ENSMUSG00000074916


Mus musculus

Features
Gene ID: ENSMUSG00000074916
  
Biological name :Chst14
  
Synonyms : Carbohydrate sulfotransferase 14 / Chst14 / Q80V53
  
Possible biological names infered from orthology : Q8NCH0
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 118926496
Gene end: 118928585
  
Corresponding Affymetrix probe sets: 10474860 (MoGene1.0st)   1426866_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106461
Ensembl peptide - ENSMUSP00000099579
NCBI entrez gene - 72136     See in Manteia.
MGI - MGI:1919386
RefSeq - NM_028117
RefSeq Peptide - NP_082393
swissprot - A2AQV2
swissprot - Q80V53
Ensembl - ENSMUSG00000074916
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chst14ENSDARG00000043011Danio rerio
 ENSGALG00000026531Gallus gallus
 CHST14ENSG00000169105Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chst13 / carbohydrate (chondroitin 4) sulfotransferase 13 / Q8NET6* / carbohydrate sulfotransferase 13*ENSMUSG0000005664331
Chst8 / Q8BQ86 / Carbohydrate sulfotransferase 8 / Q9H2A9*ENSMUSG0000006040230
Chst11 / Q9JME2 / Carbohydrate sulfotransferase 11 / Q9NPF2*ENSMUSG0000003461229
Chst12 / Q99LL3 / Carbohydrate sulfotransferase 12 / Q9NRB3*ENSMUSG0000003659928
Chst9 / Q76EC5 / Carbohydrate sulfotransferase 9 / Q7L1S5*ENSMUSG0000004716126
Chst10 / carbohydrate sulfotransferase 10 / O43529*ENSMUSG0000002608022


Protein motifs (from Interpro)
Interpro ID Name
 IPR005331  Sulfotransferase
 IPR018011  Carbohydrate sulfotransferase 8-10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0016051 carbohydrate biosynthetic process IEA
 biological_processGO:0030208 dermatan sulfate biosynthetic process ISO
 biological_processGO:0050655 dermatan sulfate proteoglycan metabolic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008146 sulfotransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Dermatan sulfate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001106 abnormal Schwann cell "malformed or absent cells which form the insulating myelin sheaths of peripheral axons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0003889 enhanced sensorimotor gating 
Show

Allelic Composition: Bhlha15tm3(cre/ERT2)Skz/Bhlha15tm3(cre/ERT2)Skz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

 MP:0011906 increased Schwann cell proliferation "increase in the expansion rate of a Schwann cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Msx1tm1Rilm/Msx1tm1Rilm,Msx2tm1Rilm/Msx2tm1Rilm
Genetic Background: involves: 129S4/SvJae * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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