ENSG00000133105


Homo sapiens

Features
Gene ID: ENSG00000133105
  
Biological name :RXFP2
  
Synonyms : Q8WXD0 / relaxin/insulin like family peptide receptor 2 / RXFP2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q13.1
Gene start: 31739542
Gene end: 31803388
  
Corresponding Affymetrix probe sets: 1553326_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000298386
Ensembl peptide - ENSP00000369670
NCBI entrez gene - 122042     See in Manteia.
OMIM - 606655
RefSeq - XM_017020389
RefSeq - NM_001166058
RefSeq - NM_130806
RefSeq Peptide - NP_570718
RefSeq Peptide - NP_001159530
swissprot - Q8WXD0
Ensembl - ENSG00000133105
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rxfp2aENSDARG00000032820Danio rerio
 rxfp2bENSDARG00000019660Danio rerio
 Rxfp2ENSMUSG00000053368Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RXFP1 / Q9HBX9 / relaxin/insulin like family peptide receptor 1ENSG0000017150952
LGR5 / O75473 / leucine rich repeat containing G protein-coupled receptor 5ENSG0000013929221
LGR6 / Q9HBX8 / leucine rich repeat containing G protein-coupled receptor 6ENSG0000013306720
LGR4 / Q9BXB1 / leucine rich repeat containing G protein-coupled receptor 4ENSG0000020521319
LHCGR / P22888 / luteinizing hormone/choriogonadotropin receptorENSG0000013803918
FSHR / P23945 / follicle stimulating hormone receptorENSG0000017082018
TSHR / P16473 / thyroid stimulating hormone receptorENSG0000016540917
AC073082.1ENSG000002799565


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001611  Leucine-rich repeat
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR008112  Relaxin receptor
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001556 oocyte maturation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016500 protein-hormone receptor activity IEA
 molecular_functionGO:0017046 peptide hormone binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Relaxin receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000104 Renal agenesis 
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 HP:0012741 Unilateral cryptorchidism "Absence of a testis from the scrotum on one side owing to failure of the testis or testes to descend through the inguinal canal to the testis." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000248099 INSL3 / P51460 / insulin like 3  / reaction / complex
 ENSG00000107014 RLN2 / P04090 / relaxin 2  / reaction / complex






 

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