ENSG00000183579


Homo sapiens

Features
Gene ID: ENSG00000183579
  
Biological name :ZNRF3
  
Synonyms : Q9ULT6 / zinc and ring finger 3 / ZNRF3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q12.1
Gene start: 28883592
Gene end: 29057487
  
Corresponding Affymetrix probe sets: 226360_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443824
Ensembl peptide - ENSP00000384456
Ensembl peptide - ENSP00000384553
NCBI entrez gene - 84133     See in Manteia.
OMIM - 612062
RefSeq - XM_017028990
RefSeq - NM_001206998
RefSeq - NM_032173
RefSeq - XM_011530435
RefSeq - XM_011530436
RefSeq - XM_011530437
RefSeq - XM_011530438
RefSeq Peptide - NP_001193927
RefSeq Peptide - NP_115549
swissprot - Q9ULT6
swissprot - A0A024R1J1
Ensembl - ENSG00000183579
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 znrf3ENSDARG00000062573Danio rerio
 ENSGALG00000005803Gallus gallus
 ENSGALG00000038861Gallus gallus
 Znrf3ENSMUSG00000041961Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RNF43 / Q68DV7 / ring finger protein 43ENSG0000010837525
Q9Y6U7 / RNF215 / ring finger protein 215ENSG0000009999910
Q9ULK6 / RNF150 / ring finger protein 150ENSG000001701538
ZNRF4 / Q8WWF5 / zinc and ring finger 4ENSG000001054288
Q9H6Y7 / RNF167 / ring finger protein 167ENSG000001085238
RNF13 / O43567 / ring finger protein 13ENSG000000829968
Q8TEB7 / RNF128 / ring finger protein 128, E3 ubiquitin protein ligaseENSG000001331357
Q86XS8 / RNF130 / ring finger protein 130ENSG000001132697
Q8NC42 / RNF149 / ring finger protein 149ENSG000001631627
Q8N7C7 / RNF148 / ring finger protein 148ENSG000002356315
Q8WVZ7 / RNF133 / ring finger protein 133ENSG000001880505


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IEA
 biological_processGO:0038018 Wnt receptor catabolic process TAS
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IEA
 biological_processGO:0072089 stem cell proliferation ISS
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 biological_processGO:2000051 negative regulation of non-canonical Wnt signaling pathway IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005109 frizzled binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity TAS


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101282 RSPO4 / Q2I0M5 / R-spondin 4  / reaction / complex
 ENSG00000139292 LGR5 / O75473 / leucine rich repeat containing G protein-coupled receptor 5  / complex / reaction
 ENSG00000133067 LGR6 / Q9HBX8 / leucine rich repeat containing G protein-coupled receptor 6  / complex / reaction
 ENSG00000147655 RSPO2 / Q6UXX9 / R-spondin 2  / complex / reaction
 ENSG00000146374 RSPO3 / Q9BXY4 / R-spondin 3  / complex / reaction
 ENSG00000169218 RSPO1 / Q2MKA7 / R-spondin 1  / reaction / complex
 ENSG00000205213 LGR4 / Q9BXB1 / leucine rich repeat containing G protein-coupled receptor 4  / complex / reaction
 ENSG00000174804 FZD4 / Q9ULV1 / frizzled class receptor 4  / complex / reaction
 ENSG00000070018 LRP6 / O75581 / LDL receptor related protein 6  / complex / reaction
 ENSG00000154342 WNT3A / P56704 / Wnt family member 3A  / reaction / complex






 

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