ENSDARG00000099363


Danio rerio

Features
Gene ID: ENSDARG00000099363
  
Biological name :lhb
  
Synonyms : lhb / luteinizing hormone, beta polypeptide
  
Possible biological names infered from orthology : A6NKQ9 / AC008687.1 / CGB1 / CGB2 / CGB3 / CGB5 / CGB7 / CGB8 / chorionic gonadotropin beta subunit 1 / chorionic gonadotropin beta subunit 2 / chorionic gonadotropin beta subunit 3 / chorionic gonadotropin beta subunit 5 / chorionic gonadotropin beta subunit 7 / chorionic gonadotropin beta subunit 8 / P01229 / P0DN86 / P0DN87
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 2523032
Gene end: 2526033
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000130032
NCBI entrez gene - 402917     See in Manteia.
RefSeq - NM_205622
RefSeq Peptide - NP_991185
swissprot - Q6TCF5
ZFIN ID - ZDB-GENE-040806-2
Ensembl - ENSDARG00000099363
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AC008687.1ENSG00000267335Homo sapiens
 CGB1ENSG00000267631Homo sapiens
 CGB2ENSG00000104818Homo sapiens
 CGB3ENSG00000104827Homo sapiens
 CGB5ENSG00000189052Homo sapiens
 CGB7ENSG00000196337Homo sapiens
 CGB8ENSG00000213030Homo sapiens
 LHBENSG00000104826Homo sapiens
 LhbENSMUSG00000100916Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fshb / follicle stimulating hormone, beta polypeptide / P01225* / Q60687* / Follitropin subunit beta * / follicle stimulating hormone beta subunit*ENSDARG0000001084130
tshba / thyroid stimulating hormone, beta subunit, a / TSHB* / P01222* / thyroid stimulating hormone beta* / thyroid stimulating hormone, beta subunit*ENSDARG0000003372627
CU929146.1 / TSHB* / P01222* / thyroid stimulating hormone beta* / thyroid stimulating hormone, beta subunit*ENSDARG0000011011026


Protein motifs (from Interpro)
Interpro ID Name
 IPR001545  Gonadotropin, beta subunit
 IPR006208  Glycoprotein hormone subunit beta
 IPR018245  Gonadotropin, beta subunit, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IMP
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0007530 sex determination IGI
 biological_processGO:0008585 female gonad development IGI
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030728 ovulation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005179 hormone activity IDA


Pathways (from Reactome)
Pathway description
Androgen biosynthesis
Mineralocorticoid biosynthesis
Glycoprotein hormones
Hormone ligand-binding receptors
G alpha (s) signalling events
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Reactions specific to the complex N-glycan synthesis pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood testosterone decreased amount , abnormal
blood androgen decreased amount , abnormal
Show

 ZFA:0000118 hypophysis hypophysis absent , abnormal
Show

 ZFA:0000242 male organism male organism sterile , abnormal
Show

 ZFA:0000303 female organism female organism female sterile , abnormal
female organism absent , abnormal
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 ZFA:0000403 ovary ovary increased weight , abnormal
ovary increased size , abnormal
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 ZFA:0000598 testis testis decreased weight , abnormal
testis increased amount , abnormal
testis decreased size , abnormal
testis decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism female sterile , abnormal
whole organism semi-lethal (sensu genetics) , abnormal
whole organism dead , abnormal
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 ZFA:0001264 ovarian follicle stage IV ovarian follicle stage IV absent , abnormal
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 ZFA:0001266 ovarian follicle stage III ovarian follicle stage III decreased amount , abnormal
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 ZFA:0001568 oocyte stage IV oocyte stage IV absent , abnormal
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 ZFA:0001571 postovulatory follicle postovulatory follicle absent , abnormal
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 ZFA:0009006 sperm sperm decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000040479 cga / glycoprotein hormones, alpha polypeptide / P01215* / P01216* / Glycoprotein hormones alpha chain *  / complex / reaction
 ENSDARG00000074560 si:ch211-269c21.2 / CHST8* / Q9H2A9* / carbohydrate sulfotransferase 8*  / reaction






 

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