ENSMUSG00000060402


Mus musculus

Features
Gene ID: ENSMUSG00000060402
  
Biological name :Chst8
  
Synonyms : Carbohydrate sulfotransferase 8 / Chst8 / Q8BQ86
  
Possible biological names infered from orthology : Q9H2A9
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B2
Gene start: 34674468
Gene end: 34812711
  
Corresponding Affymetrix probe sets: 10562408 (MoGene1.0st)   1428977_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077752
Ensembl peptide - ENSMUSP00000123498
Ensembl peptide - ENSMUSP00000145646
NCBI entrez gene - 68947     See in Manteia.
MGI - MGI:1916197
RefSeq - XM_006540341
RefSeq - NM_175140
RefSeq - XM_006540337
RefSeq - XM_006540339
RefSeq - XM_006540340
RefSeq Peptide - NP_780349
swissprot - Q8BQ86
swissprot - D6RCV4
Ensembl - ENSMUSG00000060402
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-269c21.2ENSDARG00000074560Danio rerio
 CHST8ENSGALG00000004903Gallus gallus
 CHST8ENSG00000124302Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chst9 / Q76EC5 / Carbohydrate sulfotransferase 9 / Q7L1S5*ENSMUSG0000004716149
Chst11 / Q9JME2 / Carbohydrate sulfotransferase 11 / Q9NPF2*ENSMUSG0000003461230
Chst12 / Q99LL3 / Carbohydrate sulfotransferase 12 / Q9NRB3*ENSMUSG0000003659930
Chst13 / carbohydrate (chondroitin 4) sulfotransferase 13 / Q8NET6* / carbohydrate sulfotransferase 13*ENSMUSG0000005664328
Chst14 / Q80V53 / Carbohydrate sulfotransferase 14 / Q8NCH0*ENSMUSG0000007491627
Chst10 / carbohydrate sulfotransferase 10 / O43529*ENSMUSG0000002608025


Protein motifs (from Interpro)
Interpro ID Name
 IPR005331  Sulfotransferase
 IPR018011  Carbohydrate sulfotransferase 8-10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006790 sulfur compound metabolic process ISO
 biological_processGO:0016051 carbohydrate biosynthetic process IEA
 biological_processGO:0016486 peptide hormone processing TAS
 biological_processGO:0030166 proteoglycan biosynthetic process ISS
 biological_processGO:0042446 hormone biosynthetic process ISS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity ISS
 molecular_functionGO:0008146 sulfotransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Reactions specific to the complex N-glycan synthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0001128 ovary hyperplasia "increased cell number in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0001934 increased litter size "greater numbers of live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0002681 increased number of corpora lutea "greater than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0002783 abnormal ovarian secretion "malfunction of the production and/or release of hormones from ovarian tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0002808 barbering "the biting and ingesting of hair (self, mate, pups); recognized as patches of unevenly chopped hair; seldom is the underlying skin inflamed" [What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0003378 early sexual maturation "pubertal changes occur at an earlier than normal age" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0004851 increased testis weight "greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0004904 increased uterus weight "increase in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0004909 increased seminal gland weight "increase in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0004928 increased epididymis weight "increase in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dclre1ctm1.1Jpdv/Dclre1ctm1.1Jpdv
Genetic Background: involves: 129P1/ReJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000100916 Lhb / CGB1* / CGB2* / CGB3* / CGB5* / CGB7* / CGB8* / A6NKQ9* / P01229* / P0DN86* / P0DN87* / AC008687.1* / luteinizing hormone beta polypeptide* / chorionic gonadotropin beta subunit 1* / ...  / reaction
 ENSMUSG00000028298 Cga / P01216 / Glycoprotein hormones alpha chain / P01215* / glycoprotein hormones, alpha polypeptide*  / reaction






 

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