ENSDARG00000010841


Danio rerio

Features
Gene ID: ENSDARG00000010841
  
Biological name :fshb
  
Synonyms : follicle stimulating hormone, beta polypeptide / fshb
  
Possible biological names infered from orthology : follicle stimulating hormone beta subunit / Follitropin subunit beta / P01225 / Q60687
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 32605705
Gene end: 32612560
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000109046
Ensembl peptide - ENSDARP00000142706
NCBI entrez gene - 402919     See in Manteia.
RefSeq - NM_205624
RefSeq Peptide - NP_991187
swissprot - Q6TCF7
ZFIN ID - ZDB-GENE-040806-1
Ensembl - ENSDARG00000010841
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FSHBENSGALG00000012140Gallus gallus
 FSHBENSG00000131808Homo sapiens
 FshbENSMUSG00000027120Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lhb / luteinizing hormone, beta polypeptide / CGB2* / CGB3* / CGB1* / CGB7* / CGB8* / CGB5* / A6NKQ9* / P01229* / P0DN86* / P0DN87* / AC008687.1* / chorionic gonadotropin beta subunit 2* / ...ENSDARG0000009936332
CU929146.1 / TSHB* / P01222* / thyroid stimulating hormone beta* / thyroid stimulating hormone, beta subunit*ENSDARG0000011011032
tshba / thyroid stimulating hormone, beta subunit, a / TSHB* / P01222* / thyroid stimulating hormone beta* / thyroid stimulating hormone, beta subunit*ENSDARG0000003372624


Protein motifs (from Interpro)
Interpro ID Name
 IPR001545  Gonadotropin, beta subunit
 IPR006208  Glycoprotein hormone subunit beta
 IPR018245  Gonadotropin, beta subunit, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0007530 sex determination IMP
 biological_processGO:0008585 female gonad development IMP
 biological_processGO:0009755 hormone-mediated signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042699 follicle-stimulating hormone signaling pathway IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005179 hormone activity IDA
 molecular_functionGO:0016913 follicle-stimulating hormone activity IBA


Pathways (from Reactome)
Pathway description
Glycoprotein hormones
Hormone ligand-binding receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000075 spinal cord spinal cord curved , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
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 ZFA:0000303 female organism female organism female semi-sterile , abnormal
female organism decreased fertility , abnormal
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 ZFA:0000403 ovary ovary decreased size , abnormal
ovary immature , abnormal
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 ZFA:0000598 testis testis decreased size , abnormal
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 ZFA:0001264 ovarian follicle stage IV ovarian follicle stage IV decreased amount , abnormal
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 ZFA:0001266 ovarian follicle stage III ovarian follicle stage III decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000040479 cga / glycoprotein hormones, alpha polypeptide / P01215* / P01216* / Glycoprotein hormones alpha chain *  / complex / reaction






 

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