ENSMUSG00000053368


Mus musculus

Features
Gene ID: ENSMUSG00000053368
  
Biological name :Rxfp2
  
Synonyms : Q91ZZ5 / Relaxin receptor 2 / Rxfp2
  
Possible biological names infered from orthology : Q8WXD0 / relaxin/insulin like family peptide receptor 2
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G3
Gene start: 150018675
Gene end: 150082184
  
Corresponding Affymetrix probe sets: 10527713 (MoGene1.0st)   1421532_at (Mouse Genome 430 2.0 Array)   1440704_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144536
Ensembl peptide - ENSMUSP00000067897
Ensembl peptide - ENSMUSP00000106122
NCBI entrez gene - 140498     See in Manteia.
MGI - MGI:2153463
RefSeq - XM_011241023
RefSeq - NM_001289564
RefSeq - NM_001289566
RefSeq - NM_080468
RefSeq - XM_006504911
RefSeq - XM_011241021
RefSeq - XM_011241022
RefSeq Peptide - NP_536716
RefSeq Peptide - NP_001276493
RefSeq Peptide - NP_001276495
swissprot - E9Q0U9
swissprot - Q91ZZ5
swissprot - A0A0J9YV81
Ensembl - ENSMUSG00000053368
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rxfp2aENSDARG00000032820Danio rerio
 rxfp2bENSDARG00000019660Danio rerio
 RXFP2ENSG00000133105Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rxfp1 / Q6R6I7 / Relaxin receptor 1 / Q9HBX9* / relaxin/insulin like family peptide receptor 1*ENSMUSG0000003400951
Lgr5 / Q9Z1P4 / Leucine-rich repeat-containing G-protein coupled receptor 5 / O75473*ENSMUSG0000002014022
Lgr6 / Q3UVD5 / Leucine-rich repeat-containing G-protein coupled receptor 6 / Q9HBX8*ENSMUSG0000004279320
Lgr4 / A2ARI4 / Leucine-rich repeat-containing G-protein coupled receptor 4 / Q9BXB1*ENSMUSG0000005019920
Lhcgr / P30730 / Lutropin-choriogonadotropic hormone receptor / P22888* / AC073082.1* / luteinizing hormone/choriogonadotropin receptor*ENSMUSG0000002410719
Tshr / P47750 / thyroid stimulating hormone receptor / P16473*ENSMUSG0000002096318
Fshr / P35378 / Follicle-stimulating hormone receptor / P23945*ENSMUSG0000003293718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001611  Leucine-rich repeat
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR008112  Relaxin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016500 protein-hormone receptor activity IMP
 molecular_functionGO:0017046 peptide hormone binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Relaxin receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rxfp2tm1b(EUCOMM)Wtsi/Rxfp2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rxfp2tm1b(EUCOMM)Wtsi/Ieg

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Rsad1tm1.1(KOMP)Vlcg/Rsad1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Rsad1tm1.1(KOMP)Vlcg/Ucd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Rxfp2m1Lja/Rxfp2m1Lja
Genetic Background: C57BL/6J-Rxfp2m1Lja

Allelic Composition: Rxfp2tm1b(EUCOMM)Wtsi/Rxfp2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rxfp2tm1b(EUCOMM)Wtsi/Ieg

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Rsad1tm1.1(KOMP)Vlcg/Rsad1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Rsad1tm1.1(KOMP)Vlcg/Ucd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Rxfp2tm1b(EUCOMM)Wtsi/Rxfp2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rxfp2tm1b(EUCOMM)Wtsi/Ieg

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,Rxfp2tm1Aia/Rxfp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Rxfp2tm1Aia/Rxfp2tm1Aia
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Rxfp2m1Lja/Rxfp2m1Lja
Genetic Background: C57BL/6J-Rxfp2m1Lja

Allelic Composition: Rxfp2tm1a(EUCOMM)Wtsi/Rxfp2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Rxfp2tm1Aia/Rxfp2tm1Aia
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Rxfp2tm1Aia/Rxfp2tm1c(EUCOMM)Wtsi,Tg(Rarb-cre)1Bhr/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rxfp2tm1b(EUCOMM)Wtsi/Rxfp2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rxfp2tm1b(EUCOMM)Wtsi/Ieg

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Rxfp2tm1b(EUCOMM)Wtsi/Rxfp2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rxfp2tm1b(EUCOMM)Wtsi/Ieg

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Rxfp2tm1b(EUCOMM)Wtsi/Rxfp2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rxfp2tm1b(EUCOMM)Wtsi/Ieg

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Rxfp2tm1b(EUCOMM)Wtsi/Rxfp2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rxfp2tm1b(EUCOMM)Wtsi/Ieg

 MP:0003673 abnormal inguinal canal morphology "the passage in the lower abdominal wall through which the spermatic cord in the male or the round ligament in the female, nerves and vessels pass from the pelvic cavity to the scrotum or labia majora, respectively " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxfp2m1Lja/Rxfp2m1Lja
Genetic Background: C57BL/6J-Rxfp2m1Lja

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxfp2m1Lja/Rxfp2m1Lja
Genetic Background: C57BL/6J-Rxfp2m1Lja

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0005149 abnormal gubernaculum morphology "dysmorphology of the genitoinguinal ligaments that, in the male, connect the fetal testis to the developing scrotum, and, in the female, connect the ovaries to the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55881]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Rxfp2tm1b(EUCOMM)Wtsi/Rxfp2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rxfp2tm1b(EUCOMM)Wtsi/Ieg

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Rxfp2tm1b(EUCOMM)Wtsi/Rxfp2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rxfp2tm1b(EUCOMM)Wtsi/Ieg

 MP:0008259 abnormal optic disc morphology "any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxfp2tm1b(EUCOMM)Wtsi/Rxfp2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rxfp2tm1b(EUCOMM)Wtsi/Ieg

 MP:0009082 uterus cysts "presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,Rxfp2tm1Aia/Rxfp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0009213 absent male inguinal canal "absence of the passage in the lower abdominal wall through which the spermatic cord, nerves and vessels normally pass from the pelvic cavity to the scrotum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rxfp2tm1Aia/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0009251 enlarged endometrial glands "increase in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,Rxfp2tm1Aia/Rxfp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0009552 urinary bladder obstruction "any impediment or blockage of the musculomembranous elastic bag serving as a storage place for urine" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rxfp2tm1b(EUCOMM)Wtsi/Rxfp2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Rxfp2tm1b(EUCOMM)Wtsi/Ieg

 MP:0009671 abnormal uterus physiology "any anomaly in normal cyclical changes not due to anatomical defect" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,Rxfp2tm1Aia/Rxfp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0013401 increased endometrial gland number "greater than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:Anna]
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Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,Rxfp2tm1Aia/Rxfp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0013713 decreased nipple size "reduced size of the erectile projection at the apex of the mammary gland where the lactiferous ducts open" [ISBN:0-683-40008-8, MGI:Anna]
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Allelic Composition: Rxfp1tm1Aia/Rxfp1tm1Aia,Rxfp2tm1Aia/Rxfp2tm1Aia
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039097 Rln1 / relaxin 1 / RLN2* / P04808* / P04090* / relaxin 2*  / reaction / complex
 ENSMUSG00000079019 Insl3 / P51460* / insulin like 3*  / complex / reaction






 

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