ENSG00000133135


Homo sapiens

Features
Gene ID: ENSG00000133135
  
Biological name :RNF128
  
Synonyms : Q8TEB7 / ring finger protein 128, E3 ubiquitin protein ligase / RNF128
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q22.3
Gene start: 106693794
Gene end: 106796993
  
Corresponding Affymetrix probe sets: 219263_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000255499
Ensembl peptide - ENSP00000316127
Ensembl peptide - ENSP00000412610
NCBI entrez gene - 79589     See in Manteia.
OMIM - 300439
RefSeq - NM_024539
RefSeq - NM_194463
RefSeq Peptide - NP_078815
RefSeq Peptide - NP_919445
swissprot - Q5JSK4
swissprot - Q8TEB7
Ensembl - ENSG00000133135
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf128aENSDARG00000016867Danio rerio
 si:dkeyp-86f7.4ENSDARG00000029890Danio rerio
 ENSGALG00000041977Gallus gallus
 Q9D304ENSMUSG00000031438Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8WVZ7 / RNF133 / ring finger protein 133ENSG0000018805043
Q9ULK6 / RNF150 / ring finger protein 150ENSG0000017015336
Q8N7C7 / RNF148 / ring finger protein 148ENSG0000023563136
Q8NC42 / RNF149 / ring finger protein 149ENSG0000016316234
Q86XS8 / RNF130 / ring finger protein 130ENSG0000011326932
RNF43 / Q68DV7 / ring finger protein 43ENSG0000010837518
RNF13 / O43567 / ring finger protein 13ENSG0000008299617
Q9H6Y7 / RNF167 / ring finger protein 167ENSG0000010852316
ZNRF3 / Q9ULT6 / zinc and ring finger 3ENSG0000018357916
ZNRF4 / Q8WWF5 / zinc and ring finger 4ENSG0000010542814
Q9Y6U7 / RNF215 / ring finger protein 215ENSG0000009999913


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR003137  PA domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process NAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0042036 negative regulation of cytokine biosynthetic process IEA
 biological_processGO:0061462 protein localization to lysosome IC
 biological_processGO:1904352 positive regulation of protein catabolic process in the vacuole IC
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138592 USP8 / P40818 / ubiquitin specific peptidase 8  / complex
 ENSG00000167770 OTUB1 / Q96FW1 / OTU deubiquitinase, ubiquitin aldehyde binding 1  / complex






 

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