ENSMUSG00000034009


Mus musculus

Features
Gene ID: ENSMUSG00000034009
  
Biological name :Rxfp1
  
Synonyms : Q6R6I7 / Relaxin receptor 1 / Rxfp1
  
Possible biological names infered from orthology : Q9HBX9 / relaxin/insulin like family peptide receptor 1
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E3
Gene start: 79641611
Gene end: 79737880
  
Corresponding Affymetrix probe sets: 10498852 (MoGene1.0st)   1440785_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077611
Ensembl peptide - ENSMUSP00000138578
NCBI entrez gene - 381489     See in Manteia.
MGI - MGI:2682211
RefSeq - XM_006501630
RefSeq - NM_212452
RefSeq - XM_006501629
RefSeq Peptide - NP_997617
swissprot - S4R2B5
swissprot - Q6R6I7
Ensembl - ENSMUSG00000034009
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rxfp1ENSDARG00000090071Danio rerio
 RXFP1ENSGALG00000009429Gallus gallus
 RXFP1ENSG00000171509Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rxfp2 / Q91ZZ5 / Relaxin receptor 2 / Q8WXD0* / relaxin/insulin like family peptide receptor 2*ENSMUSG0000005336849
Lgr5 / Q9Z1P4 / Leucine-rich repeat-containing G-protein coupled receptor 5 / O75473*ENSMUSG0000002014022
Lgr6 / Q3UVD5 / Leucine-rich repeat-containing G-protein coupled receptor 6 / Q9HBX8*ENSMUSG0000004279320
Lgr4 / A2ARI4 / Leucine-rich repeat-containing G-protein coupled receptor 4 / Q9BXB1*ENSMUSG0000005019919
Lhcgr / P30730 / Lutropin-choriogonadotropic hormone receptor / P22888* / AC073082.1* / luteinizing hormone/choriogonadotropin receptor*ENSMUSG0000002410718
Tshr / P47750 / thyroid stimulating hormone receptor / P16473*ENSMUSG0000002096318
Fshr / P35378 / Follicle-stimulating hormone receptor / P23945*ENSMUSG0000003293716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001611  Leucine-rich repeat
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR008112  Relaxin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IGI
 biological_processGO:0007567 parturition IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0060427 lung connective tissue development IMP
 biological_processGO:0060658 nipple morphogenesis IMP
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042562 hormone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Relaxin receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
Show

Allelic Composition: Bhlhe23tm1Dbra/Bhlhe23+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Rxfp2tm1Aia/Rxfp2tm1Aia
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Tg(Ins2-Insl3)4Imad/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Rxfp2tm1Aia/Rxfp2tm1Aia
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002907 abnormal parturition "defect in the process of labor and delivery in female animals " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004929 decreased epididymis weight "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005149 abnormal gubernaculum morphology "dysmorphology of the genitoinguinal ligaments that, in the male, connect the fetal testis to the developing scrotum, and, in the female, connect the ovaries to the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55881]
Show

Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Tg(Ins2-Insl3)4Imad/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009722 abnormal nipple development "an anomaly in the differentiation of the apex of the mammary gland on the integument surface into which the lactiferous ducts open" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011727 ectopic ovary "appearance of an ovary in a region where it is not normally found (topographical anomaly)" [MGI:csmith]
Show

Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Tg(Ins2-Insl3)4Imad/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0013713 decreased nipple size "reduced size of the erectile projection at the apex of the mammary gland where the lactiferous ducts open" [ISBN:0-683-40008-8, MGI:Anna]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Rxfp2tm1Aia/Rxfp2tm1Aia
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Tg(Ins2-Insl3)4Imad/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039097 Rln1 / relaxin 1 / RLN2* / P04808* / P04090* / relaxin 2*  / reaction / complex
 ENSMUSG00000045232 Rln3 / Q8CHK2 / Relaxin-3 Relaxin-3 B chain Relaxin-3 A chain / Q8WXF3* / relaxin 3*  / reaction / complex






 

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