ENSMUSG00000032937


Mus musculus

Features
Gene ID: ENSMUSG00000032937
  
Biological name :Fshr
  
Synonyms : Follicle-stimulating hormone receptor / Fshr / P35378
  
Possible biological names infered from orthology : P23945
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E5
Gene start: 88985170
Gene end: 89200612
  
Corresponding Affymetrix probe sets: 10453499 (MoGene1.0st)   1450810_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040477
NCBI entrez gene - 14309     See in Manteia.
MGI - MGI:95583
RefSeq - NM_013523
RefSeq Peptide - NP_038551
swissprot - B2RQM3
swissprot - P35378
Ensembl - ENSMUSG00000032937
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fshrENSDARG00000071494Danio rerio
 FSHRENSGALG00000009100Gallus gallus
 FSHRENSG00000170820Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lhcgr / P30730 / Lutropin-choriogonadotropic hormone receptor / P22888* / AC073082.1* / luteinizing hormone/choriogonadotropin receptor*ENSMUSG0000002410753
Tshr / P47750 / thyroid stimulating hormone receptor / P16473*ENSMUSG0000002096348
Lgr6 / Q3UVD5 / Leucine-rich repeat-containing G-protein coupled receptor 6 / Q9HBX8*ENSMUSG0000004279325
Lgr5 / Q9Z1P4 / Leucine-rich repeat-containing G-protein coupled receptor 5 / O75473*ENSMUSG0000002014025
Lgr4 / A2ARI4 / Leucine-rich repeat-containing G-protein coupled receptor 4 / Q9BXB1*ENSMUSG0000005019923
Rxfp2 / Q91ZZ5 / Relaxin receptor 2 / Q8WXD0* / relaxin/insulin like family peptide receptor 2*ENSMUSG0000005336820
Rxfp1 / Q6R6I7 / Relaxin receptor 1 / Q9HBX9* / relaxin/insulin like family peptide receptor 1*ENSMUSG0000003400918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR002131  Glycoprotein hormone receptor family
 IPR002272  Follicle stimulating hormone receptor
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR024635  Gonadotropin hormone receptor, transmembrane domain
 IPR026906  Leucine rich repeat 5
 IPR032675  Leucine-rich repeat domain superfamily
 IPR034298  TSH/LHCG/FSH receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0001545 primary ovarian follicle growth IMP
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0003073 regulation of systemic arterial blood pressure IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007190 activation of adenylate cyclase activity IBA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0009992 cellular water homeostasis IMP
 biological_processGO:0010640 regulation of platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0010738 regulation of protein kinase A signaling ISS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0022602 ovulation cycle process IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0032350 regulation of hormone metabolic process IMP
 biological_processGO:0033044 regulation of chromosome organization IMP
 biological_processGO:0033146 regulation of intracellular estrogen receptor signaling pathway IMP
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IMP
 biological_processGO:0035092 sperm chromatin condensation IMP
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins IMP
 biological_processGO:0042699 follicle-stimulating hormone signaling pathway ISO
 biological_processGO:0043408 regulation of MAPK cascade IMP
 biological_processGO:0045056 transcytosis IEA
 biological_processGO:0045670 regulation of osteoclast differentiation IMP
 biological_processGO:0045762 positive regulation of adenylate cyclase activity ISS
 biological_processGO:0045779 negative regulation of bone resorption IMP
 biological_processGO:0060009 Sertoli cell development IMP
 biological_processGO:0060011 Sertoli cell proliferation IMP
 biological_processGO:0060065 uterus development IMP
 biological_processGO:0060408 regulation of acetylcholine metabolic process IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus ISS
 biological_processGO:0071711 basement membrane organization IMP
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004963 follicle-stimulating hormone receptor activity ISO
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IBA
 molecular_functionGO:0016500 protein-hormone receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA


Pathways (from Reactome)
Pathway description
Hormone ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0001140 abnormal vaginal epithelium "malformation of the epithelial layer of the vagina" [J:54637, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001142 abnormal vaginal opening "a malformed or absent opening to the genital canal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Rargtm1Ipc/Rargtm1Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S-Serpine1tm1Mlg Ldlrtm1Her

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0002293 long gestation period "increase in the average duration of a pregnancy " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0002637 small uterus "reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

 MP:0002660 abnormal caput "anomalous structure of the head of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0002661 abnormal corpus "anomalous structure of the body of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0002678 increased follicle recruitment 
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0002782 abnormal testicular secretion "malfunction of the production and/or release of hormones from testicular tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002783 abnormal ovarian secretion "malfunction of the production and/or release of hormones from ovarian tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0003195 calcinosis "pathologic deposition of calcium salts in tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0003507 abnormal ovary physiology "anomaly or loss either the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0003529 enlarged clitoris "increased size of the small, erectile body located at the anterior end of the vulva" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0003579 ovarian carcinoma 
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0004014 abnormal uterine environment "anomaly or inability of the uterus to support embryonic development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0004834 ovary hemorrhage "presence of bleeding in the ovary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lama1nmf223/Lama1tm1.1Olf
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Fshrtm1Hht/Fshrtm1Hht
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004849 abnormal testis size "anomaly in the size of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0004894 uterus atrophy "wasting of the uterus due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0004895 vagina atrophy "wasting of the vagina due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0004898 uterine hemorrhage "presence of bleeding in the uterus; often in response to failed pregnancy" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0004904 increased uterus weight "increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0004906 enlarged uterus 
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0004929 decreased epididymis weight "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0004930 small epididymis "decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0004933 abnormal epididymis epithelium morphology "any structural anomaly of the layer of secretory cells which lines the epididymis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0005131 increased follicle stimulating hormone level "greater than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0005133 increased luteinizing hormone level "higher than normal levels of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0005250 Sertoli cell hypoplasia "decreased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:70212]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0006361 abnormal female germ cell morphology "any structural anomaly female germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: C57BL/6

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0008334 increased gonadotroph cell number "greater number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0008337 increased thyrotroph cell number "greater number of an anterior pituitary cell that produces thyroid-stimulating hormone" [MESH:A06.407.747.608.968]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0008868 abnormal granulosa cell morphology "any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle" [MESH:A.05.360.319.114.630.535.200]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0008869 anovulation "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0008975 delayed male fertility "ability of a male organism to produce live offspring occurring at a later than expected age" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0008976 delayed female fertility "ability of a female organism to produce live offspring occurring at a later than expected age" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0008980 decreased vagina weight "decrease in the weight of the female reproductive canal located between the uterus and the vulva" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0008994 early vaginal opening "the opening of the genital canal in a female occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0009016 abnormal estrus "any anomaly or aberrant timing of the phase of the estrous cycle which begins with the ovulation of fully mature oocytes and during which the vulva remains in an extended state with an open vagina, and females are maximally receptive to male advances" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0009081 thin uterus "reduced thickness or depth of the female muscular organ of gestation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0009082 uterus cysts "presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0009090 myometrium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0009093 oocyte degeneration "a retrogressive impairment of function or destruction of the female germ cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0009094 abnormal endometrial gland morphology "any structural anomaly of the numerous simple or branched tubular glands lined by ciliated columnar epithelium and found in the mucus membrane of the uterus which secrete mucus, lipids, glycogen, and protein; endometrial glands and their secretions (termed histotroph) are critical regulators of peri-implantation embryo survival and implantation as well as establishment of uterine receptivity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0009221 uterus adenomyosis "a benign invasion of myometrium by endometrial tissue" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0009222 uterus tumor "presence of abnormal rapidly proliferating cells in the uterus, usually in the form of a distinct mass" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0009233 enlarged sperm head "increased size of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0009248 small caput "decrease in the average size of the head of the epididymis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0009251 enlarged endometrial glands "increase in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129T2/SvEmsJ

 MP:0009433 polyovular ovarian follicle "an ovarian follicle containing more than one oocyte (ovum)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: 129/Sv

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf9tm1b(KOMP)Wtsi/Fgf9tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Fgf9tm1b(KOMP)Wtsi/H

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0011125 decreased primary ovarian follicle number "fewer than normal numbers of the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca" [MGI:csmith]
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Allelic Composition: Fshrtm1Saco/Fshr+
Genetic Background: involves: 129/Sv

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

 MP:0013348 adenohypophysis hyperplasia " overdevelopment or increased size of the anterior lobe of the pituitary gland, usually due to increased cell number" [MGI:Anna]
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Allelic Composition: Fshrtm1Saco/Fshrtm1Saco
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028298 Cga / P01216 / Glycoprotein hormones alpha chain / P01215* / glycoprotein hormones, alpha polypeptide*  / reaction / complex
 ENSMUSG00000027120 Fshb / Q60687 / Follitropin subunit beta / P01225* / follicle stimulating hormone beta subunit*  / reaction / complex






 

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