.1(KOMP)Vlcg}/Ucd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000049741	Rxfp4 / Q7TQP4 / Relaxin-3 receptor 2 / Q8TDU9* / relaxin/insulin like family peptide receptor 4*	/ complex / reaction
ENSMUSG00000034009	Rxfp1 / Q6R6I7 / Relaxin receptor 1 / Q9HBX9* / relaxin/insulin like family peptide receptor 1*	/ reaction / complex
ENSMUSG00000045232	Rln3 / Q8CHK2 / Relaxin-3 Relaxin-3 B chain Relaxin-3 A chain / Q8WXF3* / relaxin 3*	/ complex
ENSMUSG00000060735	Rxfp3 / Q8BGE9 / Relaxin-3 receptor 1 / Q9NSD7* / relaxin/insulin like family peptide receptor 3*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr