ENSMUSG00000031438


Mus musculus

Features
Gene ID: ENSMUSG00000031438
  
Biological name :Rnf128
  
Synonyms : E3 ubiquitin-protein ligase RNF128 / Q9D304 / Rnf128
  
Possible biological names infered from orthology : Q8TEB7 / ring finger protein 128, E3 ubiquitin protein ligase
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F1
Gene start: 139563316
Gene end: 139673145
  
Corresponding Affymetrix probe sets: 10602009 (MoGene1.0st)   1418318_at (Mouse Genome 430 2.0 Array)   1449036_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108649
Ensembl peptide - ENSMUSP00000108650
NCBI entrez gene - 66889     See in Manteia.
MGI - MGI:1914139
RefSeq - NM_001254761
RefSeq - NM_023270
RefSeq Peptide - NP_001241690
RefSeq Peptide - NP_075759
swissprot - Q9D304
swissprot - A2AGL8
Ensembl - ENSMUSG00000031438
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf128aENSDARG00000016867Danio rerio
 si:dkeyp-86f7.4ENSDARG00000029890Danio rerio
 ENSGALG00000041977Gallus gallus
 Q8TEB7ENSG00000133135Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
G3X9R7 / Rnf148 / RING finger protein 148 / Q8N7C7*ENSMUSG0000007817939
Q14B02 / Rnf133 / E3 ubiquitin-protein ligase RNF133 / Q8WVZ7* / ring finger protein 133*ENSMUSG0000005195638
Q5DTZ6 / Rnf150 / RING finger protein 150 / Q9ULK6*ENSMUSG0000004774736
Q8VEM1 / Rnf130 / ring finger protein 130 / Q86XS8*ENSMUSG0000002037634
Q3U2C5 / Rnf149 / E3 ubiquitin-protein ligase RNF149 / Q8NC42* / ring finger protein 149*ENSMUSG0000004823432
Rnf13 / O54965 / ring finger protein 13 / O43567*ENSMUSG0000003650318
Rnf43 / Q5NCP0 / E3 ubiquitin-protein ligase RNF43 / Q68DV7* / ring finger protein 43*ENSMUSG0000003417717
Q91XF4 / Rnf167 / E3 ubiquitin-protein ligase RNF167 / Q9H6Y7* / ring finger protein 167*ENSMUSG0000004074616
Znrf3 / Q5SSZ7 / zinc and ring finger 3 / Q9ULT6*ENSMUSG0000004196116
Q5SPX3 / Rnf215 / RING finger protein 215 / Q9Y6U7*ENSMUSG0000000358113
Znrf4 / Q9DAH2 / zinc and ring finger 4 / Q8WWF5*ENSMUSG0000004452611


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR003137  PA domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0042036 negative regulation of cytokine biosynthetic process IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISO


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: C57BL/6

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp3tm2Ayr/Foxp3+,Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxp3tm2Ayr/Foxp3+,Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0005000 immune tolerance "the failure to respond to an antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Clcn7tm4.1Tjj/Clcn7+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rnf128tm1.1Flv/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Rnf128tm1.1Flv/Y,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trim21tm1Mwah/Trim21+
Genetic Background: C57BL/6-Trim21tm1Mwah

Allelic Composition: Rnf128tm1.1Flv/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trim21tm1Mwah/Trim21+
Genetic Background: C57BL/6-Trim21tm1Mwah

Allelic Composition: Rnf128tm1.1Flv/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0008466 enlarged mesenteric lymph nodes "increased size of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Trim21tm1Mwah/Trim21+
Genetic Background: C57BL/6-Trim21tm1Mwah

Allelic Composition: Rnf128tm1.1Flv/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: C57BL/6

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0008599 increased circulating interleukin-2 level "increase in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Trim21tm1Mwah/Trim21+
Genetic Background: C57BL/6-Trim21tm1Mwah

Allelic Composition: Rnf128tm1.1Flv/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Rnf128tm1.1Flv/Rnf128tm1.1Flv,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf128tm1.1Flv/Y,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: C57BL/6

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: C57BL/6

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0008749 abnormal peripheral T cell anergy "any anomaly of the processes of T cell anergy that occur outside the thymus" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim21tm1Mwah/Trim21+
Genetic Background: C57BL/6-Trim21tm1Mwah

Allelic Composition: Rnf128tm1.1Flv/Y
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Rnf128tm1.1Flv/Rnf128tm1.1Flv,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

Allelic Composition: Rnf128tm1.1Flv/Y,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL/6

 MP:0009057 increased interleukin-21 secretion "increase in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Rnf128tm1Cdon/Rnf128tm1Cdon
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024767 Otub1 / Q7TQI3 / Ubiquitin thioesterase OTUB1 / Q96FW1* / OTU deubiquitinase, ubiquitin aldehyde binding 1*  / complex
 ENSMUSG00000027363 Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*  / complex






 

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