ENSMUSG00000100916


Mus musculus

Features
Gene ID: ENSMUSG00000100916
  
Biological name :Lhb
  
Synonyms : Lhb
  
Possible biological names infered from orthology : A6NKQ9 / AC008687.1 / CGB1 / CGB2 / CGB3 / CGB5 / CGB7 / CGB8 / chorionic gonadotropin beta subunit 1 / chorionic gonadotropin beta subunit 2 / chorionic gonadotropin beta subunit 3 / chorionic gonadotropin beta subunit 5 / chorionic gonadotropin beta subunit 7 / chorionic gonadotropin beta subunit 8 / luteinizing hormone beta polypeptide / P01229 / P0DN86 / P0DN87
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 45420820
Gene end: 45421897
  
Corresponding Affymetrix probe sets: 10552942 (MoGene1.0st)   1450795_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072276
NCBI entrez gene - 16866     See in Manteia.
MGI - MGI:96782
RefSeq - NM_008497
RefSeq - XM_011250810
RefSeq Peptide - NP_032523
swissprot - G3X9G6
Ensembl - ENSMUSG00000100916
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lhbENSDARG00000099363Danio rerio
 AC008687.1ENSG00000267335Homo sapiens
 CGB1ENSG00000267631Homo sapiens
 CGB2ENSG00000104818Homo sapiens
 CGB3ENSG00000104827Homo sapiens
 CGB5ENSG00000189052Homo sapiens
 CGB7ENSG00000196337Homo sapiens
 CGB8ENSG00000213030Homo sapiens
 LHBENSG00000104826Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tshb / thyroid stimulating hormone, beta subunit / P01222* / thyroid stimulating hormone beta*ENSMUSG0000002785733
Fshb / Q60687 / Follitropin subunit beta / P01225* / follicle stimulating hormone beta subunit*ENSMUSG0000002712033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001545  Gonadotropin, beta subunit
 IPR006208  Glycoprotein hormone subunit beta
 IPR018245  Gonadotropin, beta subunit, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
Androgen biosynthesis
Mineralocorticoid biosynthesis
Glycoprotein hormones
Hormone ligand-binding receptors
G alpha (s) signalling events
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Reactions specific to the complex N-glycan synthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001116 small gonad "reduced size of the testis or the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001121 uterine hypoplasia "reduced size of the uterus due to decreased cell number" [J:45065]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002774 small prostate "reduced size of the gland in males that secretes part of the seminiferous fluid" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002779 abnormal sex gland secretion "malfunction of the production and/or release of hormones from a cell or a gland of the reproductive system " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0003527 small vulva "decreased size of the external genitalia of the female" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0004930 small epididymis "decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0005536 Leydig cell hypoplasia "reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0008258 thin endometrium "reduced thickness of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0009202 small external male genitalia 
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0013602 abnormal Leydig cell differentiation "atypical formation of or inability to produce the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone; in most mammals, normal Leydig cell (LC) development comprises two sequential but overlapping cell lineages known as the fetal and adult type LC populations, which display distinct functional characteristics reflected by different morphology, hormonal regulation, and steroidogenic output" [http://press.endocrine.org/doi/full/10.1210/en.2012-2273, MGI:Anna]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0013737 small bulbourethral gland "reduced size of either of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, between the two layers of the fascia of the urogenital diaphragm, in the deep perineal pouch, and enclosed by transverse fibers of the sphincter urethrae membranaceae muscle" [MGI:Anna, PMID:19117991]
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Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028298 Cga / P01216 / Glycoprotein hormones alpha chain / P01215* / glycoprotein hormones, alpha polypeptide*  / complex / reaction
 ENSMUSG00000024107 Lhcgr / P30730 / Lutropin-choriogonadotropic hormone receptor / P22888* / AC073082.1* / luteinizing hormone/choriogonadotropin receptor*  / reaction / complex
 ENSMUSG00000060402 Chst8 / Q8BQ86 / Carbohydrate sulfotransferase 8 / Q9H2A9*  / reaction






 

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