ENSG00000205213


Homo sapiens

Features
Gene ID: ENSG00000205213
  
Biological name :LGR4
  
Synonyms : leucine rich repeat containing G protein-coupled receptor 4 / LGR4 / Q9BXB1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p14.1
Gene start: 27365961
Gene end: 27472775
  
Corresponding Affymetrix probe sets: 218326_s_at (Human Genome U133 Plus 2.0 Array)   222596_s_at (Human Genome U133 Plus 2.0 Array)   230674_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000368516
Ensembl peptide - ENSP00000431650
Ensembl peptide - ENSP00000374508
NCBI entrez gene - 55366     See in Manteia.
OMIM - 606666
RefSeq - NM_001346432
RefSeq - NM_018490
RefSeq Peptide - NP_001333361
RefSeq Peptide - NP_060960
swissprot - E9PK51
swissprot - Q9BXB1
Ensembl - ENSG00000205213
  
Related genetic diseases (OMIM): 615311 - {Bone mineral density, low, susceptibility to}, 615311
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lgr4ENSDARG00000060542Danio rerio
 LGR4ENSGALG00000040834Gallus gallus
 Lgr4ENSMUSG00000050199Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LGR6 / Q9HBX8 / leucine rich repeat containing G protein-coupled receptor 6ENSG0000013306746
LGR5 / O75473 / leucine rich repeat containing G protein-coupled receptor 5ENSG0000013929246
LHCGR / P22888 / luteinizing hormone/choriogonadotropin receptorENSG0000013803918
FSHR / P23945 / follicle stimulating hormone receptorENSG0000017082017
TSHR / P16473 / thyroid stimulating hormone receptorENSG0000016540917
RXFP1 / Q9HBX9 / relaxin/insulin like family peptide receptor 1ENSG0000017150915
RXFP2 / Q8WXD0 / relaxin/insulin like family peptide receptor 2ENSG0000013310515
AC073082.1ENSG000002799566


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR001611  Leucine-rich repeat
 IPR002131  Glycoprotein hormone receptor family
 IPR003591  Leucine-rich repeat, typical subtype
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation ISS
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030282 bone mineralization ISS
 biological_processGO:0030539 male genitalia development IEA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway ISS
 biological_processGO:0035239 tube morphogenesis IEA
 biological_processGO:0036335 intestinal stem cell homeostasis IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0046849 bone remodeling ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0050673 epithelial cell proliferation IEA
 biological_processGO:0050710 negative regulation of cytokine secretion ISS
 biological_processGO:0061290 canonical Wnt signaling pathway involved in metanephric kidney development IEA
 biological_processGO:0072202 cell differentiation involved in metanephros development IEA
 biological_processGO:0072224 metanephric glomerulus development IEA
 biological_processGO:0072282 metanephric nephron tubule morphogenesis IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 biological_processGO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IDA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016500 protein-hormone receptor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000169218 RSPO1 / Q2MKA7 / R-spondin 1  / reaction / complex
 ENSG00000146374 RSPO3 / Q9BXY4 / R-spondin 3  / complex / reaction
 ENSG00000108375 RNF43 / Q68DV7 / ring finger protein 43  / complex / reaction
 ENSG00000101282 RSPO4 / Q2I0M5 / R-spondin 4  / complex / reaction
 ENSG00000147655 RSPO2 / Q6UXX9 / R-spondin 2  / complex / reaction
 ENSG00000183579 ZNRF3 / Q9ULT6 / zinc and ring finger 3  / complex / reaction






 

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