ENSMUSG00000020963


Mus musculus

Features
Gene ID: ENSMUSG00000020963
  
Biological name :Tshr
  
Synonyms : P47750 / thyroid stimulating hormone receptor / Tshr
  
Possible biological names infered from orthology : P16473
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D3
Gene start: 91384563
Gene end: 91549808
  
Corresponding Affymetrix probe sets: 10397606 (MoGene1.0st)   1421999_at (Mouse Genome 430 2.0 Array)   1428001_at (Mouse Genome 430 2.0 Array)   1442300_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139632
Ensembl peptide - ENSMUSP00000152158
Ensembl peptide - ENSMUSP00000021343
Ensembl peptide - ENSMUSP00000021346
NCBI entrez gene - 22095     See in Manteia.
MGI - MGI:98849
RefSeq - NM_001113404
RefSeq - NM_011648
RefSeq Peptide - NP_001106875
RefSeq Peptide - NP_035778
swissprot - Q78U67
swissprot - A0A087WP53
swissprot - P47750
swissprot - A0A1Y7VLF3
Ensembl - ENSMUSG00000020963
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tshrENSDARG00000037195Danio rerio
 TSHRENSGALG00000010572Gallus gallus
 TSHRENSG00000165409Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lhcgr / P30730 / Lutropin-choriogonadotropic hormone receptor / P22888* / AC073082.1* / luteinizing hormone/choriogonadotropin receptor*ENSMUSG0000002410748
Fshr / P35378 / Follicle-stimulating hormone receptor / P23945*ENSMUSG0000003293744
Lgr5 / Q9Z1P4 / Leucine-rich repeat-containing G-protein coupled receptor 5 / O75473*ENSMUSG0000002014024
Lgr6 / Q3UVD5 / Leucine-rich repeat-containing G-protein coupled receptor 6 / Q9HBX8*ENSMUSG0000004279323
Lgr4 / A2ARI4 / Leucine-rich repeat-containing G-protein coupled receptor 4 / Q9BXB1*ENSMUSG0000005019922
Rxfp1 / Q6R6I7 / Relaxin receptor 1 / Q9HBX9* / relaxin/insulin like family peptide receptor 1*ENSMUSG0000003400918
Rxfp2 / Q91ZZ5 / Relaxin receptor 2 / Q8WXD0* / relaxin/insulin like family peptide receptor 2*ENSMUSG0000005336818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001611  Leucine-rich repeat
 IPR002131  Glycoprotein hormone receptor family
 IPR002274  Thyrotropin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR026906  Leucine rich repeat 5
 IPR032675  Leucine-rich repeat domain superfamily
 IPR034298  TSH/LHCG/FSH receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway ISS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007190 activation of adenylate cyclase activity IBA
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030819 obsolete positive regulation of cAMP biosynthetic process ISO
 biological_processGO:0038194 thyroid-stimulating hormone signaling pathway IEA
 biological_processGO:0040012 regulation of locomotion IMP
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0045762 positive regulation of adenylate cyclase activity ISS
 biological_processGO:0060119 inner ear receptor cell development IMP
 biological_processGO:0060122 inner ear receptor cell stereocilium organization IMP
 biological_processGO:0071542 dopaminergic neuron differentiation IMP
 biological_processGO:0090103 cochlea morphogenesis IMP
 biological_processGO:1904588 cellular response to glycoprotein ISO
 biological_processGO:1905229 cellular response to thyrotropin-releasing hormone ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISS
 cellular_componentGO:0043235 receptor complex ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004996 thyroid-stimulating hormone receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IBA
 molecular_functionGO:0016500 protein-hormone receptor activity IEA
 molecular_functionGO:0044877 protein-containing complex binding ISS


Pathways (from Reactome)
Pathway description
Hormone ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000042 abnormal organ of Corti "abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

Allelic Composition: Tshrhyt-2J/Tshrhyt-2J
Genetic Background: B6;129P3-Tshrhyt-2J/GrsrJ

Allelic Composition: Tshrm1Btlr/Tshrm1Btlr
Genetic Background: C57BL/6J-Tshrm1Btlr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

Allelic Composition: Tshrhyt/Tshrhyt
Genetic Background: involves: BALB/cByJ * RF/J

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0001396 unidirectional circling "circling behavior in one direction only, either clockwise or counterclockwise" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Tshrhyt/Tshrhyt
Genetic Background: involves: BALB/cByJ * RF/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr2tm2.1Lni/Fgfr2tm2.1Lni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Fgfr2tm2.1Lni/Fgfr2tm2.1Lni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Plgtm1.1Fjc/Plgtm1.1Fjc
Genetic Background: involves: C57BL/6 * C57BL/6JJcl

Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CByJ;CXB10-Tshrhyt-3J/GrsrJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Plgtm1.1Fjc/Plgtm1.1Fjc
Genetic Background: involves: C57BL/6 * C57BL/6JJcl

Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CByJ;CXB10-Tshrhyt-3J/GrsrJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Tshrhyt/Tshrhyt
Genetic Background: involves: BALB/cByJ * RF/J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Tshrhyt/Tshrhyt
Genetic Background: involves: BALB/cByJ * RF/J

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plgtm1.1Fjc/Plgtm1.1Fjc
Genetic Background: involves: C57BL/6 * C57BL/6JJcl

Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CByJ;CXB10-Tshrhyt-3J/GrsrJ

 MP:0002876 abnormal thyroid physiology "anomalous function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr2tm2.1Lni/Fgfr2tm2.1Lni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0002951 small thyroid gland "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr2tm2.1Lni/Fgfr2tm2.1Lni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Tshrtm1Rmar/Tshrtm1Rmar,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr

Allelic Composition: Tshrtm1Rmar/Tshrtm1Rmar
Genetic Background: involves: 129S1/Sv

 MP:0002998 abnormal bone remodeling "aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0003194 abnormal frequency of paradoxical sleep "abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0003351 decreased circulating levels of thyroid hormone "reduced concentration of hormones in the blood that are synthesized and secreted by the thyroid" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Fgfr2tm2.1Lni/Fgfr2tm2.1Lni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0003356 impaired lutenization "atypical transformation of the mature ovarian follicle and its theca interna into a corpus luteum after ovulation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:57854, J:43075]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0003501 iodide oxidation defect "thyroid defect in oxidation and organification of iodide" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tshrtm1Rmar/Tshrtm1Rmar
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003503 decreased activity of thyroid 
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

Allelic Composition: Tshrtm1Rmar/Tshrtm1Rmar
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CXB10/HiAJ-Tshrhyt-3J/GrsrJ

Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CByJ;CXB10-Tshrhyt-3J/GrsrJ

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tshrhyt-2J/Tshrhyt-2J
Genetic Background: B6;129P3-Tshrhyt-2J/GrsrJ

 MP:0004014 abnormal uterine environment "anomaly or inability of the uterus to support embryonic development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tshrhyt-2J/Tshrhyt-2J
Genetic Background: B6;129P3-Tshrhyt-2J/GrsrJ

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0004527 abnormal outer hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0004529 decreased outer hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tshrtm1Rmar/Tshrtm1Rmar
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Tshrhyt/Tshrhyt
Genetic Background: involves: BALB/cByJ * RF/J

Allelic Composition: Tshrhyt-2J/Tshrhyt-2J
Genetic Background: B6;129P3-Tshrhyt-2J/GrsrJ

Allelic Composition: Braftm1Cpri/Braftm1Cpri,Tshrtm1Rmar/Tshrtm1Rmar,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr2tm2.1Lni/Fgfr2tm2.1Lni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tshrhyt/Tshrhyt
Genetic Background: involves: BALB/cByJ * RF/J

 MP:0005135 increased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tshrhyt/Tshrhyt
Genetic Background: involves: BALB/cByJ * RF/J

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0005468 abnormal thyroid hormone level "aberrant concentration of any of the hormones secreted by the thryoid gland" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:13923, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr2tm2.1Lni/Fgfr2tm2.1Lni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005471 decreased thyroxine level "less than the normal concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:13923]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr2tm2.1Lni/Fgfr2tm2.1Lni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tshrhyt/Tshrhyt
Genetic Background: involves: BALB/cByJ * RF/J

Allelic Composition: Tshrhyt-2J/Tshrhyt-2J
Genetic Background: B6;129P3-Tshrhyt-2J/GrsrJ

 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr2tm2.1Lni/Fgfr2tm2.1Lni
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0008337 increased thyrotroph cell number "greater number of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
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Allelic Composition: Tshrhyt-2J/Tshrhyt-2J
Genetic Background: B6;129P3-Tshrhyt-2J/GrsrJ

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CXB10/HiAJ-Tshrhyt-3J/GrsrJ

Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CByJ;CXB10-Tshrhyt-3J/GrsrJ

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0010316 increased thyroid tumor incidence "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Cpri/Braftm1Cpri,Tshrtm1Rmar/Tshrtm1Rmar,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Tshrtm1Rmar/Tshrtm1Rmar
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
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Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CXB10/HiAJ-Tshrhyt-3J/GrsrJ

Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CByJ;CXB10-Tshrhyt-3J/GrsrJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CXB10/HiAJ-Tshrhyt-3J/GrsrJ

Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CByJ;CXB10-Tshrhyt-3J/GrsrJ

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

Allelic Composition: Tshrhyt-3J/Tshrhyt-3J
Genetic Background: CXB10/HiAJ-Tshrhyt-3J/GrsrJ

Allelic Composition: Tshrhyt-2J/Tshrhyt-2J
Genetic Background: B6;129P3-Tshrhyt-2J/GrsrJ

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
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Allelic Composition: Tshrhyt-2J/Tshrhyt-2J
Genetic Background: B6;129P3-Tshrhyt-2J/GrsrJ

 MP:0013624 decreased femur compact bone thickness "reduced width of the superficial layer of compact bone at the midpoint of the femur" [MGI:csmith]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

 MP:0020010 decreased bone mineral density of femur "reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh" [GOC:NV]
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Allelic Composition: Slc9a1swe/Slc9a1swe
Genetic Background: SJL/J-Slc9a1swe/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024784 Gpha2 / Q925Q5 / glycoprotein hormone alpha 2 / Q96T91*  / complex / reaction
 ENSMUSG00000028298 Cga / P01216 / Glycoprotein hormones alpha chain / P01215* / glycoprotein hormones, alpha polypeptide*  / reaction / complex
 ENSMUSG00000027857 Tshb / thyroid stimulating hormone, beta subunit / P01222* / thyroid stimulating hormone beta*  / reaction / complex
 ENSMUSG00000048982 Gphb5 / Q812B2 / glycoprotein hormone beta 5 / Q86YW7*  / reaction / complex






 

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