ENSMUSG00000041961


Mus musculus

Features
Gene ID: ENSMUSG00000041961
  
Biological name :Znrf3
  
Synonyms : Q5SSZ7 / zinc and ring finger 3 / Znrf3
  
Possible biological names infered from orthology : Q9ULT6
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 5276324
Gene end: 5444847
  
Corresponding Affymetrix probe sets: 10383982 (MoGene1.0st)   1435608_at (Mouse Genome 430 2.0 Array)   1437646_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105493
Ensembl peptide - ENSMUSP00000122475
Ensembl peptide - ENSMUSP00000134698
NCBI entrez gene - 407821     See in Manteia.
MGI - MGI:3039616
RefSeq - NM_001080924
RefSeq - NM_001290501
RefSeq Peptide - NP_001074393
RefSeq Peptide - NP_001277430
swissprot - F7D553
swissprot - Q5SSZ7
Ensembl - ENSMUSG00000041961
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 znrf3ENSDARG00000062573Danio rerio
 ENSGALG00000005803Gallus gallus
 ENSGALG00000038861Gallus gallus
 ZNRF3ENSG00000183579Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rnf43 / Q5NCP0 / E3 ubiquitin-protein ligase RNF43 / Q68DV7* / ring finger protein 43*ENSMUSG0000003417724
Q5SPX3 / Rnf215 / RING finger protein 215 / Q9Y6U7*ENSMUSG0000000358110
Rnf13 / O54965 / ring finger protein 13 / O43567*ENSMUSG000000365039
Q8VEM1 / Rnf130 / ring finger protein 130 / Q86XS8*ENSMUSG000000203768
Q5DTZ6 / Rnf150 / RING finger protein 150 / Q9ULK6*ENSMUSG000000477478
Q9D304 / Rnf128 / E3 ubiquitin-protein ligase RNF128 / Q8TEB7* / ring finger protein 128, E3 ubiquitin protein ligase*ENSMUSG000000314388
Q91XF4 / Rnf167 / E3 ubiquitin-protein ligase RNF167 / Q9H6Y7* / ring finger protein 167*ENSMUSG000000407468
Q3U2C5 / Rnf149 / E3 ubiquitin-protein ligase RNF149 / Q8NC42* / ring finger protein 149*ENSMUSG000000482347
Znrf4 / Q9DAH2 / zinc and ring finger 4 / Q8WWF5*ENSMUSG000000445266
G3X9R7 / Rnf148 / RING finger protein 148 / Q8N7C7*ENSMUSG000000781795
Q14B02 / Rnf133 / E3 ubiquitin-protein ligase RNF133 / Q8WVZ7* / ring finger protein 133*ENSMUSG000000519565


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IMP
 biological_processGO:0038018 Wnt receptor catabolic process ISO
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway IMP
 biological_processGO:0072089 stem cell proliferation IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISS
 biological_processGO:2000051 negative regulation of non-canonical Wnt signaling pathway ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005109 frizzled binding ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002404 intestinal adenoma "benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

Allelic Composition: Rnf43tm1Cle/Rnf43tm1Cle,Znrf3tm1Cle/Znrf3tm1Cle,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003078 aphakia "absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0012168 abnormal optic placode morphology "any structural anomaly of the paired thickenings of surface ectoderm that become invaginated to form the embryonic lens vesicles" [MGI:anna]
Show

Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0013485 increased Paneth cell number "greater than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
Show

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000009900 Wnt3a / P27467 / wingless-type MMTV integration site family, member 3A / P56704* / Wnt family member 3A*  / reaction / complex
 ENSMUSG00000020140 Lgr5 / Q9Z1P4 / Leucine-rich repeat-containing G-protein coupled receptor 5 / O75473*  / complex / reaction
 ENSMUSG00000028871 Rspo1 / R-spondin 1 / Q2MKA7*  / complex / reaction
 ENSMUSG00000030201 Lrp6 / LDL receptor related protein 6 / O75581*  / complex / reaction
 ENSMUSG00000032852 Rspo4 / Q8BJ73 / R-spondin-4 / Q2I0M5*  / complex / reaction
 ENSMUSG00000042793 Lgr6 / Q3UVD5 / Leucine-rich repeat-containing G-protein coupled receptor 6 / Q9HBX8*  / complex / reaction
 ENSMUSG00000050199 Lgr4 / A2ARI4 / Leucine-rich repeat-containing G-protein coupled receptor 4 / Q9BXB1*  / complex / reaction
 ENSMUSG00000049791 Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*  / reaction / complex
 ENSMUSG00000051920 Rspo2 / Q8BFU0 / Mus musculus R-spondin 2 (Rspo2), transcript variant 1, mRNA. / Q6UXX9* / R-spondin 2*  / complex / reaction
 ENSMUSG00000019880 Rspo3 / Q2TJ95 / R-spondin-3 / Q9BXY4*  / complex / reaction






 

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