ENSMUSG00000027857


Mus musculus

Features
Gene ID: ENSMUSG00000027857
  
Biological name :Tshb
  
Synonyms : thyroid stimulating hormone, beta subunit / Tshb
  
Possible biological names infered from orthology : P01222 / thyroid stimulating hormone beta
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.2
Gene start: 102775465
Gene end: 102782718
  
Corresponding Affymetrix probe sets: 10500748 (MoGene1.0st)   1450371_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127165
Ensembl peptide - ENSMUSP00000142670
Ensembl peptide - ENSMUSP00000142782
Ensembl peptide - ENSMUSP00000029450
Ensembl peptide - ENSMUSP00000128440
NCBI entrez gene - 22094     See in Manteia.
MGI - MGI:98848
RefSeq - XM_017319535
RefSeq - NM_001165939
RefSeq - NM_001165940
RefSeq - NM_009432
RefSeq - XM_006501301
RefSeq - XM_006501304
RefSeq - XM_006501305
RefSeq Peptide - NP_001159411
RefSeq Peptide - NP_001159412
RefSeq Peptide - NP_033458
swissprot - E9Q4F3
Ensembl - ENSMUSG00000027857
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU929146.1ENSDARG00000110110Danio rerio
 tshbaENSDARG00000033726Danio rerio
 TSHBENSGALG00000002550Gallus gallus
 TSHBENSG00000134200Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fshb / Q60687 / Follitropin subunit beta / P01225* / follicle stimulating hormone beta subunit*ENSMUSG0000002712035
Lhb / CGB1* / CGB2* / CGB3* / CGB5* / CGB7* / CGB8* / A6NKQ9* / P01229* / P0DN86* / P0DN87* / AC008687.1* / luteinizing hormone beta polypeptide* / chorionic gonadotropin beta subunit 1* / ...ENSMUSG0000010091634


Protein motifs (from Interpro)
Interpro ID Name
 IPR001545  Gonadotropin, beta subunit
 IPR006208  Glycoprotein hormone subunit beta
 IPR018245  Gonadotropin, beta subunit, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0051592 response to calcium ion IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
Glycoprotein hormones
Thyroxine biosynthesis
Hormone ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: CiartGt(IST11761C7)Tigm/CiartGt(IST11761C7)Tigm
Genetic Background: C57BL/6-CiartGt(IST11761C7)Tigm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028298 Cga / P01216 / Glycoprotein hormones alpha chain / P01215* / glycoprotein hormones, alpha polypeptide*  / reaction / complex
 ENSMUSG00000020963 Tshr / P47750 / thyroid stimulating hormone receptor / P16473*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr