ENSMUSG00000027120


Mus musculus

Features
Gene ID: ENSMUSG00000027120
  
Biological name :Fshb
  
Synonyms : Follitropin subunit beta / Fshb / Q60687
  
Possible biological names infered from orthology : follicle stimulating hormone beta subunit / P01225
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E3
Gene start: 107056140
Gene end: 107059656
  
Corresponding Affymetrix probe sets: 10485681 (MoGene1.0st)   1450996_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028533
NCBI entrez gene - 14308     See in Manteia.
MGI - MGI:95582
RefSeq - NM_008045
RefSeq Peptide - NP_032071
swissprot - A0A0F7RQR1
swissprot - Q60687
Ensembl - ENSMUSG00000027120
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fshbENSDARG00000010841Danio rerio
 FSHBENSGALG00000012140Gallus gallus
 FSHBENSG00000131808Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tshb / thyroid stimulating hormone, beta subunit / P01222* / thyroid stimulating hormone beta*ENSMUSG0000002785737
Lhb / CGB1* / CGB2* / CGB3* / CGB5* / CGB7* / CGB8* / A6NKQ9* / P01229* / P0DN86* / P0DN87* / AC008687.1* / luteinizing hormone beta polypeptide* / chorionic gonadotropin beta subunit 1* / ...ENSMUSG0000010091635


Protein motifs (from Interpro)
Interpro ID Name
 IPR001545  Gonadotropin, beta subunit
 IPR006208  Glycoprotein hormone subunit beta
 IPR018245  Gonadotropin, beta subunit, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0042699 follicle-stimulating hormone signaling pathway IMP
 biological_processGO:0045670 regulation of osteoclast differentiation IMP
 biological_processGO:0045780 positive regulation of bone resorption IMP
 biological_processGO:0060011 Sertoli cell proliferation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0016913 follicle-stimulating hormone activity ISO


Pathways (from Reactome)
Pathway description
Glycoprotein hormones
Hormone ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002637 small uterus "reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005130 decreased follicle stimulating hormone level "less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata4tm1Eno/Gata4tm1Eno
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm1Sho/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028298 Cga / P01216 / Glycoprotein hormones alpha chain / P01215* / glycoprotein hormones, alpha polypeptide*  / complex / reaction
 ENSMUSG00000032937 Fshr / P35378 / Follicle-stimulating hormone receptor / P23945*  / reaction / complex






 

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