ENSMUSG00000034612


Mus musculus

Features
Gene ID: ENSMUSG00000034612
  
Biological name :Chst11
  
Synonyms : Carbohydrate sulfotransferase 11 / Chst11 / Q9JME2
  
Possible biological names infered from orthology : Q9NPF2
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 82985498
Gene end: 83195900
  
Corresponding Affymetrix probe sets: 10365290 (MoGene1.0st)   1428902_at (Mouse Genome 430 2.0 Array)   1450509_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045349
NCBI entrez gene - 58250     See in Manteia.
MGI - MGI:1927166
RefSeq - XM_006513909
RefSeq - NM_021439
RefSeq - XM_006513908
RefSeq Peptide - NP_067414
swissprot - Q9JME2
swissprot - B9EHC3
Ensembl - ENSMUSG00000034612
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chst11ENSDARG00000034375Danio rerio
 CHST11ENSGALG00000030607Gallus gallus
 CHST11ENSG00000171310Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chst13 / carbohydrate (chondroitin 4) sulfotransferase 13 / Q8NET6* / carbohydrate sulfotransferase 13*ENSMUSG0000005664344
Chst12 / Q99LL3 / Carbohydrate sulfotransferase 12 / Q9NRB3*ENSMUSG0000003659938
Chst8 / Q8BQ86 / Carbohydrate sulfotransferase 8 / Q9H2A9*ENSMUSG0000006040235
Chst9 / Q76EC5 / Carbohydrate sulfotransferase 9 / Q7L1S5*ENSMUSG0000004716132
Chst14 / Q80V53 / Carbohydrate sulfotransferase 14 / Q8NCH0*ENSMUSG0000007491631
Chst10 / carbohydrate sulfotransferase 10 / O43529*ENSMUSG0000002608028


Protein motifs (from Interpro)
Interpro ID Name
 IPR005331  Sulfotransferase
 IPR018011  Carbohydrate sulfotransferase 8-10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002063 chondrocyte development IMP
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0016051 carbohydrate biosynthetic process IEA
 biological_processGO:0030204 chondroitin sulfate metabolic process IMP
 biological_processGO:0030206 chondroitin sulfate biosynthetic process IEA
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0033037 polysaccharide localization IMP
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0048704 embryonic skeletal system morphogenesis IMP
 biological_processGO:0051216 cartilage development IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity ISO
 molecular_functionGO:0008146 sulfotransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0047756 chondroitin 4-sulfotransferase activity ISO
 molecular_functionGO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IDA


Pathways (from Reactome)
Pathway description
Chondroitin sulfate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0000440 domed skull 
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Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0003826 abnormal Mullerian duct morphology "malformation of the transient embryonic tubes that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004343 small scapula "reduced size of either or both of the large, flat bones of the back part of the shoulder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0005109 abnormal talus morphology "malformation of the bone that articlulates with the tibia and fibula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0005354 abnormal ilium morphology "structural anomaly of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0008151 increased diameter of long bones "increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0010484 bicuspid aortic valve "the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]
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Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010530 cerebral arteriovenous malformation "congenital vascular anomaly in the cerebrum characterized by direct communication between an artery and a vein without passing through the capillary bed" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011493 double ureter "two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues" [http://emedicine.medscape.com/article/378075-overview, MGI:anna]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0012303 umbilical vein stenosis "abnormal constriction or narrowing of the unpaired umbilical vein that carries oxygenated, nutrient-rich blood from the placenta to the fetus" [MGI:anna]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013842 ductus venosus stenosis "narrowing of the lumen of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein that allows oxygenated blood to bypass the developing liver during the time when this connection is normally open; this normally closes during develpment to adulthood" [MGI:csmith]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013843 hepatic portal vein stenosis "narrowing of the lumen of the wide short vein formed from the confluence of the superior mesenteric, inferior mesenteric and splenic veins, which then divides into the right and left branches which ramify with the liver; the hepatic portal vein carries venous blood from the GI tract, spleen and pancreas to the liver" [ISBN:0-683-40008-8]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013844 abnormal perichondrial ossification "formation of bone in the perichondrium, which is normally cartilaginous" [MGI:csmith]
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Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013845 abnormal eye muscle topology "abnormal position of eye muscles" [MGI:csmith]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013859 abnormal vitelline vein connection "aberrant or missing attachment of the paired veins that carry blood from the yolk sac back to the embryo" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013971 blood in lymph vessels 
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Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013986 abnormal vitelline vein topology "abnormal position of the paired veins that carry blood from the yolk sac back to the embryo" [MGI:csmith]
Show

Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0014001 abnormal vertebral artery topology "abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith]
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Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0014003 additional anastomosis between intracranial vertebral arteries 
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Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0014019 embryo cyst 
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Allelic Composition: Bach2tm1a(EUCOMM)Wtsi/Bach2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Bach2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0030384 short facial bone "length reduction or truncation of one or more facial bones" [MGI:anna]
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Allelic Composition: Hephsla/Hephsla
Genetic Background: B6.Cg-Hephsla

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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